Oral Glutamine Accelerates Healing of the Small Intestine and Improves Outcome After Whole Abdominal Radiation

Archives of Surgery

Volumn 125, Issue 8, 1990, Pages 1040-1045

  Klimberg, V Suzanne ^a   Salloum, Rabih M ^a   Kasper, Michael ^a   Plumley, Donald A ^a   Dolson, David J ^a   Hautamaki, R Dean ^a   Mendenhall, William R ^a   Bova, Frank C ^a   Bland, Kirby I ^a   Copeland, Edward M ^a   Souba, Wiley W ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMINE;

ANIMAL EXPERIMENT; ARTICLE; ENZYME ACTIVITY; HISTOLOGY; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RADIATION INJURY; RAT; ULTRASTRUCTURE; WOUND HEALING;

ADMINISTRATION, ORAL; ANALYSIS OF VARIANCE; ANIMAL; COMPARATIVE STUDY; DISEASE MODELS, ANIMAL; ENTERITIS; GLUTAMINE; GLYCINE; INTESTINAL MUCOSA; INTESTINE, SMALL; JEJUNUM; MALE; RADIATION INJURIES, EXPERIMENTAL; RATS; RATS, INBRED STRAINS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0025033330     PISSN: 00040010     EISSN: 15383644     Source Type: Journal    
DOI: 10.1001/archsurg.1990.01410200104017     Document Type: Article

References (24)

1. DeCosse JJ, Rhodes RD, Wentz WB, et al. The natural history and management of radiation induced injury of the gastrointestinal tract. Ann Surg. 1969;170:369.
2. Berthrong M. Pathological changes secondary to radiation. World J Surg. 1986;10:155-170.
3. Souba WW, Scott TE, Wilmore DW. Intestinal consumption of intravenously administered fuels. JPEN J Parenter Enteral Nutr. 1985;9:18.
4. Windmueller HG. Glutamine utilization by the small intestine. Adv Enzymol. 1982;53:202.
5. Souba WW, Smith RJ, Wilmore DW. Glutamine metabolism by the intestinal tract. JPEN J Parenter Enteral Nutr. 1985;9:608-617.
6. Windmueller HG, Spaeth AE. Respiratory fuels and nitrogen metabolism in vivo in the small intestine of fed rats. J Biol Chem. 1980;255:107.
7. Souba WW, Wilmore DW. Gut-liver interaction during accelerated gluconeogenesis. Arch Surg. 1985;120:66.
8. Souba WW, Wilmore DW. Postoperative alteration of arteriovenous exchange of amino acids across the gastrointestinal tract. Surgery. 1985;94:342.
9. Souba WW. Glutamine Metabolism in Catabolic States: Role of the Intestinal Tract. Boston, Mass: Department of Nutritional Biochemistry, Harvard School of Public Health; 1984. Thesis.
10. Fox AD, Kripke SA, Berman JR, et al. Reduction of the severity of enterocolitis by glutamine-supplemented enteral diets. Surg Forum. 1987;38:43.
11. Fox AD, DePaula JA, Kripke SA, et al. Glutamine-supplemented elemental diets reduce endotoxemia in a lethal model of enterocolitis. Surg Forum. 1988;39:46.
12. Souba WW, Strebel FR, Bull JM, et al. Interorgan glutamine metabolism in the tumor-bearing rat. J Surg Res. 1988;44:720-726.
13. Klimberg VS, Souba WW, Hautamaki RD, et al. Prophylactic glutamine protects the intestine from radiation. Cancer. In press.
14. Hwang TL, O'Dwyer ST, Smith RJ, Wilmore DW. Preservation of small bowel mucosa using glutamine-enriched parenteral nutrition. Surg Forum. 1987;38:56.
15. Okabe S, Honda K, Takeuchi K, et al. Inhibitory effect of L-glutamine on gastric irritation and back diffusion of gastric acid in response to aspirin in the rat. Dig Dis. 1975;20:626.
16. Klimberg VS, Souba WW, Dolson DJ, Copeland EM. Oral glutamine supports crypt cell turnover and accelerates intestinal healing following abdominal radiation. JPEN J Parenter Enteral Nutr. 1989;13:115. Abstract.
17. Guxman G, Bonsack M, Liberty J, Delaney JP. Abdominal radiation causes bacterial translocation. J Surg Res. 1989;46:104-107.
18. Bergmeyer HU, ed. Methods of Enzymatic Analysis. New York, NY: John Wiley & Sons Inc; 1974;4:1704-1708.
19. Pinkus LM, Windmueller HA. Phosphate-dependent glutaminase of small intestine: localization and role in glutamine metabolism. Arch Biochem Biophys. 1977;182:506-517.
20. Lowry OH, Rosenbrough WJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem. 1951;193:265-275.
21. Souba WW, Klimberg VS, Hautamaki RD, et al. Oral glutamine reduces bacterial translocation following abdominal radiation. J Surg Res. 1990;48: 319-323.
22. O'Dwyer ST, Scott T, Smith RJ, Wilmore DW. 5-Fluorouacil toxicity on small intestinal mucosa but not white blood cells is decreased by glutamine. Clin Res. 1987;35:369a. Abstract.
23. Jacobs DO, Evans A, O'Dwyer ST, Smith RJ, Wilmore DW. Disparate effects of 5-fluorouracil on the ileum and colon of enterally fed rats with protection by dietary glutamine. Surg Forum. 1987;38:45-49.
24. Frissell WR. Synthesis and catabolism of nucleotides. In: Firsell WR, ed. Human Biochemistry. New York, NY: Macmillan Publishing Co Inc; 1982:292-304.