Enzyme induction in the cytochrome P-450 system

Pharmacology and Therapeutics

Volumn 45, Issue 2, 1990, Pages 241-298

  Okey, Allan B ^a,b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLCHOLANTHRENE; ALCOHOL; CYTOCHROME P450; CYTOCHROME P450 ISOENZYME; PHENOBARBITAL;

BIRD; CELL CULTURE; ENZYME INDUCTION; FISH; FUNGUS; HUMAN; LIVER; METHODOLOGY; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; REVIEW; TISSUE CULTURE;

ANIMAL; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; HUMAN; SUPPORT, NON-U.S. GOV'T;

EID: 0025055648     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/0163-7258(90)90030-6     Document Type: Article

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224. Further studies on the effect of petroleum hydrocarbons on mixed-function oxidases in marine organisms
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242. Species differences in responsiveness to 1, 4-Bis[2-(3, 5-dichloropyridyloxy)]benzene, a potent phenobarbital-like inducer of microsomal monooxygenase activity
243. The murine Ah locus: A new allele and mapping to chromosome 12
244. Stability of human liver foreign compound metabolizing activity to low temperature storage
245. 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD): translocation with Ah receptor into nuclei of hepatoma cells in culture
246. Characteristics of benzo[a]pyrene metabolism by kidney, liver, and lung microsomal fraction from rodents and humans
247. Decreased induction of aryl hydroxylase activity in hyperproliferative hairlines mouse epidermis
248. Human cytochrome P-450 4 mRNA and gene: Part of a multigene family that contains Alu sequence in its mRNA
249. Drug-induced porphyrin biosynthesis. II. Simple procedure for screening drugs for porphyria-inducing activity
250. Certain photooxidized derivatives of tryptophan bind with very high affinity to the Ah receptor and are likely to be endogenous signal substances
251. Peroxisome proliferators and cancer: mechanismis and implications
252. Drug tolerance
253. Drug-induced changes in the liver endoplasmic reticulum: association with drug-metabolizing enzymes
254. Factors affecting drug biotransformation
255. Cytochrome P-450-catalyzed formation of delta-4-VPA, a toxic metabolite of valproic acid
256. Seasonal variation of aryl hydrocarbon hydroxylase inducibility in human lymphocytes in culture
257. Induction of both cytochromes P-450 and P-448 by 2, 3′, 4, 4t́, 5-pentabromobiphenyl, a component of Firemaster
258. Quantitative structure-activity relationships: analysis of interactions of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin and 2-substituted analogues with rat, mouse, guinea pig, and hamster cytosolic receptor
259. Binding characteristics of 4-S proteins from rat and mouse liver: high affinity of ellipticines
260. Acylureas A new class of barbiturate-like bacterial cytochrome P-450 inducers
261. Separation and characterization of highly purified forms of liver microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital, and 3-methylcholanthrene
262. Characterization of a major form of rat hepatic microsomal cytochrome P-450 induced by isoniazid
263. Ethanol-inducible rat and human liver cytochrome P-450: characterization and role as high affinity N-nitrosodimethylamine demethylases
264. Comparative toxicology and mechanism of action of polychlorinated dibenzo-p-dioxins and dibenzofurans
265. The aryl hydrocarbon (Ah) receptor
266. PCBs: Structure-function relationships and mechanism of action
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286. Effect of culture age on drug metabolizing enzymes and their induction in primary cultures of rat hepatocytes
287. Multiple forms of hepatic cytochrome P-450. Purification, characterization and comparison of a novel clofibrate-induced isozyme with other major forms of cytochrome P-450
288. Use of monoclonal antibody probes against rat hepatic cytochromes P-450c and P-450d to detect immunochemically related isozymes in liver microsomes from different species
289. Polyclonal and monoclonal antibodies as pobes of rat hepatic cytochrome P-450 isozymes
290. The identity and nuclear uptake of a cytosolic binding protein for 3-methylcholanthrene
291. The isolation and characterization of specific 3-methylcholanthrene-binding proteins from rat liver cytosol
292. Rapid vertical tube rotor gradient assay for binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to the Ah receptor
