The dependence on intracellular ATP concentration of ATP-sensitive K-channels and of Na,K-ATPase in intact HIT-T15β-cells

FEBS Letters

Volumn 257, Issue 2, 1989, Pages 361-364

  Niki, Ichiro ^a   Ashcroft, Frances M ^b   Ashcroft, Stephen J H ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

ATP sensitive K channel; HIT T15 cells, Pancreatic cells); Insulin secretion; Na,K ATPase; Potassium channel

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATE; INSULIN; POTASSIUM CHANNEL; RADIOISOTOPE; CALCIUM; DEOXYGLUCOSE; GLIBENCLAMIDE; OLIGOMYCIN; OUABAIN; RUBIDIUM 86;

ARTICLE; CELL CULTURE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; ADENOSINE TRIPHOSPHATE CELL LEVEL; BIOLOGICAL MODEL; NONHUMAN; PANCREAS; POTASSIUM CHANNEL;

ADENOSINE TRIPHOSPHATE; CALCIUM; CELL COMPARTMENTATION; CELL LINE; CYTOPLASM; DEOXYGLUCOSE; INSULIN; ISLETS OF LANGERHANS; NA(+)-K(+)-EXCHANGING ATPASE; OLIGOMYCINS; POTASSIUM CHANNELS; SUPPORT, NON-U.S. GOV'T;

EID: 0024805839     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-5793(89)81572-8     Document Type: Article

References (25)

1. Inhibition of ATP-regulated K+ channels precedes depolarization-induced increase in cytoplasmic free Ca2+ concentration in pancreatic beta-cells.
2. Concentration-dependent effects of tolbutamide, meglitinide, glipizide, glibenclamide and diazoxide on ATP-regulated K+ currents in pancreatic B-cells
3. Glucose dependent K+-channels in pancreatic?-cells are regulated by intracellular ATP
4. The glucose sensor in HIT cells is the glucose transporter