Flumazenil Provocation of Panic Attacks: Evidence for Altered Benzodiazepine Receptor Sensitivity in Panic Disorder

Archives of General Psychiatry

Volumn 47, Issue 10, 1990, Pages 917-925

  Nutt, David J ^a   Glue, Paul ^a   Lawson, Chris ^a   Wilson, Sue ^a  

^a Reckitt & Colman   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE RECEPTOR; FLUMAZENIL;

ADULT; ANXIETY; ARTICLE; CLINICAL ARTICLE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; PANIC; PRIORITY JOURNAL; PSYCHOLOGICAL ASPECT;

ADOLESCENT; ADULT; ANXIETY DISORDERS; BLOOD PRESSURE; DOUBLE-BLIND METHOD; FEMALE; FLUMAZENIL; HEART RATE; HUMAN; INFUSIONS, INTRAVENOUS; LIGANDS; MALE; PANIC; PLACEBOS; RECEPTORS, GABA-A;

EID: 0025049828     PISSN: 0003990X     EISSN: 15383636     Source Type: Journal    
DOI: 10.1001/archpsyc.1990.01810220033004     Document Type: Article

References (65)

1. Kahn RJ, McNair DM, Lipman RS, Covi L, Rickels K, Downing R, Fisher S, Frankenthaler LM. Imipramine and chlordiazepoxide in depressive and anxiety disorders. Arch Gen Psychiatry. 1986;43:79-85.
2. Rickels K, Weisman K, Norstad N, Singer M, Stoltz D, Brown A, Danton J. Buspirone and diazepam in the treatment of anxiety: a controlled study. J Clin Psychiatry. 1982;43:81-86.
3. Hallstrom C, Treasaden I, Edwards JG, Lader M. Diazepam, propranolol and their combination in the management of chronic anxiety. Br J Psychiatry. 1981;139:417-421.
4. Rickels K, Schweizer E, Csanalosi I, Case G, Chung H. Long-term treatment of anxiety and risk of withdrawal. Arch Gen Psychiatry. 1988;45:444-450.
5. Schweizer E, Fox I, Case G, Rickels K. Lorazepam vs alprazolam in the treatment of panic disorder. Psychopharmacol Bull. 1988;24:224-227.
6. Rickels K, Schweizer E. Benzodiazepines for the treatment of panic attacks: a new look. Psychopharmacol Bull. 1986;22:93-99.
7. Sheehan DV. Current perspectives in the treatment of panic and phobic disorders. Drug Therapy. September 1982:179-193.
8. Sheehan DV. Benzodiazepines in panic disorder and agoraphobia. J Affective Disord. 1987;13:169-181.
9. Ballenger JC, Burrows GD, DuPont RL, Lesser IM, Noyes R, Pecknold JC, Rifkin A, Swinson RP. Alprazolam in panic disorder and agoraphobia: results from a multicenter trial, I: efficacy in short-term treatment. Arch Gen Psychiatry. 1988;45:413-422.
10. Squires RF, Braestrup C. Benzodiazepine receptors in rat brain. Nature. 1977;266:732-734.
11. Mohler H, Okada R. Benzodiazepine receptor: demonstration in the central nervous system. Science. 1977;198:849-851.
12. Petersen EN. Benzodiazepine receptor pharmacology: new vistas. Drugs of the Future. 1987;12:1043-1053.
13. Haefely W. Tranquillizers. In: Grahame-Smith DG, Cowen PJ, eds. Psychopharmacology II. Amsterdam, the Netherlands: Elsevier Science Publishers; 1985:92-182.
14. Haefely W, Kyburz E, Gerecke M, Mohler H. Recent advances in the molecular pharmacology of benzodiazepine receptors and in the structure activity relationships of their agonists and antagonists. Adv Drug Res. 1985;14:165-322.
15. Braestrup C, Nielsen M, Honore T, Jensen LH, Petersen EN. Benzodiazepine receptor ligands with positive and negative efficacy. Neuropharmacology. 1983;22:1451-1457.
16. Nutt DJ. Benzodiazepine receptor ligands. Neurotransmissions. 1988;4:1-6.
17. Dorow R, Horowski R, Paschelke G, Amin M, Braestrup C. Severe anxiety induced by FG 7142, a β-carboline ligand for benzodiazepine receptors. Lancet. 1983;2:98-99.
18. Gentil V, Tavares S, Gorenstein C, Bello C, Mathias L, Gronich G, Singer J. Acute reversal of flunitrazepam effects by Ro 15-1788 and Ro 15-3505: inverse agonism, tolerance and rebound. Psychopharmacology (Berlin). 1990;100:54-59.