293. High-affinity nitrosamine dealkylase system in rat liver microsomes and in induction by fasting
294. Induction of high-affinity nitrosamine demethylase in rat liver microsomes by acetone and isopranol
295. 1-450 induction by use of a cloned DNA sequence
296. 1-450 mRNA
297. 3-450 genes to mouse chromosome 9
298. Differential regulation of human cytochrome P-450 genes
299. 3-450 genes
300. An example of P-450 catalytic activities not correlated with corresponding P-450 mRNA concentrations
301. The rat P450IIE1 gene: Complete intron and exon sequence, chromosome mapping, and correlation of developmental expression with specific 5′ cytosine demethylation
302. Aryl hydrocarbon hydroxylase tissue-specific activities: evidence for baseline levels in mammalian tissues
303. Single-step phototoxic selection procedure for isolating cells that possess aryl hydrocarbon hydroxylase
304. Hepatic cytochrome P-450 isozymes and aryl hydrocarbon hydroxylase in English sole (Parophrys vetulus)
305. The antipyrine test in clinical pharmacology: conceptions and misconceptions
306. Effects of somatostasin and testosterone on the hepatic monooxygenase system in castrated male rats
307. Characterization of the induction response of the hepatic microsomal monooxygenase (MO) system of fishes
308. Inducers of cytochrome P-450d: Influence on microsomal catalytic activities and differential regulation by enzyme stabilization
309. 1-450 gene expression in newly established human lymphoblastoid lines
310. Purification and characterization of six cytochrome P-450 isozymes from human liver microsomes
311. Induction of aryl hydrocarbon hydroxylase by 3-methylcholanthrene in liver, lung and kidney of gonadectomized and sham-operated Wistar rats
312. Differential effects of diabetes on microsomal metabolism of various substrates. Comparison of streptozotocin and spontaneously diabetic Wistar rats
313. Chemoprevention of cancer
314. Effects of phenothiazine on protective systems against polycyclic hydrocarbons
315. Induction of increased benzpyrene hydroxylase activity by flavones and related compounds
316. Regulation of the biosynthesis of cytochromes P-450 involved in steroid hormone synthesis
317. Regulation of synthesis and activity of cytochrome P-450 enzymes in physiological pathways
318. Mutli-factorial regulation of steroid hydroxylase gene expression
319. Phenobarbital induces cytochrome P-450- and cytochrome P-450-dependent monooxygenase in rat hepatoma cells
320. Cigarette smoking: Stimulatory effect on metabolism of 3,4-benzpyrene by enzymes in human placenta
321. Cigarette smoke: stimulatory effect on metabolism of 3,4-benzpyrene by enzymes in rat lung
322. The regulation of cytochrome P-450 gene expression
323. The regulation of gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin
324. Aryl hydrocarbon (benzo[1]pyrene) hydroxylase is stimulated in human lymphocytes by mitogens and benz[a]pyrene
325. Cytochrome P-450s: polymorphic multigene families involved in carcinogen activation
326. Dietary exposure to used PCBs strongly inducedk placental mixed-function oxidase activity
327. Correlation of placental microsomal activities with protein detected by antibodies to rabbit cytochrome P-450 isozyme 6 in preparations from humans exposed to polychlorinated biphenyls, quarterphenyls, and dibenzofurans
328. Nondetectable concentrations of human placental Ah receptors are associated with potent induction of microsomal benzo[a]pyrene hydroxylase in individuals exposed to polychlorinated biphenyls, quarterphenyls and dibenzofurans
329. Effects of hypophysectomy and growth hormone treatment on sex-specific forms of cytochrome P-450 in relation to drug and steroid metabolisms in rat liver microsomes
330. Suppression of levels of phenobarbital-inducible rat liver cytochrome P-450 by pituitary hormone
331. Induction of specific cytochrome P-450 isozymes by methylenedioxphenyl compounds and antagonism by 30-methylcholanthrene
332. Suppression of the constitutive, male-specific rat hepatic cytochrome P-450 2c and its mRNA by 3,4,5,3′,4′,5′-hexachlorobiphenyl and 3-methylcholanthrene
333. Strain-differences and inducibility of microsomal oxidative enzymes in Drosophila melanogaster flies
334. Identification and characterization of a high-affinity saturable binding protein for the carcinogen benzo[a]pyrene