The biological role of the carboxyl-terminal extension of human chorionic gonadotroin/3-subunit

Endocrinology

Volumn 126, Issue 1, 1990, Pages 376-383

  Matzuk, M M ^a,c   Hsueh, A J W ^a,b   Lapolt, P ^a,b   Tsafriri, A ^a,b   Keene, J L ^a,d   Boime, I ^a,a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^d MONSANTO COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN; CHORIONIC GONADOTROPIN DERIVATIVE; CYCLIC AMP; LUTEINIZING HORMONE RECEPTOR; PROGESTERONE; RADIOISOTOPE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; DRUG ACTIVITY; FEMALE; HAMSTER; NONHUMAN; OVARY; OVULATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMAL; CELL LINE; CHEMISTRY; CHORIONIC GONADOTROPIN; FEMALE; GENES; GONADOTROPINS, EQUINE; HUMAN; HYPOPHYSECTOMY; INJECTIONS; INJECTIONS, INTRAVENOUS; MUTATION; OVARY; OVULATION; RECEPTORS, GONADOTROPIN; SIGNAL TRANSDUCTION; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0025020754     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/endo-126-1-376     Document Type: Article

References (48)

1. Pierce JG, Parsons TF 1981 Glycoprotein hormones: Structure and function. Annu Rev Biochem 50:465
2. Shome B, Parlow AF 1973 The primary structure of the hormone- specific, beta subunit of human pituitary luteinizing hormone (hLH). J Clin Endocrinol Metab 36:618
3. Talmadge K, Vamvakopoulos NC, Fiddes JC 1984 Evolution of the genes for the β subunits of human chorionic gonadotropin and luteinizing hormone. Nature 307:37
4. Birken S, Canfield RE 1977 Isolation and amino acid sequence of COOH-terminal fragments from the β subunit of human chorio-gonadotropin. J Biol Chem 252:5386
5. Keutmann HT, Williams RM 1977 Human chorionic gonadotropin sequence: Amino acid sequence of the hormone-specific COOH- terminal region. J Biol Chem 252:5393
6. Kessler MJ, Mise T, Ghai RD, Bahl OP 1979 Structure and location of the O-glycosidic carbohydrate units of human chorionic gonad-otropin. J Biol Chem 254:7909
7. Braunstein GD, Vaitukaitis JL, Ross GT 1972 The in uiuo behavior of human chorionic gonadotropin after dissociation into subunits. Endocrinology 91:1030
8. de Kretser DM, Atkins RC, Paulsen CA 1973 Role of the kidney in the metabolism of luteinizing hormone. J Endocrinol 58:425
9. Sowers JR, Pekary AE, Hershman JM, Kanter M, DiStefano III JJ 1979 Metabolism of exogenous human chorionic gonadotropin in men. J Endocrinol 80:83
10. Kalyan NK, Bahl OP 1983 Role of carbohydrate in human chorionic gonadotropin: Effect of deglycosylation on the subunit interaction and on its in vitro and in vivo biological properties. J Biol Chem 258:67
11. Canfield RE, Birken S, Morse JH, Morgan FJ 1978 Human chorionic gonadotropin. In: Parsons JA (ed) Peptide Hormones. University Park Press, Baltimore, pp 299-315
12. Combarnous Y, Guillou F, Martinot N 1986 Functional states of the luteinizing hormone/choriogonadotropin-receptor complex in rat Leydig cells. J Biol Chem 261:6868
13. Ryan RJ, Keutmann HT, Charlesworth MC, McCormick DJ, Mil- ius RP, Calvo RO, Vutyavanich T 1987 Structure-function relationships of gonadotropins. Recent Prog Horm Res 43:383
14. Wallis M, Howell SL, Taylor KW 1985 The Biochemistry of the Polypeptide Hormones. Wiley and Sons, New York, p 147
15. Louvet J-P, Ross GT, Birken S, Canfield RE 1974 Absence of neutralizing effect of antisera to the unique structural region of human chorionic gonadotropin. J Clin Endocrinol Metab 39:1155
16. Berger P, Kofler R, Wick G 1984 Monoclonal antibodies against human chorionic gonadotropin (hCG): II. Affinity and ability to neutralize the biological activity of hCG. Am J Reprod Immunol 5:157
17. Ehrlich PH, Moustafa ZA, Krichevsky A, Birken S, Armstrong EG, Canfield RE 1985 Characterization and relative orientation of epitopes for monoclonal antibodies and antisera to human chorionic gonadotropin. Am J Reprod Immunol 8:48
18. Armstrong EG, Birken S, Moyle WR, Canfield RF 1985 Immuno- chemistry of human chorionic gonadotropin. In: Litwack G (ed) Biochemical Actions of Hormones. Academic Press, Orlando, vol 13:91
19. Bidart J-M, Troalen F, Bohuon CJ, Henner G, Bellet DH 1987 Immunochemical mapping of a specific domain on human chorio-gonadotropin using anti-protein and anti-peptide monoclonal an-tibodies. J Biol Chem 262:15483
20. Kingsley DM, Kozarsky KF, Hobbie L, Krieger M 1986 Reversible defects in O-linked glycosylation and LDL receptor expression in a UDP-Gal/UDP GalNAc 4-Epimerase deficient mutant. Cell 44:749
21. Matzuk MM, Krieger M, Corless CL, Boime I 1987 Effects of preventing O-glycosylation on the secretion of human chorionic gonadotropin in Chinese hamster ovary cells. Proc Natl Acad Sci USA 84:6354
22. Matzuk MM, Boime I 1988 The role of the asparagine-linked oligosaccharides of the a-subunit in the secretion and assembly of human chorionic gonadotropin. J Cell Biol 106:1049
