Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives

Nature

Volumn 343, Issue 6257, 1990, Pages 470-474

  Pauwels, Rudi ^a   Andries, Koen ^b   Desmyter, Jan ^a   Schols, Dominique ^a   Kukla, Michael J ^c   Breslin, Henry J ^c   Raeymaeckers, Alfons ^b   Gelder, Jozef Van ^b   Woestenborghs, Robert ^b   Heykants, Jozef ^b   Schellekens, Karel ^b   Janssen, Marcel A C ^b   Clercq, Erik De ^a   Janssen, Paul A J ^b  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b JANSSEN RESEARCH FOUNDATION   (Belgium)

^c Janssen Research and Development   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4,5,6,7 TETRAHYDRO 5 METHYL 6 (3 METHYL 2 BUTENYL)IMIDAZO[4,5,1 JK][1,4]BENZODIAZEPINE 2(1H) THIONE; 4,5,6,7 TETRAHYDROIMIDAZO[4,5,1 JK][1,4]BENZODIAZEPINE 2(1H) ONE DERIVATIVE; 4,5,6,7 TETRAHYDROIMIDAZO[4,5,1 JK][1,4]BENZODIAZEPINE 2(1H) THIONE DERIVATIVE; DIDANOSINE; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG; ZALCITABINE; ZIDOVUDINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; HUMAN IMMUNODEFICIENCY VIRUS; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION;

ANIMAL; ANTIVIRAL AGENTS; BENZODIAZEPINES; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; COMPARATIVE STUDY; CYTOPATHOGENIC EFFECT, VIRAL; DIDANOSINE; DOGS; HIV-1; HIV-2; HUMAN; IMIDAZOLES; LYMPHOCYTES; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; REVERSE TRANSCRIPTASE INHIBITORS; SUPPORT, NON-U.S. GOV'T; VIRUS REPLICATION; ZIDOVUDINE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; RNA VIRUSES;

EID: 0025014499     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/343470a0     Document Type: Article

References (25)

1. Barré-Sinoussi, F., et al. Science 220, 868-871 (1983).
2. Gallo, R. C., et al. Science 224, 500-503 (1984).
3. Clavel, F., et al. Science 233, 343-346 (1986).
4. Balzarini, J. & Broder, S. in Clinical Use of Antiviral Drugs (ed. De Clercq, E.) 361-385 (Martinus Nijhoff. Boston, 1988).
5. Mitsuya, H., et al. Proc. natn. Acad. Sci. U.S.A. 82, 7096-7100 (1985).
6. Chu, C. K., et al. Biochem. Pharmac. 37, 3543-3548 (1988).
7. Pauwels, R., et al. J. virol. Meth. 20, 309-321 (1988).
8. De Clercq, E. Antiviral Res. 12, 1-20 (1989).
9. Janssen, P. A. J., et al. J. pharmacol. exp. Ther. 244, 685-693 (1988).
10. Pauwels, R., et al. J. virol. Meth. 16, 171-185 (1987).
11. Clavel, F. & Guétard, D. AIDS 1, 135-140 (1987).
12. Harada, S., Koyanagi, Y. & Yamamoto, N. Science 229, 563-566 (1985).
13. Nakashima, H., et al. J. virol. Meth. 26, 319-330 (1989).
14. Schols, D., Baba, M., Pauwels, R., Desmyter, J. & De Clercq, E. Proc. natn. Acad. Sci. U.S.A. 86, 3322-3326 (1989).
15. Dalgleish, A. G., et al. Nature 312, 763-767 (1984).
16. Baba, M., et al. Proc. natn. Acad. Sci. U.S.A. 85, 6132-6136 (1988).
17. Mitsuya, H., et al. Science 240, 646-649 (1988).
18. Schols, D., Baba, M., Pauwels, R. & De Clercq, E. J. AIDS 2, 10-15 (1989).
19. Schols, D., Pauwels, R., Baba, M., Desmyter, J. & De Clercq, E. J. gen. Virol. 70, 2397-2408 (1989).
20. Baba, M., et al. Antivir. Res. 9, 335-343 (1988).
21. Starcich, B. R., et al. Cell 45, 637-648 (1986).
22. Clavel, F., et al. Nature 324, 691-695 (1986).
23. Rey, M., et al. Virology 173, 258-267 (1989).
24. Franchini, G., et al. Nature 328, 539-543 (1987).
25. Balzarini, J., et al. Biochem. biophys. Res. Commun. 145, 269-276 (1987).