Influence of high density lipoprotein on esterified cholesterol stores in macrophages and hepatoma cells

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 10, Issue 1, 1990, Pages 135-144

  Bernard, David W ^a   Rodriguez, Annabelle ^a   Rothblat, George H ^a   Glick, Jane M ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Cholesterol efflux; Cholesteryl ester clearance; Fu5AH cells; High density lipoproteins; J774 cells; Macrophage cholesterol metabolism; P388.D1 cells

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN;

ANIMAL CELL; ARTICLE; CELL CULTURE; LIVER CELL CARCINOMA; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; CELLS, CULTURED; CHOLESTEROL; CHOLESTEROL ESTERS; LIPOPROTEINS, HDL; LIVER NEOPLASMS, EXPERIMENTAL; MACROPHAGES; MICE; PERITONEAL CAVITY; RATS; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0025020497     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.10.1.135     Document Type: Article

References (47)

1. Rosenfeld ME, Tsukada T, Chalt A, Bierman EL, Gown AM, Ross R. Fatty streak expansion and maturation in Watanabe heritable hyperlipemic and comparably hypercholesterolemic fat-fed rabbits. Arteriosclerosis 1987;7:24-34
2. Rosenfeld ME, Tsukada T, Gown AM, Ross R. Fatty streak initiation in Watanabe heritable hyperlipemic and comparably hypercholesterolemic fat-fed rabbits. Arteriosclerosis 1987;7:9-23
3. Reichl D, Miller NE. The anatomy and physiology of reverse cholesterol transport. Clin Sci 1986;70:221-231
4. Phillips MC, Johnson WJ, Rothblat GH. Mechanism and consequence of cellular cholesterol exchange and transfer. Biochim Biophys Acta 1987;906:223-276
5. Brown MS, Ho YK, Goldsteln JL. The cholesteryl ester cycle in macrophage foam cells. Continual hydrolysis and re-esterification of cytoplasmic cholesteryl esters. J Biol Chem 1980;255:9344-9352
6. Via DP, Plant AL, Craig IF, Gotto AM, Smith LC. Metabolism of normal and modified low-density lipoproteins by macrophage cell lines of murine and human origin. Biochim Biophys Acta 1985;833:417-428
7. Click JM, Adelman SA, Rothblat GH. Cholesteryl ester cycle in cultured hepatoma cells. Atherosclerosis 1987;64:223-230
8. Freeman DA. Regulation of the cholesterol ester cycle of cultured Leydig tumor cells. Eur J Biochem 1987;164:351-356
9. Ho YK, Brown MS, Goldsteln JL. Hydrolysis and excretion of cytoplasmic cholesteryl esters by macrophages: stimulation by high density lipoprotein and other agents. J Lipid Res 1980;21:391-398
10. Lindqvist P, Ostlund-Lindqvist A, Witztum JL, Steinberg D, Little JA. The role of lipoprotein lipase in the metabolism of trigiyceride-rich lipoproteins by macrophages. J Biol Chem 1983;258:9086-9092
11. Mazzone T, Gump H, Diller P, Getz GF. Macrophage free cholesterol content regulates apolipoprotein E synthesis. J Biol Chem 1987;262:11657-11662
12. Mathur SN, Field FJ, Megan MB, Armstrong ML. A defect in mobilization of cholesteryl esters in rabbit macrophages. Biochim Biophys Acta 1985;834:48-57
13. Randolph RK, Hoff HF. Exchange and mass efflux of cholesterol in macrophages. Evidence for a common mechanism and a role for plasma membrane proteins. J Upid Res 1986;27:307-315
14. Schmitz G, Robenek H, Lohmann U, Assmann G. Interaction of high density lipoproteins with cholesteryl ester-laden macrophages: biochemical and morphological characterization of cell surface receptor binding, endocytosis and resecretion of high density lipoproteins by macrophages. EMBO J 1985;4:613-622
15. Yau-Young AO, Rothblat GH, Small DM. Mobilization of cholesterol from cholesterol ester enriched tissue culture cells by phospholipid dispersions. Biochim Biophys Acta 1982;710:181-187
16. Pitas RE, Innerarity TL, Mahley RW. Foam cells in expiants of atherosclerotic rabbit aortas have receptors for B-VLDL and modified LDL Arteriosclerosis 1983;3:2-12
17. Ralph P, Pritchard J, Cohn M. Reticulum cell sarcoma: an effector cell in antibody-dependent cell-mediated immunity. J Immunol 1975;14:898-905
18. McCloskey HM, Rothblat GH, Glick JM. Incubation of acetylated low-density lipoprotein with cholesterol-rich dispersions enhances cholesterol uptake by macrophages. Biochim Biophys Acta 1987;921:320-332
19. Tabas L, Weiland DA, Tall AR. Unmodified low density lipoprotein causes cholesteryl ester accumulation in J774 macrophages. Proc Natl Acad Sci USA 1985;82:416-420
20. Koo C, Innerarity TL, Mahley RW. Obligatory role of cholesterol and apolipoprotein E in the formation of large cholesterol-enriched receptor-active high density lipoproteins. J Biol Chem 1985;260:11934-11943
