Monoclonal-antibody-mediated apoptosis in adult T-cell leukaemia

The Lancet

Volumn 335, Issue 8688, 1990, Pages 497-500

  Debatin, K M ^a   Krammer, P H ^b   Goldman, C K ^c   Bamford, R ^c   Waldmann, T A ^c  

^a Oncology/Immunology Section University Children's Hospital ^*  (United Kingdom)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; ARTICLE; CELL CULTURE; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS; PRIORITY JOURNAL; T CELL LEUKEMIA;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD95; ANTIGENS, NEOPLASM; ANTIGENS, SURFACE; CELL DIVISION; CELL LINE, TRANSFORMED; CELL SURVIVAL; CELL TRANSFORMATION, VIRAL; FLUORESCENT ANTIBODY TECHNIQUE; HUMAN; IMMUNOGLOBULIN G; IN VITRO; LEUKEMIA, T-CELL; MEMBRANE PROTEINS; PHENOTYPE; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTES; TUMOR CELLS, CULTURED;

EID: 0025021654     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/0140-6736(90)90735-N     Document Type: Article

References (14)

1. Isolation of a new type C retrovirus (HTLV) in primary uncultured cells of a patient with Sezary T-cell leukemia
2. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T cell lymphoma
3. Monoclonal integration of HTVL in all primary tumours of adult T cell leukemia suggests causative role of HTLV in the disease
4. T cell lymphoproliferative syndrome associated with human T cell leukemia/lymphoma virus
5. Augmented T cell growth factor receptor expression in HTLV-I infected human leukemic T cells
6. The interleukin-2 receptor: normal and abnormal expression in T cells and leukemias induced by the human T-lymphotrophic retroviruses
7. Autocrine growth of interleukin-2 producing cells in a patient with adult T cell leukemia
8. Transacting transcriptional activation of the long terminal repeat of human T lymphotrophic viruses in infected cells
9. Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-I encode p40 and T3/Ti complex tiggering.
10. Activation of interleukin-2 and interleukin-2 receptor (Tac) promoter expression by the transactivator (tat) gene product of human T cell leukemia virus, type I
11. Monoclonal antibody-induced tumor regression by activation of an endogenous suicide programme.
12. Death and the cell
13. Leukemic cells from some adult T cell leukemia patients proliferate in response to interleukin-4
14. Therapy of patients with human T cell lymphotrophic virus I-induced adult T cell leukemia with anti-Tac, a monoclonal antibody to the receptor for interleukin-2