In vitro studies on the action of CS-045, a new antidiabetic agent

Metabolism

Volumn 39, Issue 10, 1990, Pages 1056-1062

  Ciaraldi, Theodore P ^a,b   Gilmore, Allison ^a,b   Olefsky, Jerrold M ^a,b   Goldberg, Michelle ^a,b   Heidenreich, Kim A ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOGEN SYNTHASE; INSULIN; LACTIC ACID; RADIOISOTOPE; TROGLITAZONE;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; GLUCOSE TRANSPORT; HEPATOMA CELL; HUMAN; HUMAN CELL; MUSCLE CELL; PRIORITY JOURNAL;

BIOLOGICAL TRANSPORT; CELL SURVIVAL; CELLS, CULTURED; CHROMANS; GLUCONEOGENESIS; GLUCOSE; GLYCOGEN SYNTHASE; HUMAN; HYPOGLYCEMIC AGENTS; INSULIN; LIVER; MUSCLES; SUPPORT, NON-U.S. GOV'T; THIAZOLES;

EID: 0025054203     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/0026-0495(90)90166-A     Document Type: Article

References (50)

1. Mechanisms of insulin resistance in non-insulin-dependent (type II) diabetes
2. Pathogenesis of insulin resistance and hyperglycemia in non-insulin dependent diabetes mellitus
3. The acute and chronic effects of sulfonylurea therapy in type II diabetic subjects
4. Effect of chlorpropamide on serum glucose and immunoreactive insulin concentrations in patients with maturityonset diabetes mellitus
5. Selective potentiation of insulin-mediated glucose disposal in normal dogs by the sulfonylurea Glipizide
6. Prolonged sulfonylurea administration decreases insulin resistance and increases insulin secretion in non-insulin dependent diabetes mellitus
7. Sulfonylureas improve insulin binding and insulin action in non-insulin dependent diabetes mellitus
8. The impact of sulfonylurea treatment upon the mechanisms responsible for the insulin resistance in type II diabetes
9. Gliclazide therapy is associated with potentiation of postbinding insulin action in obese non-insulin-dependent diabetic subjects
10. Reversal of insulin resistance in adipose tissue of non-insulin-dependent diabetics by treatment with diet and sulphonylurea
11. Dual actions of sulfonylurea and glyburide: Receptor and postreceptor effects
12. Effect of biguanides and sulfonylureas on insulin receptors in cultured cells
13. Modulation by a sulfonylurea of insulin-dependent glycogenesis, but not of insulin binding, in cultured rat hepatocytes
14. Effect of glyburide on glycogen metabolism in cultured rat hepatocytes
15. Cyclic AMP phosphodiesterase in diabetes. Effect of glyburide
16. Sulphonylureas increase the number of insulin receptors
17. Potentiation of insulin action by a sulfonylurea in primary cultures of hepatocytes from normal and diabetic rats
18. Insulin like effects and insulin-enhancing of the sulfonylurea glyburide on rat adipose glycogen synthase
19. Direct in vitro effect of a sulfonylurea to increase human fibroblast insulin receptors
20. Characterization of a new oral anti-diabetic agent CS-045: Studies in KK and ob/ob mice and Zucker fatty rats
21. Insulin receptors and bioresponses in a human liver cell line (Hep G-2)
22. Hormonal regulation of low-density lipoprotein (LDL) receptor activity in human hepatoma Hep G2 cells. Insulin increases LDL receptor activity and diminishes its suppression by exogenous LDL
23. Insulin and insulin-like growth factor I regulate the same biological functions in Hep G2 cells via their own specific receptors
24. Epidermal growth factor counteracts the glycogenic effect of insulin in parenchymal hepatocyte cultures
25. Effect of monoclonal antibodies on human insulin receptor autophosphorylation, negative cooperativeity, and down-regulation
26. Biosynthesis and processing of the human insulin receptor
27. Insulin-like growth factor I binding in hepatocytes from human liver, human hepatoma, and normal, regenerating and fetal rat liver
28. Characterization of a unique muscle cell line
29. Multiple controls for the synthesis of muscle-specific proteins in BC3H-1 cells
30. The development of insulin receptors and responses in the differentiating non fusing muscle cell line BC3H-1
31. Insulin-stimulated microtubule associated protein kinase is detectable by analytical gel chromatography as a 35-kDa protein in myocytes, adipocytes, and hepatocytes
32. Muscle cell differentiation is associated with increased insulin receptor biosynthesis and messenger RNA levels
33. Insulin increases membrane and cytosalic protein kinase C activity in BC3H-1 myocytes
34. Regulation of glycogen metabolism in primary cultures of rat hepatocytes. Restoration of acute effects of insulin and glucose in cells from diabetic rats
35. 14C-glucose
36. Induction in primary culture of “gluconeogenic” and “glycolytic” hepatocytes resembling perportal and perivenous cells
37. Regulation of glycogen synthesis in the liver
38. Phosphorylation-dephosphorylation of enzymes
39. An on-off mechanism for liver glycogen synthase activity
40. Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM
41. Effect of ciglitazone on glucose uptake and insulin sensitivity in skeletal muscle of the obese (ob/ob) mouse: Distinct insulin and glucocorticoid effects
42. Inhibition of hepatic gluconeogenesis by metformin
43. The insulin receptor: Basic characteristics and its role in insulin resistant states
44. Longterm regulation of adipocyte glucose transport capacity by circulating insulin in rats
45. Insulin induces progressive insulin resistance in cultured rat adipocytes
46. Long-term regulation of hexose transport by insulin in cultured mouse (3T3) adipocytes
47. In vitro autoregulation of glucose utilization in rat soleus muscle
48. 3H]2-deoxyglucose uptake and protein kinase C activity in BC3H-1 myocytes
49. Sulfonylurea effects in cultured skeletal muscle cells: Augmentation of insulin and insulin-like growth factor I and II actions
50. Sulfonylurea potentiates insulin-induced recruitment of glucose transport carrier in rat adipocytes