21. Khoo JC, Mahoney EM, Steinberg D. Neutral cholesterol esterase activity in macrophages and its enhancement by CAMP dependent protein kinase. J Biol Chem 1981;256:12659-12661
22. Dulbecco R, Vogt M. Plaque formation and isolation of pure lines with poliomyelitis viruses. J Exp Med 1954;99:167-182
23. Glick JM, Adelman SJ, Phillips MC, Rothblat GH. Cellular cholesteryl ester clearance: relationship to the physical state of cholesteryl ester inclusions. J Biol Chem 1983;258:13425-13430
24. Hatch FT, Lees RS. Practical methods for plasma lipoprotein analysis. Adv Lipid Res 1968;6:1-68
25. Johnson WJ, Bamberger MJ, Latta RA, Rapp PE, Phillips MC, Rothblat GH. The bidirectional flux of cholesterol between cells and lipoproteins. J Biol Chem 1986;261:5766-5776
26. Fraenkel-Conrat H. Methods for investigating the essential groups for enzyme activity. Meth Enzymol 1957;4:247-269
27. Noble RP. Electrophoretic separation of plasma lipoproteins In agarose gels. J Lipid Res 1968;9:693-700
28. Bamberger MJ, Glick JM, Rothblat GH. Hepatic lipase stimulates the uptake of high density lipoprotein cholesterol by hepatoma cells. J Upid Res 1983;24:869-876
29. Adelman SJ, Glick JM, Phillips MC, Rothblat GH. Upid composition and physical state effects on cellular cholesteryl ester clearance. J Biol Chem 1984;259:13844-13850
30. Cappriotti AM, Laposata M. Identification of variables critical to reproducible delipidation of serum. J Tiss Cult Meth 1986;10:219-221
31. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem 1959;37:911-917
32. Ishikawa TT, MacGee J, Morrison JA, Glueck CJ. Quantitative analysis of cholesterol in 5 to 20 μl of plasma. J Upid Res 1974;15:286-291
33. Sokoloff L, Rothblat GH. Regulation of sterol synthesis in L-cells: steady-state and transitional responses. Biochim Biophys Acta 1972;280:171-181
34. Markwell MAK, Haas SM, Bieber LL, Tolbert NE. A modification of the Lowry procedure to simplify protein determi-nation in membrane and lipoprotein samples. Anal Biochem 1978;87:206-210
35. Rothblat GH, Rosen JM, Insull W Jr, Yau AO, Small DM. Production of cholesteryl ester-rich anisotropic inclusions by mammalian cells in culture. Exp Mol Pathol 1977;26:318-324
36. Runyon RP. Fundamentals of statistics in the biological, medical, and health sciences. Boston: PWS Publishers, 1985:170-171
37. Brown MS, Goldstein JL. Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. Annu Rev Biochem 1983;52:223-261
38. Karlin JB, Johnson WJ, Benedict CR, Chacko GK, Phillips MC, Rothblat GH. Cholesterol flux between cells and high density lipoprotein: lack of relationship to specific binding of the lipoprotein to the cell surface. J Biol Chem 1987;262:12557-12564
39. Bamberger M, Lund-Katz S, Phillips MC, Rothblat GH. Mechanism of the hepatic lipase induced accumulation of high density lipoprotein cholesterol by cells in culture. Biochemistry 1985;24:3693-3701
40. Tabas I, Boykow GC, Tall AR. Foam cell-forming J774 macrophages have markedly elevated acyl coenzyme A: cholesterol acyl transferase activity compared with mouse peritoneal macrophages in the presence of low density lipoprotein (LDL) despite similar LDL receptor activity. J Clin Invest 1987;79:418-426
41. Tabas L, Weiland DA, Tall AR. Inhibition of ACAT in J774 macrophages enhances down-regulation of the low density lipoprotein receptor and HMG CoA reductase and prevents LDL-induced cholesterol accumulation. J Biol Chem 1986;261:3147-3155
42. Basu SK, Goldstein JL, Brown MS. Independent pathways for secretion of cholesterol and apolipoprotein by macrophages. Science 1983;219:871-873
43. Werb Z, Chin JR. Onset of apoprotein E secretion during differentiation of mouse bone marrow-derived mononuclear phagocytes. J Cell Bio 1983;97:1113-1118
44. Reardon CA, Lau YF, Paik YH, Welsgraber KH, Mahley RW, Taylor JM. Expression of the human apolipoprotein E gene in cultured mammalian cells. J Biol Chem 1986;261:9858-9864
45. Diller PM, Wissler RW, Getz GS. Synthesis of modified apo E by Fu5AH rat hepatoma and its induction by cholesterol loading [abstr]. Arteriosclerosis 1985;5:550A
46. Graham DL, Oram JF. Identification and characterization of a high density lipoprotein-binding protein in cell membranes by ligand blotting. J Biol Chem 1987;262:7439-7442
47. Aviram M, Bierman EL, Oram JF. High density lipoprotein stimulates sterol translocation between intracellular and plasma membrane pools in human monocyte-derived macrophages. J Upid Res 1989;30:65-76