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1
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0024358264
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Skin regenerated from cultured epithelial autografts on full-thickness burn wounds from 6 days to 5 years after grafting. A light, electron microscopic and immunohistochemical study
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Of outstanding interest, Skin regeneration was followed with time after grafting cultured keratinocytes onto full-thickness burns. This is the first study of its kind and provides strong evidence that skin can be successfully regenerated using the culture graft technique.
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(1989)
Lab Invest
, vol.60
, pp. 600-612
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-
Compton1
Gill2
Bradford3
Regauer4
Gallico5
O'Connor6
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2
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0023683885
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Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation
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Of interest, This illustrates the information that can be obtained about keratin expression by the combined use of peptide antisera and cRNA probes.
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(1988)
The Journal of Cell Biology
, vol.107
, pp. 427-446
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Stoler1
Kopan2
Duvic3
Fuchs4
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3
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0024504168
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Expression of mutant keratin cDNAs in epithelial cells reveals possible mechanisms for initiation and assembly of intermediate filaments
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Of interest, Regions of the K14 coding sequence necessary for incorporation into keratin filaments are defined.
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(1989)
J Cell Biol
, vol.108
, pp. 1477-1493
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Albers1
Fuchs2
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4
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0000425845
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Tissue-specific and differentiation-specific expression of a human K14 keratin gene in transgenic mice
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Of outstanding interest, The expression of human K14 in transgenic mice is described. Expression is restricted to cells in the basal layer of stratified squamous epithelia, the same cells that express endogenous K14.
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(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 1563-1567
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Vassar1
Rosenberg2
Ross3
Tyner4
Fuchs5
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5
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0024463733
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Enhancer elements directing cell-type-specific expression of cytokeratin genes and changes of the epithelial cytoskeleton by transfections of hybrid cytokeratin genes
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Of outstanding interest, An enhancer upstream of the bovine equivalent of K6 was defined and shown to direct expression of reporter genes in cells that express endogenous K6, but not in cells that lack K6.
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(1989)
EMBO J
, vol.8
, pp. 117-126
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Blessing1
Jorcano2
Franke3
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6
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45449124585
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Morphological and biochemical characterization of the cornified envelopes from human epidermal keratinocytes of different origin
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Of interest, 2 types of cornified envelope were distinguished by morphological criteria. There is evidence that one may be the precursor of the other, and that the more mature form is lacking in psoriatric epidermis and keratinocyte cultures.
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(1988)
J Invest Dermatol
, vol.91
, pp. 11-15
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Michel1
Schmidt2
Shroot3
Reichert4
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7
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0023792758
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Remodeling of the involucrin gene during primate evolution
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Of interest, The involucrin genes of lemur and human were compared. The modern segment of repeats in the human must have been formed after the divergence of the higher primates from the prosimians.
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(1988)
Cell
, vol.54
, pp. 491-496
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Tseng1
Green2
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8
-
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0007049387
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Divergent evolution of part of the involucrin gene in the hominoids: unique intragenic duplications in the gorilla and human
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Of outstanding interest, The modern segment of the involucrin gene can be subdivided into early, middle and late regions. The modern segment is evolving rapidly and its repeat structure makes it a very useful tool for studies of molecular evolution.
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(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 1283-1286
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Teumer1
Green2
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9
-
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0024341641
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Involucrin in the epidermal cells of subprimates
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Of interest, Rabbit and dog involucrin were identified using antisera raised against peptides within the ancestral segment of human involucrin.
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(1989)
J Invest Dermatol
, vol.92
, pp. 721-724
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Simon1
Green2
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10
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0024224559
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The glutamine residues reactive in transglutaminase-catalyzed cross-linking of involucrin
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Of interest, One glutamine residue was identified within involucrin, which is the preferred reactive site of the epidermal transglutaminase. Further sites become reactive when involucrin undergoes proteolysis.
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(1988)
J Biol Chem
, vol.263
, pp. 18093-18098
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Simon1
Green2
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12
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0024237452
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Characterization of an epidermal phosphatase specific for filaggrin phosphorylated by casein kinase II
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Of interest, A phosphatase that may act on profilaggrin during processing to form filaggrin is described.
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(1988)
J Invest Dermatol
, vol.91
, pp. 553-559
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Haugen-Scofield1
Resing2
Dale3
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13
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0024599909
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Identification of proteolytic cleavage sites in the conversion of profilaggrin to filaggrin in mammalian epidermis
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Of interest, A model for proteolytic processing of profilaggrin involving 3 distinct stages is proposed. Partial purification of enzymic activity corresponding to the first stage is described.
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(1989)
J Biol Chem
, vol.264
, pp. 1837-1845
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Resing1
Walsh2
Haugen-Scofield3
Dale4
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14
-
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0024543799
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Increased cholesterol sulfate and cholesterol sulfotransferase activity in relation to the multi-step process of differentiation in human epidermal keratinocytes
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Of interest, Increased cholesterol sulphate is shown to be a marker of terminal differentiation in culture. Although cholesterol sulphate accumulation is inhibited by retinoids, the commitment to terminal differentiation is retinoid insensitive.
