Long‐term trial with the oral iron chelator 1,2‐dimethyl‐3‐hydroxypyrid‐4‐one (L1) I. IRON CHELATION AND METABOLIC STUDIES

British Journal of Haematology

Volumn 76, Issue 2, 1990, Pages 295-300

  Kontoghiorghes, G J ^a   Bartlett, A N ^a   Hoffbrand, A V ^a   Goddard, J G ^a   Sheppard, L ^a   And, J Barr ^a   Nortey, P ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DEFERIPRONE;

ARTICLE; CLINICAL ARTICLE; HUMAN; HUMAN EXPERIMENT; IRON CHELATION; IRON OVERLOAD; MYELODYSPLASIA; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; THALASSEMIA;

ANEMIA; BLOOD TRANSFUSION; FERRITIN; HALF-LIFE; HUMAN; IRON; IRON CHELATING AGENTS; MYELODYSPLASTIC SYNDROMES; PYRIDONES; SUPPORT, NON-U.S. GOV'T; THALASSEMIA;

EID: 0025018222     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.1990.tb07887.x     Document Type: Article

References (29)

1. 1
2. 1). II. Clinical observations
3. Development of an HPLC method for measuring orally administered l‐substituted‐2‐alkyl‐3‐hydroxypyrid‐4‐one iron chelators in biological fluids
4. The development of new iron chelating drugs (ii)
5. Improvement in iron status and liver function with chronic subcutaneous desferrioxamine therapy
6. New orally active iron chelators
7. Orally active α‐ketohydroxypyridine iron chelators: studies in mice
8. Dose response studies using desferrioxamine and orally active chelators in a mouse model
9. 1, 1.2‐dimethyl‐3‐hydroxypyrid‐4‐one
10. Effective chelation of iron in β‐thalassaemia with the oral chelator 1,2‐dimethyl‐3‐hydroxypyrid‐4‐one
11. 1.2‐Dimethy1‐3‐hydroxypyrid‐4‐one, an orally active chelator for treatment of iron overload
12. Prospects for effective oral iron chelation therapy in man with 1,2‐dimethyl‐3‐hydroxypyrid‐4‐one and other α‐ketohydroxypyridines
13. Orally active α‐ketohydroxypyridine iron chelators intended for clinical use: In vivo studies in rabbits
14. Prospects for effective and oral chelation in transfusional iron overload
15. 1
16. Simple synthesis of the potent iron chelators l‐alkyl‐3‐hydroxy‐2‐methylpyrid‐4‐ones
17. Study of free amino acids in the seeds of Leucaena glauca Benth. III. Biological study of mimosine
18. 1 in patients with thalassemia major. Iron balance and dose response studies
19. Ferrioxamine excretion in iron loaded man
20. The design and synthesis of chelating agents for the treatment of iron overload in Cooleys Anaemia
21. 1
22. The metabolism of ethyl maltol andmaltol in the dog
23. Effects of metals on the absorption and excretion of mimosine and 3,4‐dihydroxypyridine in rat in vivo
24. Study of the stability constant of some metal ion chelates of mimosine and 3,4‐dihydroxypyridine
25. 1 in rheumatoid arthritis patients