SCOPUS 정보 검색 플랫폼

Volumn 31, Issue 39, 1990, Pages 5587-5590

Preparation of peptidic α-hydroxy phosphonates a new class of transition state analog renin inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHONIC ACID DERIVATIVE; RENIN; RENIN INHIBITOR;

ARTICLE; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL;

EID: 0024987959 PISSN: 00404039 EISSN: None Source Type: Journal
DOI: 10.1016/S0040-4039(00)97903-6 Document Type: Article

Times cited : (260)

References (13)

2
- 0020321280
- Orally active angiotensin converting enzyme (ACE) inhi. bitors have demonstrated that interruption of the renin-angiotensin system is an effecuve way of treating hypertension and congestive heart failure. See
- (1982) Med. Res. Rev. , vol.2 , pp. 1
- Petrillo¹ Ondetti²

3
- 77956837709
- Inhibition of the aspartyl protease renin, the enzyme that precedes ACE in the pathway, would be expected to have a similar effect and has currently been an area of intense research. See
- (1989) Annual Reports in Medicinal Chemistry , vol.24 , pp. 51
- Hamilton¹ Hedges² Taylor³

4
- 0023910548
- New human renin inhibitors containing an unnatural amino acid, norstatine
- 50 = 5 nM, unpublished data). Also see
- (1988) Journal of Medicinal Chemistry , vol.31 , pp. 704
- Iizuka¹ Kamijo² Kubota³ Akahane⁴ Umeyama⁵ Kiso⁶

7
- 0018890715
- 1 proton of cis oxasolidinones normally appears downfieid and has a larger coupling constant compared to the trans oxazolidinunes
- (1980) J. Med. Chem. , vol.23 , pp. 27
- Rich¹ Sun² Ulm³

8
- 37049083457
- Synthesis and reduction of ?-amino ketones derived from leucine
- (1986) Journal of the Chemical Society, Perkin Transactions 1 , pp. 1895
- Defour¹ Jouin² Poncet³ Pantalino⁴ Castro⁵

9
- 84918643496
- 13C NMR is the steric compression effect according to which, sterically perturbed carbon atoms appear at higher field than similar carbons that are not crowded. For example, see

12
- 37049104005
- Protection of histidine side-chains with ?-benzyloxymethyl- or ?-bromobenzyloxymethyl-groups
- The acid 9 was prepared as described. The acid 11 was prepared according to literature procedure, is commercially available.
- (1981) Journal of the Chemical Society, Chemical Communications , vol.12 , pp. 648
- Brown¹ Jones²

13
- 84918648579
- Interestingly, attempted acylation with isopropyl p-nitrophenylcarbonate in the presence of diisopropylethylamine and DMAP (0.1 equiv.) afforded the diacylated compound resulting from both O- & Nacylation as the major product (60%).

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