19. Hunkeler W, Mohler H, Pieri L, Pole P, Bonetti EP, Cumin R, Schaffner R, Haefely W. Selective antagonists of benzodiazepines. Nature. 1981;290:515-516.
20. Haefely W, Hunkeler W. The story of flumazenil. Eur J Anaesthesiol. 1988;2:3-14.
21. Nutt DJ, Cowen PC, Little HJ. Unusual interactions of benzodiazepine receptor antagonists. Nature. 1982;295:436-438.
22. Barbaccia MC, Costa E, Ferrero P, Guidotti A, Roy A, Sunderland T, Pickar D, Paul SM, Goodwin FK. Diazepam-binding inhibitor. Arch Gen Psychiatry. 1986;43:1143-1147.
23. Ferrero P, Santi M, Conti-Tronconi B, Costa E, Guidotti A. Study of an octadecaneuropeptide derived from DBI: biological activity and presence in rat brain. Proc Natl Acad Sci USA. 1986;83:827-831.
24. Clow A, Glover V, Sandler M, Tiller J. Increased urinary tribulin output in generalised anxiety disorder. Psychopharmacology (Berlin). 1988;95:378-380.
25. Davidson J, Glover V, Clow A, Kudler H, Meador K, Sandler M. Tribulin in post-traumatic stress disorder. Psychol Med. 1988;4:833-836.
26. De Blas AL. Diazepam and N-desmethyldiazepam in plant food and in brain. Trends Neurosci. 1988;11:489-490.
27. Sangameswaran L, Fales HM, Friedrich P, De Blas AL. Purification of a benzodiazepine from bovine brain and detection of benzodiazepine-like immunoreactivity in human brain. Proc Natl Acad Sci USA. 1986;83:9236-9240.
28. Sangameswaran L, De Blas AL. Demonstration of benzodiazepine-like molecules in the mammalian brain with a monoclonal antibody to benzodiazepines. Proc Natl Acad Sci USA. 1985;82:5560-5564.
29. Nutt DJ. Benzodiazepine dependence in the clinic: reason for anxiety. Trends Pharmacol Sci. 1986;7:457-460.
30. Little HJ, Nutt DJ, Taylor SC. Bidirectional effects of chronic treatment with agonists and inverse agonists at the benzodiazepine receptor. Brain Res Bull. 1987;19:371-378.
31. Little HJ, Gale R, Sellars N, Nutt DJ, Taylor SC. Chronic benzodiazepine treatment increases the effects of the inverse agonist FG 7142. Neuropharmacology. 1988;27:383-389.
32. Little HJ, Nutt DJ, Taylor SC. Kindling and withdrawal changes at the benzodiazepine receptor. J Psychopharmacol. 1987;1:35-46.
33. Pevnik JS, Jasinski DR, Haertzen CA. Abrupt withdrawal from therapeutically administered diazepam. Arch Gen Psychiatry. 1978;35:995-998.
34. Winokur A, Rickels K, Greenblatt DJ, Snyder PJ, Schatz NJ. Withdrawal reaction from long-term low-dosage administration of diazepam. Arch Gen Psychiatry. 1980;37:101-105.
35. Petursson H, Lader MH. Withdrawal from long-term benzodiazepine treatment. BMJ. 1981;283:643-645.
36. Tyrer P, Owen R, Dawling S. Gradual withdrawal of diazepam after long-term therapy. Lancet. 1983;1:1402-1406.
37. Clark DM, Hemsley DR. The effects of hyperventilation: individual variability and its relation to personality. J Behav Ther Exp Psychiatry. 1982;13:41-47.
38. George DT, Zerby A, Noble S, Nutt DJ. Panic attacks and alcohol withdrawal: can subjects differentiate the symptoms? Biol Psychiatry. 1988;24:240-243.
39. Persson A, Pauli S, Halldin C, Ston-Elander S, Farde L, Sjogren I, Sedvall G. Saturation analysis of specific 11C Ro 15-1788 binding in the human neocortex using positron emission tomography. Hum Psychopharmacol. 1989;4:21-31.
40. Roncari G, Ziegler WH, Guentert TW. Pharmacokinetics of the new benzodiazepine antagonist Ro 15-1788 in man following intravenous and oral administration. Br J Clin Pharmacol. 1986;22:421-428.
41. MargrafJ, Taylor CB, Ehlers A, Roth WT, Agras WS. Panic attacks in the natural environment. J Nerv Ment Dis. 1987;175:558-565.
