von Willebrand factor and its disorders: An overview of recent molecular studies

Blood Reviews

Volumn 3, Issue 4, 1989, Pages 251-262

  Tuddenham, E G D ^a  

^a MRC Clinical Research Centre   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DESMOPRESSIN ACETATE; VON WILLEBRAND FACTOR;

HEREDITY; HUMAN; REVIEW; VON WILLEBRAND DISEASE;

ANIMAL; CHROMOSOMES, HUMAN, PAIR 12; DESMOPRESSIN; DNA; FACTOR VIII; GENE EXPRESSION REGULATION; GENES, STRUCTURAL; HEMOSTASIS; HUMAN; PLATELET ADHESIVENESS; PROTEIN PROCESSING, POST-TRANSLATIONAL; SWINE; SWINE DISEASES; VON WILLEBRAND DISEASE; VON WILLEBRAND FACTOR;

EID: 0024951489     PISSN: 0268960X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0268-960X(89)90032-5     Document Type: Article

References (87)

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3. Carbohydrate moiety of von Willebrand factor is not necessary for maintaining multimeric structure and Ristocetin cofactor activity but protects from proteolytic degradation
4. Primary structure of human von Willebrand factor
5. Human von Willebrand factor (vWF): Isolation of complementary DNA (cDNA) clones and chromosomal localization
6. Isolation of a human von Willebrand factor cDNA from the hybrid endothelial cell line EA.hy 926
7. Cloning and characterization of two cDNA's coding for human von Willebrand factor
8. Construction of cDNA coding for human von Willebrand factor using antibody probes for colony screening and mapping of the chromosomal gene
9. cDNA sequences for human von Willebrand factor reveal five types of repeated domains and five possible protein sequence polymorphisms
10. Structure of pre-pro- von Willebrand factor and its expression in heterologous cells
11. von Willebrand's disease antigen II: a new plasma and platelet antigen deficient in severe von Willebrand's disease
12. The effect of DDAVP on plasma levels of von Willebrand antigen II in normal individuals and patients with von Willebrand's disease
13. Correlation between circulating levels of von Willebrand's antigen II and von Willebrand factor: Discrimination between type I and type II von Willebrand's disease
14. Evolution of human von Willebrand factor: cDNA sequence polymorphisms, repeated domains and relationship to von Willebrand antigen II
15. Invertebrate vitellogenin is homologous to human von Willebrand factor
16. The molecular biology of human von Willebrand factor
17. Isolation of a human von Willebrand factor cDNA from the hybrid endothelial cell line EA.hy 926
18. Construction of cDNA coding for human von Willebrand factor using antibody probes for colony screening and mapping of the chromosomal gene
19. Gene deletions correlate with the development of allo antibodies in von Willebrand's disease
20. Carrier detection in severe (type III) von Willebrand disease using two intragenic restriction fragment length polymophisms
21. A polymorphism of the human von Willebrand factor (vWF) gene with Bam HI
22. RFLP for a human von Willebrand factor (vWF) cDNA clone, pv WF 1100
23. A polymorphic Xba I site within the human von Willebrand factor (vWF) gene identified by a vWF cDNA clone
24. Synthesis of antihemophilic factor antigen by cultured endothelial cells
25. Synthesis of factor VIII antigen by cultured guinea-pig megakaryocytes
26. The characterisation and synthesis of antigens related to factor VIII in vascular endothelium
27. Biosynthesis of von Willebrand factor
28. Storage and secretion of von Willebrand factor
29. Molecular and Cellular Biology of von Willebrand factor
30. Expression of variant von Willebrand factor (vWF) cDNA in heterologous cells: requirement of the pro-poly- peptide in vWF multimer formation
31. The propeptide of von Willebrand factor intependently mediates the assembly of von Willebrand multimers
32. Proteolytic cleavage of the precursor of von Willebrand factor (pro-vWF) is not essential for multimer formation
33. von Willebrand factor released from Weibel-Palade bodies binds more avidly to extracellular matrix than that secreted constitutively
34. Synthesis and release of factor VIII by cultured human endothelial cells
35. Biosynthesis of von Willebrand protein by human endothelial cells: Processing steps and their intracellular location
36. von Willebrand protein binds to extracellular matrices independently of collagen
37. 2+ associated with von Willebrand factor release in human endothelial cells exposed to histamines
38. Fibrin induces release of von Willebrand factor from endothelial cells
39. Electron Microscopy of von Willebrand factor
40. Human von Willebrand factor The molecular glue of platelet plugs
41. Structure function relationships of human von Willebrand factor
42. The role of blood flow in platelet adhesion, fibrin deposition and formation of mural thrombi