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(1989)
J Invest Dermatol
, vol.92
, pp. 203-209
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Jetten1
George2
Nervi3
Boone4
Rearick5
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15
-
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0024110741
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The function of multiple extracellular matrix receptors in mediating cell adhesion to extracellular matrix: preparation of monoclonal antibodies to the fibronectin receptor that specifically inhibit cell adhesion to fibronectin and react with platelet glycoproteins Ic-IIa
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Of interest, Several antibodies to integrins which block integrin-mediated cell adhesion were described and their distribution in fetal skin, documented.
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(1988)
J Cell Biol
, vol.107
, pp. 1881-1891
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Wayner1
Carter2
Piotrowicz3
Kunicki4
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16
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0024430105
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4) from human epithelial cells suggests a fourth family of integrin adhesion receptors
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Of interest, A new class of integrins which may be specifically expressed in epithelia is described.
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(1989)
EMBO J
, vol.8
, pp. 673-680
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Kajiji1
Tamura2
Quaranta3
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17
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0024375514
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Retinoic acid improves epidermal morphogenesis
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Of interest, The effect of different concentrations of retinoic acid on epidermal keratinocytes grown on a dermal equivalent is described. In the presence of excess retinoic acid suprabasal expression of the fibronectin receptor is observed.
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(1989)
Dev Biol
, vol.133
, pp. 322-335
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Asselineau1
Bernard2
Bailly3
Darmon4
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19
-
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0024324070
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Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth
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Of outstanding interest, A new member of the fibroblast growth factor family is described which is made by mesenchymal cells and stimulates proliferation of epithelial cells, including keratinocytes.
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(1989)
Science
, vol.245
, pp. 752-755
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Finch1
Rubin2
Miki3
Ron4
Aaronson5
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20
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0023691805
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Human epithelial cells induce human melanocyte growth in vitro but only skin keratinocytes regulate its proper differentiation in the absence of dermis
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Of outstanding interest, Keratinocytes were shown to stimulate melanocyte growth by a process that requires cell-cell contact. Epidermal, but not oral, keratinocytes directed the correct spatial distribution of melanocytes in culture.
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(1988)
J Cell Biol
, vol.107
, pp. 1919-1926
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De Luca1
D'Anna2
Bondanza3
Franzi4
Cancedda5
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21
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2642666080
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Cell shape controls terminal differentiation of human epidermal keratinocytes
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Of interest, Restricted substratum contact can act as a signal for terminal differentiation. Inhibition of proliferation is not a sufficient signal for terminal differentiation.
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(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 5576-5580
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Watt1
Jordan2
O'Neill3
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22
-
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0024395197
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Fibronectin inhibits the terminal differentiation of human keratinocytes
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Of outstanding interest, Fibronectin inhibits suspension-induced terminal differentiation of keratinocytes, suggesting that the level of occupancy of extracellular matrix receptors may be a signal for terminal differentiation. Commitment to terminal differentiation appears to precede involucrin expression by several hours.
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(1989)
Nature
, vol.340
, pp. 307-309
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Adams1
Watt2
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23
-
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0024506912
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Intracellular calcium alterations in response to increased external calcium in normal and neoplastic keratinocytes
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Of interest, Digital imaging microscopy has been used to measure changes in the level of intracellular calcium ions in response to changes in the extracellular calcium ion concentration.
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(1989)
Carcinogenesis
, vol.10
, pp. 777-780
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-
Hennings1
Kruszewski2
Yuspa3
Tucker4
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24
-
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0024381154
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Cloning of murine α and β retinoic acid receptors and a novel receptor γ predominantly expressed in skin
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Of outstanding interest, A third class of nuclear retinoic acid receptor was isolated which is predominantly expressed in skin and which may therefore play a role in mediating the effects of vitamin A on keratinocyte terminal differentiation.
-
(1989)
Nature
, vol.339
, pp. 714-717
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Zelent1
Krust2
Petkovich3
Kastner4
Chambon5
-
25
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0023724829
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An unusual strain of human keratinocytes which do not stratify or undergo terminal differentiation in culture
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Of interest, A strain of cells, derived from epidermal keratinocytes, which do not stratify or undergo terminal differentiation is described.
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(1988)
J Cell Biol
, vol.107
, pp. 1927-1938
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-
Adams1
Watt2
-
26
-
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0024409168
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Restoration of growth potential in paraclones of human keratinocytes by a viral oncogene
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Of outstanding interest, Keratinocytes which would normally undergo terminal differentiation after a few rounds of division were ‘rescued’ by infection with E1A and continued to proliferate. This suggests that the targets for neoplastic transformation need not necessarily be stem cells.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 4102-4106
-
-
Barrandon1
Morgan2
Mulligan3
Green4
-
27
-
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0024537140
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Tissue site-specific enhancer function of the upstream regulatory region of human papillomavirus type 11 in cultured keratinocytes
-
Of interest, The upstream regulatory region of HPV 11 is a more efficient enhancer of reporter genes in laryngeal or genital keratinocytes (the normal host cells) than in epidermal keratinocytes.
-
(1989)
J Virol
, vol.63
, pp. 957-960
-
-
Steinberg1
Auborn2
Brandsma3
Taichman4
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