Immunization of cotton rats with the fusion (F) and large (G) glycoproteins of respiratory syncytial virus (RSV) protects against RSV challenge without potentiating RSV disease

Vaccine

Volumn 7, Issue 6, 1989, Pages 533-540

  Murphy, Brian R ^a   Sotnikov, Alex ^b   Paradiso, Peter R ^c   Hildreth, Stephen W ^b   Jenson, A Bennett ^b   Baggs, Raymond B ^d   Lawrence, Lisa ^a   Zubak, Joseph J ^a   Chanock, Robert M ^a   Beeler, Judy A ^e   Prince, Gregory A ^e  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

^c PFIZER INC   (United States)

^d UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^e JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

glycoprotein; Respiratory syncytial virus; vaccine

Indexed keywords

VIRUS ANTIBODY; VIRUS GLYCOPROTEIN; VIRUS VACCINE;

ANIMAL EXPERIMENT; ARTICLE; IMMUNIZATION; INTRAMUSCULAR DRUG ADMINISTRATION; NONHUMAN; RAT; RESPIRATORY SYNCYTIAL PNEUMOVIRUS;

ANIMAL; ANTIBODIES, MONOCLONAL; ANTIBODIES, VIRAL; ANTIGENS, VIRAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNIZATION; MICROTINAE; RATS; RESPIRATORY SYNCYTIAL VIRUSES; RESPIROVIRUS INFECTIONS; T-LYMPHOCYTES, CYTOTOXIC; VACCINES, INACTIVATED; VIRAL FUSION PROTEINS; VIRAL VACCINES;

EID: 0024826889     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0264-410X(89)90278-8     Document Type: Article

References (19)

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2. Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine
3. Enhancement of respiratory syncytial virus pulmonary pathology in cotton rats against viral infection
4. Immunization with glycoprotein subunits of respiratory syncytial virus to protect cotton rats against viral infection
5. Current approaches to the development of vaccines effective against parainfluenza and respiratory syncytial viruses
6. The pathogenesis of respiratory syncytial virus infection in cotton rats
7. Measurement of protein using bicinchoinic acid
8. Neutralization epitopes of the F glycoprotein of respiratory syncytial virus: effect of mutation upon fusion function
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14. Pharyngeal aspiration in normal adults and patients with depressed consciousness
15. The purification of four respiratory syncytial virus proteins and their evaluation as protective agents against experimental infection in BALB/c mice
16. Quantitative aspects of passive immunity to respiratory syncytial virus infection in infant cotton rats
17. Cytotoxic T-cell specificity for respiratory syncytial virus proteins fusion protein is an important target antigen
18. The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides
19. HLA-restricted virus specific cytotoxic T-lymphocytes responses to live and inactivated influenza vaccines