Eponemycin, a new antibiotic active against B16 melanoma. I. Production, isolation, structure and biological activity

The Journal of Antibiotics

Volumn 43, Issue 1, 1990, Pages 8-18

  Sugawara, Koko ^a   Hatori, Masami ^a   Nishiyama, Yuji ^a   Tomita, Koji ^a   Kamei, Hideo ^a   Konishi, Masataka ^a   Oki, Toshikazu ^a  

^a Tokyo Research Center ^*  (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DIACETYLEPONEMYCIN; DIHYDROEPONEMYCIN; EPONEMYCIN; MITOMYCIN C; TETRAHYDROEPONEMYCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CULTURE; CYTOTOXICITY; DRUG ISOLATION; DRUG MANUFACTURE; DRUG STRUCTURE; FUNGUS; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; LEUKEMIA L 1210; LEUKEMIA P 388; MELANOMA B16; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; STREPTOMYCES HYGROSCOPICUS;

AMIDES; ANIMAL; ANTIBIOTICS, ANTINEOPLASTIC; DNA, NEOPLASM; FERMENTATION; HUMAN; LEUKEMIA L1210; LEUKEMIA P388; MELANOMA, EXPERIMENTAL; MICE; MOLECULAR STRUCTURE; RNA, NEOPLASM; SERINE; STREPTOMYCES; TUMOR CELLS, CULTURED;

EID: 0025015309     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.7164/antibiotics.43.8     Document Type: Article

References (3)

1. Pridham, T. G. & H. D. Tresner: Genus I. Streptomyces Waksman and Henrici, 1943 399. In BERGEY'S Manual of Determinative Bacteriology, 8th Ed. Eds., R. E. Buchanan & N. E. Gibbons, pp. 748~829, Williams & Wilkins Co., 1974.
2. Saito, N.; F. Kitame, M. Kikuchi & N. Ishida: Studies on a new antiviral antibiotic, 9-methylstreptimidone. I. Physicochemical and biological properties. J. Antibiotics 27: 206~214, 1974.
3. Emmons, W. D. & G. B. Lucas: Peroxytrifluoroacetic acid. V. The oxidation of ketones to esters. J. Am. Chem. Soc. 77: 2287~2288, 1955.