Thioethers, mutagens, and D‐glucaric acid in urine of operating room personnel exposed to anesthetics

Teratogenesis, Carcinogenesis, and Mutagenesis

Volumn 9, Issue 6, 1989, Pages 359-368

  Pasquini, R ^a   Monarca, S ^b   Sforzolini, G Scassellati ^a   Bauleo, F A ^c   Angeli, G ^a   Cerami, F ^d  

^a UNIVERSITY OF PERUGIA   (Italy)

^b UNIVERSITY OF BRESCIA   (Italy)

^c Local Health Unit 3 Umbria   (Italy)

^d General Hospital   (Italy)

Author keywords

biological monitoring; enflurane; environmental monitoring; nitrous oxide; occupational exposure; urine D glucaric acid; urine mutagenicity; urine thioethers

Indexed keywords

ANESTHETIC AGENT; ENFLURANE; MUTAGENIC AGENT; NITROUS OXIDE; SACCHARIC ACID; SUGAR ACID; SULFIDE;

ADULT; AIR POLLUTANT; ANESTHESIOLOGY; ARTICLE; COMPARATIVE STUDY; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; FEMALE; HOSPITAL PERSONNEL; HUMAN; MALE; OPERATING ROOM; OPERATING ROOM PERSONNEL; SURGERY; URINE; NORMAL HUMAN;

ADULT; AIR POLLUTANTS, OCCUPATIONAL; ANESTHESIOLOGY; ANESTHETICS; COMPARATIVE STUDY; ENFLURANE; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; FEMALE; GLUCARIC ACID; HUMAN; MALE; MUTAGENS; NITROUS OXIDE; OPERATING ROOM NURSING; OPERATING ROOMS; PERSONNEL, HOSPITAL; SUGAR ACIDS; SULFIDES; SUPPORT, NON-U.S. GOV'T; SURGERY;

EID: 0024854980     PISSN: 02703211     EISSN: 15206866     Source Type: Journal    
DOI: 10.1002/tcm.1770090604     Document Type: Article

References (64)

1. A prospective survey of anesthesiologist mortality, 1967–1971
2. Health experiences of operating room personnel
3. Occupational hazards to the operating room and recovery room personnel
4. Anesthetic gases as an occupational hazard: A review
5. Trace concentrations of anesthetic gases: A critical review of their disease potential
6. Mortality experience among anesthesiologists, 1954–1976
7. Occupational hazards of anesthesia
8. Mutagenicity of volatile anesthetics: Halothane
9. Mutagenicity of inhalation anesthetics: Nitrous oxide, cyclopropane, trichloroethylene and divynil ether
10. Mutagenic effects of inhalation anesthetics
11. Lack of mutagenic effects of halothane in mammals in vivo
12. Mutagenicity studies with volatile metabolites of halothane
13. Mutagenicity studies with halothane in Drosophila melanogaster
14. Genotoxic and mutagenic assays of halothane metabolites in Bacillus subtilis and Salmonella typhimurium
15. Detection of mutagenic activity in the urines of anesthesiologists: A preliminary report
16. Lack of mutagens in urines of operating room personnel
17. Chromosome aberrations and sister chromatid exchanges in occupationally exposed workers
18. Sister chromatid exchanges in peripheral lymphocytes in operating room personnel
19. Occupational exposure to halothane results in enzyme induction in anesthetics
20. Hepatic microsomal enzyme induction by inhalation anesthetics
21. Nonspecific stimulation of drug metabolizing enzymes by inhalation anesthetic agents
22. Increased hepatic microsomal enzyme activity after surgery under halothane or spinal anesthesia
23. Microsomal enzyme induction after halothane anaesthesia
24. Effect of surgery under general anaesthesia on antipyrine metabolism
25. Urine mutagenicity of steel workers exposed to coke oven emissions
26. Exposure to carcinogenic chemicals and smoking increases the urinary excretion of mutagens in humans
27. Detection of occupational and environmental exposures by bacterial mutagenesis assays of human body fluids
28. Mutagenicity in urine of workers in rubber industry
29. Mutagenicity in urine of nurses handling cytostatic drugs
30. Detection of occupational exposure to genotoxic agents with a urinary mutagen assay
31. Urinary mutagenicity in occupational exposure to mineral oils and iron oxide particles
32. Mutagenicity studies with urine concentrates from coke plant workers
33. Mutagens in urine of carbon electrode workers
34. Mutagenicity studies and d‐glucaric acid determination in urine of workers exposed to mineral oils
35. Urinary excretion of mutagens, thioethers and d‐glucaric acid in workers exposed to bitumen fumes
36. Application of urine mutagenicity to monitor coal liquefaction workers
37. Urinary mutagens in municipal sewage workers and water treatment workers
38. Urinary mercapturic acid in chemical workers and in control subjects
39. Urinary excretion of thioethers among low‐tar and medium‐tar cigarette smokers
40. Excretion of thioethers in urine after exposure to electrophilic chemicals
41. Correlation of urinary thioethers with chemical exposure in a rubber plant
42. Increased urinary excretion of thioether in new rubber workers
43. Thioethers in urine during occupational exposure to tetrachloroethylene
44. Urinary thioethers in low tar cigarette smokers
45. A pilot study of urinary thioethers as biological indicators of the urban contamination
46. Urinary thioethers of employees of a chemical plant
47. Enhanced excretion of thioethers in urine of operators of chemical waste incinerators
48. Detection of human exposure to electrophilic compounds by assay of thioether detoxification products in urine
49. Determination of thio compounds in urine of workers exposed to carbon disulfide
50. Low‐pH method for the enzymatic assay of d‐glucaric acid in urine
51. Influence of sex, age and smoking habits on the urinary excretion of d‐glucaric acid
52. Urinary d‐glucaric acid excretion as a test for hepatic enzyme induction in man
53. Urinary d‐glucaric acid excretion and total liver content of cytochrome P‐450 in guinea pigs: Relationship during enzyme induction and following inhibition of protein synthesis
54. Improved determination of d‐glucaric acid in urine
55. The interaction of chemical compounds with the functional state of the liver. Estimation of changes in d‐glucaric acid synthesis as a method for diagnosing exposure to xenobiotics
56. Application of the Salmonella mutagenicity assay and determination of polycyclic aromatic hydrocarbons in workplaces exposed to petroleum pitch and petroleum coke
57. Mutagenic/carcinogenic hazards in a cold‐rolling steel plant exposed to mineral oils: Environmental monitoring phase
58. Environmental monitoring of mutagenic/carcinogenic hazards during road paving operations with bitumens
59. Concentration of mutagens from urine by adsorption with the non‐polar resin XAD‐2: Cigarette smokers have mutagenic urine
60. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian‐microsome mutagenicity test
61. Revised methods for the Salmonella mutagenicity test