Clonidine-Displacing Substance is Present in Peripheral Tissues of the Rat

American Journal of Hypertension

Volumn 2, Issue 12, 1989, Pages 917-919

  Hensley, Martee L ^a   Meeley, Mary P ^a   McCauley, Phillip M ^a   Ernsberger, Paul ^a   Reis, Donald J ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Clonidine displacing substance; Clonidinespecific antibodies; Imidazole receptors; Peripheral tissues; Radioimmunoassay

Indexed keywords

ANTIBODY; CLONIDINE; RADIOISOTOPE;

ADRENAL GLAND; ANIMAL CELL; ARTICLE; BINDING SITE; DRUG TISSUE BINDING; LUNG; NONHUMAN; RADIOIMMUNOASSAY; RAT; STOMACH; THROMBOCYTE; VAS DEFERENS;

ANIMAL; ANTIBODIES; CLONIDINE; MALE; RADIOIMMUNOASSAY; RATS; TISSUE DISTRIBUTION;

EID: 0024846340     PISSN: 08957061     EISSN: 19417225     Source Type: Journal    
DOI: 10.1093/ajh/2.12.917     Document Type: Article

References (18)

1. 2-adrenoceptors in the ventrolateral medulla. Eur J Pharmacol 1987; 134: 1-13.
2. Bousquet P, Schwartz J Adrenergic drugs: pharmacological tools for the study of the central vasomotor control. Biochem Pharmacol 1983; 32: 1459-1465.
3. 2-adrenergic clonidine action. Fed Proc 1987; 46: 1460.
4. 2-adrenergic receptors in the rostral ventrolateral medulla. J Hypertens (in press).
5. Atlas D, Burstein Y: Isolation and partial purification of a clonidine-displacing endogenous brain substance. Eur J Biochem 1984; 144: 287-293.
6. Meeley MP, Ernsberger PR, Granata AR, Reis DJ: An endogenous clonidine-displacing substance from bovine brain: receptor binding and hypotensive actions in the ventrolateral medulla. Life Sci 1986; 38: 1119-1126.
7. Ernsberger P, Meeley MP, Reis DJ: An endogenous substance with clonidine-like properties: selective binding to imidazole sites in the ventrolateral medulla. Brain Res 1988; 441: 309-318.
8. Bousquet P, Feldman J, Atlas D: An endogenous, noncatecholamine clonidine antagonist increases mean arterial blood pressure. Eur J Pharmacol 1986; 124: 167-170.
9. Diamant S, Atlas D: An endogenous brain substance, CDS (clonidine-displacing substance), inhibits the twitch response of rat vas deferens. Biochem Biophys Res Commun 1986; 134: 184-190.
10. 2-adrenoceptors of human platelets. Eur J Pharmacol 1987; 144: 247-255.
11. Felsen D, Ernsberger P, Meeley MP, Reis DJ: Clonidinedisplacing substance is biologically active on smooth muscle. Eur J Pharmacol 1987; 142: 453-455.
12. Meeley MP, Towle AC, Ernsberger P, Reis DJ: A specific antiserum recognizes clonidine-displacing substance: implications for the structure of the brain's own clonidine. Neurosci Lett 1988; 84: 84-90.
13. Meeley MP, Towle AC, Ernsberger P, et al: Clonidinespecific antisera recognize an endogenous clonidine-displacing substance in brain. Hypertension 1989; in press.
14. Ernsberger P, Feinland G, Meeley MP, Reis DJ: Characterization and visualization of clonidine-sensitive imidazole sites in rat kidney which recognize clonidine-displacing substance. Am J Hypertens (in press).
15. Ernsberger P, Felsen D, Meeley MP, Reis DJ: An endogenous clonidine-displacing substance elicits a specific contractile response in rat gastric fundus. Eur J Pharmacol (submitted).
16. Krothapalli RK, Suki WN: Functional characterization of the alpha adrenergic receptor modulating the hydroosmotic effect of vasopressin on the rabbit cortical collecting tubule. J Clin Invest 1984; 73: 740-749.
17. +antiport activity in the rabbit renal proximal tubule. J Clin Invest 1987; 80: 1755-1762.
18. Biollaz J, Roch-Ramel F, Kirchertz EJ, et al: The renal effects of clonidine in unanesthetized rats. Eur J Pharmacol 1979; 58: 407-418.