Preparation of New Nitrogen-Bridged Heterocycles. XXII.1 a New Approach to the Syntheses of Thienoindolizine Derivatives

Chemical and Pharmaceutical Bulletin

Volumn 38, Issue 6, 1990, Pages 1527-1535

  Kakeh, Akikazu ^a   Ito, Suketaka ^a   Naoaki, Yamada ^a   Yamaguchi, Kiminobu ^a  

^a SHINSHU UNIVERSITY   (Japan)

Author keywords

2 a indolizine thieno 2; 2 indolizinethiol thieno 3; 2 (substituted ethyl)thio indolizine; 2 (substituted methyl)thio indolizine; 3 fr indolizine alkylation; deprotection

Indexed keywords

INDOLIZINE DERIVATIVE;

ARTICLE; CHEMICAL STRUCTURE; INFRARED SPECTROPHOTOMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; SYNTHESIS;

EID: 0024992083     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.38.1527     Document Type: Article

References (5)

1. For part XXI of this series, see A. Kakehi, S. Ito, N. Yamada, and K. Yamaguchi, Bull. Chem. Soc. Jpn., 63, 829 (1990).
2. A. Kakehi, S. Ito, S. Matsumoto, and Y. Morimoto, Chem. Lett., 1987, 2043; A. Kakehi, S. Ito, T. Fujii, S. Matsumoto, Y. Morimoto, and M. Shiohara, Bull. Chem. Soc. Jpn., 62, 119 (1989).
3. Some of these thieno[2,3-6\indolizine derivatives were recently found to show anti-HIV (human immuno deficiency virus) activity.
4. A. Kakehi, S. Ito, S. Yonezu, K. Maruta, and K. Yuito, Heterocycles, 23, 33 (1985); A. Kakehi, S. Ito, S. Yonezu, K. Maruta, K. Yuito, M. Shiohara and K. Adachi, Bull. Chem. Soc. Jpn., 60, 1867 (1987); A. Kakehi, S. Ito, N. Kinoshita, and Y. Abaka, Bull. Chem. Soc. Jpn., 61, 2055 (1988).
5. Although these unidentified compounds seem to be intermolecular condensation products of indolizines 4p, q from their elemental and spectral analyses, their structures are still uncertain.