43. Effect of shear rate on platelet interaction, with subendothelium in citrated and native blood. Shear rate dependent decrease of adhesion in von Willebrand's disease and the Bernard-Soulier Syndrome
44. Decreased platelet adhesion on vessel segments in von Willebrand's disease: A defect in initial platelet attachment
45. DDAVP enhances platelet adherence and platelet aggregate growth on human artery subendothelium
46. Composition of factor VIII related von Willebrand factor proteins prepared from human cryoprecipitate and FVIII concentrate
47. Adhesion of platelet to human artery subendothelium: effect of factor VIII von Willebrand factor of various multimeric composition
48. Evidence that von Willebrand factor and not fibrinogen is involved in glycoprotein IIb-IIIa mediated platelet adhesion and thrombus formation on subendothelium
49. Role of GPIIb/IIIa as well as GPIb in von Willebrand factor-mediated platelet adhesion to collagen
50. Hereditar pseudohemofil
51. Haemophilia
52. Epidemiological investigation of the prevalence of von Willebrand's disease
53. Maladie de Willebrand: etude clinique genetique et biologique
54. Response to infusions of polyelectrolyte fractionated human factor VIII concentrate in human haemophilia A and von Willebrand's disease
55. Stoichiometry of the porcine factor VIII—von Willebrand factor association
56. The effect of thrombin on the complex between factor VIII and von Willebrand factor
57. Serial studies on von Willebrand's disease: variability versus ‘variants’
58. Genetics of classic von Willebrand's disease. I. Phenotypic variation within families
59. Subunit composition of plasma von Willebrand factor. Cleavage is present in normal individuals, increased in IIA and IIB von Willebrand's disease but minimal in variants with aberrant structure (Types IIC, IID and IIE)
60. Gene deletions correlate with the development of alloantibodies in von Willebrand's disease
61. Gene deletion in four patients from the same kindred with severe von Willebrand's disease and anti von Willebrand factor antibodies
62. Molecular basis of human von Willebrand's disease: Analysis of platelet von Willebrand factor mRNA
63. Desmopressin: A nontransfusional form of treatment for congenital and acquired bleeding disorders
64. Multimeric composition of factor VIII/von Willebrand factor following administration of DDAVP: Implications for pathophysiology and therapy of von Willebrand's disease subtypes
65. Response to desmopressin in type IID von Willebrand's disease
66. Unusually large plasma factor VIII: von Willebrand factor multimers in chronic relapsing thrombotic thrombocytopenic purpura
67. The role of von Willebrand factor in thrombotic thrombocytopenic purpura and hemolytic uremic syndrome
68. Resistance to the development of spontaneous atherosclerosis in pigs with von Willebrand's disease
69. Susceptibility to atherosclerosis in aortas and coronary arteries of swine with von Willebrand's disease
70. Arterial thrombosis, atherosclerosis and the factor VIII/von Willebrand factor complex
71. Haemostatic function and cardiovascular death: early results of a prospective study
72. von Willebrand factor multimer patterns in von Willebrand's disease
73. High-resolution analysis of von Willebrand factor multimeric composition defines a new variant of type 1 von Willebrand's disease with aberrant structure but presence of all size multimers (type IC)
74. Heterogeneous abnormalities in the multimeric structure, antigenic properties, and plasma-platelet content of factor VIII/von Willebrand factor in subtypes of classic (type I) and variant (type IIA) von Willebrand's disease
75. Heterogeneity of type I von Willebrand disease: evidence for a subgroup with an abnormal von Willebrand factor
76. The Heterogeneity of type IIA von Willebrand's disease: studies with protease inhibitors
77. Heightened interaction between platelets and factor VIII/von Willebrand factor in a new subtype of von Willebrand's disease
78. Aberrant multimeric structure of von Willebrand factor in a new variant of von Willebrand's disease (type IIC)
79. A new variant of dominant type II von Willebrand's disease with aberrant multimeric pattern of factor VIII-related antigen (type IID)
80. A new variant of type II von Willebrand disease with aberrant multimeric structure of plasma but not platelet von Willebrand factor (type IIF)
81. A variant of Type II von Willebrand disease with an abnormal triplet structure and discordant effects of protease inhibitors on plasma and platelet von Willebrand factor structure
82. High-resolution multimeric analysis identifies a new variant of type II von Willebrand's disease (type IIH) inherited in an autosomal recessive manner
83. A survey of von Willebrand's disease in North London
84. Inherited bleeding disorders
85. Structure and biosynthesis of human von Willebrand factor