Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo

European Journal of Pharmacology

Volumn 182, Issue 3, 1990, Pages 591-595

  Thiemermann, Christoph ^a   Vane, John ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

EDRF (endothelium derived relaxing factor); Haemodynamics; L Arginine; Septic shock

Indexed keywords

ARGININE; ENDOTHELIUM DERIVED RELAXING FACTOR; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PHENYLEPHRINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOSYNTHESIS; INTRAVENOUS DRUG ADMINISTRATION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; SEPTIC SHOCK;

ANESTHESIA; ANIMAL; ARGININE; BLOOD PRESSURE; ESCHERICHIA COLI; LIPOPOLYSACCHARIDES; MALE; NITRIC OXIDE; OMEGA-N-METHYLARGININE; PHENYLEPHRINE; RATS; RATS, INBRED STRAINS; SUPPORT, NON-U.S. GOV'T;

EID: 0024993323     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(90)90062-B     Document Type: Article

References (10)

1. G-Methylarginine, an inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea-pig: Does nitric oxide regulate blood pressure in vivo?
2. Role of endothelium in endotoxin blockade of voltage-sensitive Ca2+ channels in smooth muscle cells
3. Mediators produced by the endothelial cell
4. Macrophage cytotoxicity: Role for L-arginine deiminase and imino nitrogen oxidation to nitrite
5. Vascular endothelial cells synthetize nitric oxide from L-arginine
6. Role of endothelium-derived nitric oxide in the regulation of blood pressure
7. Immediate release of a nitric-oxide-like factor from bovine aortic endothelial cells by Escherichia coli lipopolysaccharide
8. Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man
9. Modulation of the vasodepressor actions of acetylcholine, bradykinin, substance P and endothelin in the rat by a specific inhibitor of nitric oxide formation