High density culture of Coptis japonica cells increases berberine production

Journal of Chemical Technology & Biotechnology

Volumn 46, Issue 1, 1989, Pages 61-69

  Matsubara, Koichi ^a   Kitani, Shigekazu ^a   Yoshioka, Toshihiro ^a   Morimoto, Teijiro ^a   Fujita, Yasuhiro ^a   Yamada, Yasuyuki ^b  

^a MITSUI CHEMICALS INC   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

aeration; agitation; berberine; cell culture; Coptis japonica; fed batch culture; high cell density

Indexed keywords

METABOLITE;

BERBERINE PRODUCTION; COPTIS JAPONICA CELLS; FED-BATCH CULTURE; HIGH CELL DENSITY;

CELL CULTURE;

BACTERIA (MICROORGANISMS); COPTIS JAPONICA; JAPONICA;

EID: 0024874925     PISSN: 02682575     EISSN: 10974660     Source Type: Journal    
DOI: 10.1002/jctb.280460107     Document Type: Article

References (11)

1. Berberine production by cultured Coptis japonica cells in a one‐stage culture using medium with a high copper concentration
2. High berberine‐producing cultures of Coptis japonica cells
3. Production of useful compounds
4. Enhancement of berberine production in suspension cultures of Coptis japonica by gibberellic acid treatment
5. The effective production of shikonin by cultures with an increased cell population
6. Technological problems in cultivation of plant cells at high density
7. Production of berberine in cultured cells of Coptis japonica
8. Colorimetrical analysis of ammonium.
9. Colorimetric method for determination of sugars and related substances
10. Growth and product formation in large scale and continuous culture systems.
11. Oxygen transfer in broths of plant cells at high density