Synthesis and Evaluation of α-[[(2-Haloethyl)amino]methyl]-2-nitro-1H-imidazole-l-ethanols as Prodrugs of α-[(l-Aziridinyl)methyl]-2-nitro-1H-imidazole-1-ethanol (RSU-1069) and its Analogues Which Are Radiosensitizers and Bioreductively Activated Cytotoxins

Journal of Medicinal Chemistry

Volumn 33, Issue 9, 1990, Pages 2603-2610

  Jenkins, Terence C ^a   Naylor, Matthew A ^a   O'Neill, Peter ^a   Threadgill, Michael D ^a   Cole, Shirley ^a   Stratford, Ian J ^a   Adams, Gerald E ^a   Fielden, E Martin ^a   Suto, Mark J ^b   Stier, Michael A ^b  

^a Medical Research Council Radiobiology Unit ^*  (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 BROMOETHYLAMINO) 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL; 1 AZIRIDINO 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL; 2 NITROIMIDAZOLE DERIVATIVE; ALPHA [(1 AZIRIDINYL)METHYL] 2 NITRO 1H IMIDAZOLE 1 ETHANOL; ALPHA [(2 BROMOETHYL)AMINOMETHYL] 2 NITRO 1H IMIDAZOLE 1 ETHANOL; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL MODEL; CELL STRAIN V 79; CYTOTOXICITY; DRUG SCREENING; DRUG STABILITY; DRUG SYNTHESIS; HAMSTER; HYPOXIA; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL; RADIOSENSITIZATION;

ANIMAL; ANTINEOPLASTIC AGENTS; CHEMISTRY; CYTOTOXINS; MICE; MICE, INBRED C3H; MISONIDAZOLE; NEOPLASMS, EXPERIMENTAL; PRODRUGS; RADIATION-SENSITIZING AGENTS; SUPPORT, NON-U.S. GOV'T;

EID: 0025023154     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00171a040     Document Type: Article

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