23. Ascoli M 1985 Luteinizing Hormone Actions and Receptors. CRC Press, Boca Raton, p 199
24. Segaloff DL, Puett D, Ascoli M 1981 The dynamics of the steroi-dogenic response of perfused Leydig tumor cells to human chorionic gonadotropin, bovine luteinizing hormone, cholera toxin, and aden-osine 3’, 5’-cyclic monophosphate. Endocrinology 108:632
25. + modulates the affinity of the lutropin/choriogonadotropin receptor. J Biol Chem 259:15078
26. Pereira ME, Segaloff DL, Ascoli M, Eckstein F 1987 Inhibition of choriogonadotropin-activated steroidogenesis in cultured Leydig tumor cells by the Rp diastereoisomer of adenosine 3’, 5’-cyclic phosphorothioate. J Biol Chem 262:6093
27. Salacinski PRP, McLean C, Sykes JEC, Clement-Jones JJ, Lowry PJ 1981 Iodination of proteins, glycoproteins, and peptides using a solid-phase oxidizing agent, l, 3, 4, 6-tetrachloro-3α, 6α-diphenyl glycoluril (Iodogen). Anal Biochem 117:136
28. Matzuk MM, Boime I 1989 Mutagenesis and gene transfer define site-specific roles of the gonadotropin oligosaccharides. Biol Reprod 40:48
29. Matzuk MM, Spangler MM, Camel M, Suganuma N, Boime I, 1989 Mutagenesis and chimeric genes define determinants in the P subunits of human chorionic gonadotropin and lutropin for secretion and assembly. J Cell Biol, 109:1429
30. Moyle WR, Bahl OP, Marz L 1975 Role of the carbohydrate of human chorionic gonadotropin in the mechanism of hormone action. J Biol Chem 250:9163
31. Goverman JM, Parsons JF, Pierce JG 1982 Enzymatic deglycosy-lation of the subunits of chorionic gonadotropin. J Biol Chem 257:15059
32. Chen H.-C., Shimohigoshi Y, Dufau ML, Catt KJ 1982 Character-ization and biological properties of chemically deglycosylated human chorionic gonadotropin. J Biol Chem 257:14446
33. Keutmann HT, McLlroy PJ, Bergert ER, Ryan RJ 1983 Chemically deglycosylated human chorionic gonadotropin subunits: Character-izations and biological properties. Biochemistry 22:3067
34. Matzuk MM, Keene JL, Boime I 1989 Site specificity of the chorionic gonadotropin N-linked oligosaccharides in signal transduction. J Biol Chem 264:2409
35. Strickland TW, Puett D 1981 Contribution of subunits to the function of luteinizing hormone/human chorionic gonadotropin recombinants. Endocrinology 109:1933
36. Niswender GD, Roess DA, Sawyer HR, Silvia WJ, Barisas BG 1985 Differences in the lateral mobility of receptors for luteinizing hormone (LH) in the luteal cell plasma membrane when occupied by ovine LH versus human chorionic gonadotropin. Endocrinology 116:164
37. Podesta EJ, Solano A, Attar R, Sanchez ML, Molina Y, Vedia L 1983 Receptor aggregation induced by antilutropin receptor antibody and biological response in rat Leydig cells. Proc Natl Acad Sci USA 80:3986
38. Calvo FO, Ryan RJ 1985 Inhibition of adenyl cyclase activity in rat corpora luteal tissue by glycopeptides of human chorionic gonadotropin and the α-subunit of human chorionic gonadotropin. Biochemistry 24:1953
39. Mock EJ, Papkoff H, Niswender GD 1983 Internalization of ovine luteinizing hormone/human chorionic gonadotropin recombinants: Differential effects of the α- and β-subunits. Endocrinology 113:265
40. Ascoli M, Segaloff DL 1987 On the fates of receptor-bound ovine luteinizing hormone and human chorionic gonadotropin in cultured Leydig tumor cells: Demonstration of similar rates of internaliza-tion. Endocrinology 120:1161
41. Ascoli M, Liddle RA, Puett D 1975 The metabolism of luteinizing hormone. Plasma clearance, urinary excretion, and tissue uptake. Mol Cell Endocrinol 3:21
42. Constant RB, Weintraub BD 1986 Differences in the metabolic clearance of pituitary and serum thyrotropin (TSH) derived from euthyroid and hypothyroid rats: Effects of chemical deglycosylation of pituitary TSH. Endocrinology 119:2720
43. Amin HK, Hunter WM 1970 Human pituitary follicle-stimulating hormone: Distribution, plasma clearance and urinary excretion as determined by radioimmunoassay. J Endocrinol 48:307
44. Wide L 1986 The regulation of metabolic clearance rate of human FSH in mice by variation of the molecular structure of the hormone. Acta Endocrinol (Copenh) 112:336
45. Krystek SR Jr, Reichert LE Jr, Andersen TT 1985 Analysis of computer-generated hydropathy profiles for human glycoprotein and lactogenic hormones. Endocrinology 117:110
46. Keene JL, Matzuk MM, Boime I, Expression of recombinant human choriogonadotropin in Chinese hamster ovary glycosylation mutants. Mol Endocrinol, in press
47. Sugino H, Bousfield GR, Moore WT Jr, Ward DN 1987 Structural studies on equine glycoprotein hormones: Amino acid sequence of equine chorionic gonadotropin β subunit. J Biol Chem 262:8603
48. Bousfield GR, Liu W-K, Sugino H, Ward DN 1987 Structural studies on equine glycoprotein hormones: Amino acid sequence of equine lutropin β-subunit. J Biol Chem 262:8610