Metabolism of the 4-iodo derivative of tamoxifen by isolated rat hepatocytes. Demonstration that the iodine atom reduces metabolic conversion and identification of four metabolites

Biochemical Pharmacology

Volumn 40, Issue 10, 1990, Pages 2277-2283

  McCague, Raymond ^a   Parr, Iris B ^a   Haynes, Benjamin P ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR; IODIDE; TAMOXIFEN DERIVATIVE;

ANIMAL CELL; ARTICLE; DRUG METABOLISM; DRUG STRUCTURE; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

ANIMAL; CELLS, CULTURED; COMPARATIVE STUDY; LIVER; MALE; RATS; RATS, INBRED STRAINS; SPECTRUM ANALYSIS, MASS; SUPPORT, NON-U.S. GOV'T; TAMOXIFEN;

EID: 0025010197     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(90)90723-X     Document Type: Article

References (20)

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2. A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity
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4. Estrogen receptor binding and biological activity of tamoxifen and its metabolites
5. The antitumour activity of tamoxifen and monohydroxytamoxifen. A comparative study in the rat
6. Metabolism of tamoxifen by isolated rat hepatocytes. Identification of the glucuronide of 4-hydroxytamoxifen
7. Metabolism of tamoxifen by isolated rat hepatocytes. Identification of 1-[4-(2-hydroxyethoxy)phenyl]-1-(4-hydroxyphenyl)-2-phenyl-1-butene and the dependence of N-oxidation on oxygen availability
8. Metabolites of tamoxifen in animals and man: identification, pharmacology, and significance
9. Metabolism of 4-hydroxyandrost-4-ene-3,17-dione by rat hepatocytes
10. Hydroxy derivatives of tamoxifen
11. Metabolism of tamoxifen by rat liver microsomes, formation of the N-oxide, a new metabolite
12. Aspects of metabolism of tamoxifen by rat liver microsomes: identification of a new metabolite: E-1-[4-(2-dimethylaminoethoxy)-phenyl-1,2-diphenyl-1-buten-3-ol N-oxide
13. Some chemical and biochemical aspects of liver microsomal metabolism of tamoxifen
14. Estrogenic and antiestrogenic activity of monophenolic analogues of tamoxifen
15. Metabolism of tamoxifen by isolated rat hepatocytes: antioestrogenic activity of tamoxifen N-oxide
16. Determination of tamoxifen and metabolites in patients with advanced breast cancer using gas chromatography-mass spectrometry
17. Evaluation of the antitumour activity of the non-steroidal antioestrogen monohydroxytamoxifen in the DMBA-induced rat mammary carcinoma model
18. Iodine-125-labelled tamoxifen is differentially cytotoxic to cells containing oestrogen receptors
19. 125I]-Iododesethyl tamoxifen aziridine synthesis and covalent labelling of the oestrogen receptor with an iodine-labelled affinity label
20. Fundamental considerations in the design of fluorine-18 labelled progestins and androgens as imaging agents for receptor-positive tumors of the breast and prostate