42. Woods SW, Charney DS, McPherson CA, Gradman AH, Heninger GR. Situational panic attacks. Arch Gen Psychiatry. 1987;44:365-375.
43. Taylor CB, King R, Ehlers A, Margraf J, Clark D, Hayward C, Roth WT, Agras S. Treadmill exercise test and ambulatory measures in panic attacks. Am J Cardiol. 1987;60:48J-52J.
44. Higgitt A, Lader M, Fonagy P. The effects of the benzodiazepine antagonist Ro 15-1788 on psychophysiological performance and subjective measures in normal subjects. Psychopharmacology (Berlin). 1986;89:395-403.
45. Duka T, Ackenheil M, Noderer J, Doenicke A, Dorow R. Changes in noradrenaline plasma levels and behavioural responses induced by benzodiazepine agonists with the benzodiazepine antagonist Ro 15-1788. Psychopharmacology (Berlin). 1986;90:351-357.
46. Vellucci SV, Webster RA. Is Ro 15-1788 a partial agonist at benzodiazepine receptors? Eur J Pharmacol. 1983;90:263-268.
47. Jensen LH, Petersen EN, Braestrup C, Honore T, Kehr W, Stephens DN, Schneider H, Seidelmann D, Schmiechen R. Evaluation of the β-carboline ZK 93426 as a benzodiazepine receptor antagonist. Psychopharmacology (Berlin). 1984;83:249-256.
48. Charney DS, Heninger GR. Abnormal regulation of noradrenergic function in panic disorders. Am J Psychiatry. 1986;43:1042-1054.
49. Nutt DJ. Altered central alpha-2-adrenoceptor sensitivity in panic disorder. Arch Gen Psychiatry. 1989;46:165-169.
50. Villacres EC, Hollifield M, Katon WJ, Wilkinson CW, Veith RC. Sympathetic nervous system activity in panic disorder. Psychiatry Res. 1987;21:313-321.
51. Kahn RS, Asnis G M, Wetzler S, van Praag H. Neuroendocrine evidence for serotonin receptor hypersensitivity in panic disorder. Psychopharmacology (Berlin). 1988;96:360-364.
52. Nutt DJ, Glue P, Lawson CW. The neurochemistry of anxiety: an update. Prog Neuropsychopharmacol Biol Psychiatry. In press.
53. Nutt DJ. The pharmacology of human anxiety. Pharmacol Ther. 1990;47:233-266.
54. Malpas A, Legg NJ, Scott DF. Effects of hypnotics on anxious patients. Br J Psychiatry. 1974;124:482-484.
55. Roy-Byrne PP, Lewis N, Villacres E, Diem H, Greenblatt DJ, Shader RI, Veith RC. Preliminary evidence of benzodiazepine subsensitivity in panic disorder. Biol Psychiatry. 1989;26:744-748.
56. Roy-Byrne PP, Cowley DS, Greenblatt DJ, Shader RI, Hommer D. Reduced benzodiazepine sensitivity in panic disorder. Arch Gen Psychiatry. 1990;47:534-538.
57. Clark DM. A cognitive approach to panic. Behav Res Ther. 1986;24:461-470.
58. Nutt DJ, Lister RG. Strain differences in the response to the benzodiazepine receptor inverse agonist (FG7142) in mice. Psychopharamcology (Berlin). 1988;94:435-436.
59. Robertson HA, Martin IL, Candy JM. Differences in benzodiazepine receptor binding in Maudsley reactive and Maudsley non-reactive rats. Eur J Pharmacol. 1978;50:455-457.
60. Torgersen S. Genetic factors in anxiety disorders. Arch Gen Psychiatry. 1983;40:1085-1089.
61. Slater E, Shields J. Genetical aspects of anxiety. In: Lader MH, ed. Studies of Anxiety. Kent, England: Headley Brothers Ltd; 1969:62-71.
62. Roy-Byrne PP, Geraci M, Uhde TW. Life events and the onset of panic disorder. Am J Psychiatry. 1986;143:1424-1427.
63. Paul SM, Skolnick P. Rapid changes in brain benzodiazepine receptors after experimental seizures. Science. 1978;202:892-894.
64. Nutt DJ, Minchin MCW. Studies on [3H]-diazepam and [3H]ethyl-Bcarboline-3-carboxylate binding to rat brain in vivo, II: effects of electroconvulsive shock. J Neurochem. 1983;41:1513-1517.
65. Miller LG, Thompson ML, Greenblatt DJ, Deutsch SI, Shader RI, Paul SM. Rapid increase in brain benzodiazepine receptor binding following defeat stress in mice. Brain Res. 1987;414:395-400.