Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun

Cell

Volumn 59, Issue 6, 1989, Pages 979-986

  Chiu, Robert ^a   Angel, Peter ^a   Karin, Michael ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ONCOPROTEIN;

ARTICLE; CELL CULTURE; HUMAN; HUMAN CELL; ONCOGENE; ONCOGENE C JUN; PRIORITY JOURNAL; PROTEIN DNA BINDING;

ANIMAL; CELLS, CULTURED; DNA-BINDING PROTEINS; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HOMEOSTASIS; HUMAN; KINETICS; MICE; ONCOGENES; PLASMIDS; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-JUN; PROTO-ONCOGENES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 0024815627     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(89)90754-X     Document Type: Article

References (45)

1. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor
2. Oncogene jun encodes a sequence-specific trans-activator similar to AP-1
3. The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1
4. Jun and v-Jun contain multiple regions that participate in transcription activation in an interdependent manner
5. Growth factors and membrane depolarization activate distinct programs of early response gene expression: dissociation of fos and jun induction
6. A pituitary-specific trans-acting factor can stimulate transcription from the growth hormone promoter in extracts of nonexpressing cells
7. The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein
8. Human proto-oncogene c-jun encodes a DNA binding protein with structural functional properties of transcription factor AP-1
9. Transcriptional regulation by the AP-1 family of enhancer-binding proteins: a nuclear target for signal transduction
10. Prolonged activation of jun and collagenase genes by tumour necrosis factor-α
11. Activation of the c-fos gene by UV and phorbol esters: different signal transduction pathways converge to the same enhancer element
12. The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes
13. Protein encoded by v-erb-A functions as a thyroid-hormone receptor antagonist
14. Cooperativity and hierarchical levels of functional organization in the SV40 enhancer
15. Negative effect of the transcriptional activator GAL4
16. The c-fos serum response element responds to protein kinases C-dependent and -independent signals, but not to cyclic AMP
17. Cooperative DNA binding of the yeast transcriptional activator GAL4
18. Dual regulatory role for thyroid-hormone receptors allows control of retinoic-acid receptor activity
19. Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene
20. A family of immunologically related transcription factors that includes ATF and AP-1
21. Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes
22. The SV40 enhancer is composed of multiple functional elements that can compensate for one another
23. Characterization of junD: a new member of the jun proto-oncogene family
24. Metallothionein gene expression is regulated by serum factors and activators of protein kinase C
25. A enhancer activity
26. Induction of a factor that binds to the polyoma virus A enhancer on differentiation of embryonal carcinoma cells
27. Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40
28. Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements
29. Tissue specific expression of the human growth hormone gene is conferred in part by the binding of a specific trans-acting factor
30. Interleukin 1 costimulatory activity on the interleukin 2 promoter via AP-1
31. DNA binding activities of three murine Jun proteins: stimulation by Fos
32. The SV-40 enhancer contains two distinct levels of organization
33. How eukaryotic transcriptional activators work
34. Fos-associated protein (p39) is the product of the jun proto-oncogene
35. Induction of protooncogene c-fos by serum growth factors
36. A gene activated by growth factors is related to the oncogene v-jun
37. Jun-D: a third member of the jun gene family
38. Repression of transcription mediated at a thyroid hormone response element by the v-erb-A oncogene product
39. fos-associated cellular p39 is related to nuclear transcription factor AP-1
40. Glucocorticoid- and progesterone-specific effects are determined by differential expression of the respective hormone receptors
41. The JUN oncoprotein, a vertebrate transcription factor, activates transcription in yeast
42. Cooperative binding of steroid hormone receptors contributes to transcriptional synergism at target enhancer elements
43. Jun: oncogene and transcription factor
44. The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity