Acetate tolerance and the kinetics of acetate utilization in diabetic and nondiabetic subjects

American Journal of Clinical Nutrition

Volumn 51, Issue 1, 1990, Pages 112-118

  Akanji, Abayomi O ^a,b   Derek, T ^a   Hockaday, R ^a  

^a RADCLIFFE INFIRMARY   (United Kingdom)

^b UNIVERSITY OF IBADAN   (Nigeria)

Author keywords

Acetate; Diabetes mellitus; Metabolic alkalosis; Nonesterified fatty acids

Indexed keywords

ACETIC ACID;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; HUMAN; MALE; METABOLIC ALKALOSIS; NORMAL HUMAN; PRIORITY JOURNAL;

ACETATES; ADULT; BICARBONATES; DIABETES MELLITUS, NON-INSULIN-DEPENDENT; DIETARY FIBER; GLUCOSE; GLUCOSE TOLERANCE TEST; HUMAN; INFUSIONS, INTRAVENOUS; INSULIN; MALE; METABOLIC CLEARANCE RATE; RANDOM ALLOCATION; SUPPORT, NON-U.S. GOV'T;

EID: 0025037906     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/51.1.112     Document Type: Article

References (35)

1. Cummings JH. Microbial digestion of complex carbohydrates in man. Proc Nutr Soc 1984;43:35-44.
2. Wolin MJ. Fermentation in the rumen and human large intestine. Science 1981;213:1468.
3. Knowles SE, Jarrett IG, Filsell OH, Ballard FJ. Production and utilization of acetate in mammals. Biochem J 1974;142:402-11.
4. Seufert CD, Graf M, Janson G, Kuhn A, Soling HD. Formation of free acetate by isolated perfused livers from normal, starved and diabetic rats. Biochim Biophys Res Commun 1974;57:901-9.
5. Cash RA, Toha K, Nalin DR, Huq Z, Phillips RA. Acetate in the correction of acidosis secondary to diarrhoea. Lancet 1969;2: 302-3.
6. Ekblad H, Kero P, Takala J. Slow sodium acetate infusion in the correction of metabolic acidosis in premature infants. Am J Dis Child 1985;139:708-10.
7. Mion CM, Hegstrom RM, Boen ST, Scribner BH. Substitution of sodium acetate for sodium bicarbonate in the bath fluid for hemodialysis. Trans Am Soc Artif Intern Organs 1964;10:110-3.
8. Mansell MA, Wing AJ. Acetate or bicarbonate for hemodialysis? Br Med J 1983;287:308-9.
9. Wathen RL, Keshaviah P, Hommeyer P, Cadwell K, Comty CM. The metabolic effects of hemodialysis with and without glucose in the dialysate. Am J Clin Nutr 1978;31:1870-5.
10. Buckley BM, Williamson DH. Origins of blood acetate in the rat. Biochem J 1977;166:539-45.
11. Smith RF, Humphreys S, Hockaday TDR. The measurement of plasma acetate by a manual or automated technique in diabetic and non-diabetic subjects. Ann Clin Biochem 1986;23:285-91.
12. Murthy VK, Steiner G. Hepatic acetic thiokinase: a possible regulatory step in lipogenesis. Metabolism 1972;21:213-21.
13. Anderson JW, Bridges SR. Short-chain fatty acid fermentation products of plant fibre affect glucose metabolism of isolated rat hepatocytes. Proc Soc Exp Biol Med 1984;177:372-6.
14. Jarrett IG, Filsell OH. Acetate tolerance in the young lamb. Nature 1960;185:418-9.
15. Hohorst HJ, Kreutz FH, Bucher TH. The content and concentrations of intermediary metabolites in the liver of rats. Biochem Z 1959;332:18-46 (in German).
16. Williamson DH, Mellanby J, Krebs HA. The determination of D(-)-b-hydroxybutyric acid and acetoacetic acid in blood. Biochem J 1962;82:90-8.
17. Kreutz FH. The enzymatic determination of glycerol. Klin Wochenschr 1962;40:362-3 (in German).
18. Shimizu S, Inoue K, Tani Y, Yamada H. Enzymatic microdetermination of serum free fatty acids. Anal Biochem 1979;98:341-5.
19. Morgan CR, Lazarow A. Immunoassay of insulin: two antibody system. Diabetes 1963;12:115-26.
20. Jeppson JO, Franzen B, Gaal AB. Simplified determination of haemoglobin Alc in diabetic patients by use of electro-focussing. In: Radola BJ, ed. Electrophoresis '79. Advanced methods: biochemical and clinical applications. Berlin: De Gruyter, 1979:655-61.
21. Kvein MHR, Nesbakken R. Acetate metabolizing capacity in man, J Oslo City Hospital 1980;30:101-4.
22. Conard V, Franckson JR, Bastenie PA, Kestens J, Kovacs L. A critical study of the coefficient of glucose assimilation after hyperglycemia induced by intravenous glucose. Arch Int Pharmacodyn Ther 1953;93:277-92 (in French).
23. Armitage P, Berry G. Statistical methods in medical research. Oxford: Blackwell, 1987.
24. Berry EM, Gupta MM, Turner SJ, Burns RR. Variation in plasma calcium with induced changes in plasma specific gravity, total protein and albumin. Br Med J 1973;4:640-3.
25. Crouse JR, Gerson CD, DeCarli LM, Lieber CS. Role of acetate in the reduction of plasma free fatty acids produced by ethanol in man. J Lipid Res 1968;9:509-12.
26. Jarrett IG, Filsell OH. An effect of glucose on acetate metabolism in sheep. Nature 1961;190:1114-5.
27. Ciaranfi E, Fonnessu A. Time course of injected acetate in normal and depancreatized dogs. Biochem J 1954;57:171-5.
28. Harper PV, Neal WB, Hlavacek GR. Acetate utilization in the dog Metabolism 1953;2:62-7.
29. Richards RH, Vreman HJ, Zager P, Feldman C, Blaschke T, Weiner MW. Acetate metabolism in normal human subjects. Am J Kidney Dis 1982;2:47-57.
30. Skutches CL, Holroyde CP, Myers RN, Paul P, Reichard GA. Plasma acetate turnover and oxidation. J Clin Invest 1979;64:708-13.
31. Ballard FJ. Supply and utilization of acetate in mammals. Am J Clin Nutr 1972;25:773-9.
32. Akanji AO, Humphreys S, Thursfield V, Hockaday TDR. The relationship of plasma acetate with glucose and other blood intermediary metabolites in non-diabetic and diabetic subjects. Clin Chim Acta (in press).
33. Asplund JM, Orskov ER, Hovell FDB, Macleod NA. The effect of intra-gastric infusion of glucose, lipids or acetate on fasting nitrogen excretion and blood metabolites in sheep. Br J Nutr 1985;54: 189-95.
34. Ward RA, Warthen RL, Harding GB, Thompson LC. Comparative metabolic effects of acetate and dichloroacetate infusion in the anesthesized dog. Metabolism 1985;34:680-7.
35. Lipsky SR, Alper BJ, Rubini ME, Van Eck WF, Gordon ME. Gordon ME. The effects of alkalosis upon ketone-body formation and carbohydrate metabolism in man. J Clin Invest 1954;33:1269-76.