jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun

Cell

Volumn 59, Issue 6, 1989, Pages 987-997

  Schütte, Jochen ^a   Viallet, Jean ^a   Nau, Marion ^a   Segal, Shoshana ^a   Fedorko, Joseph ^a   Minna, John ^a  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHORBOL ESTER;

ANIMAL CELL; ARTICLE; CELL TRANSFORMATION; EMBRYO CELL; HUMAN; NONHUMAN; ONCOGENE; ONCOGENE C FOS; ONCOGENE C JUN; PRIORITY JOURNAL; RAT;

AMINO ACID SEQUENCE; ANIMAL; BASE SEQUENCE; CELL TRANSFORMATION, NEOPLASTIC; DNA PROBES; DNA-BINDING PROTEINS; GENES, REGULATOR; HUMAN; MOLECULAR SEQUENCE DATA; ONCOGENES; PROTEIN-TYROSINE KINASE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; PROTO-ONCOGENES; RATS; RESTRICTION MAPPING; RNA PROBES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSFECTION;

ANIMALIA;

EID: 0024800229     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(89)90755-1     Document Type: Article

References (60)

1. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor
2. Oncogene jun encodes a sequence-specific transactivator similar to AP-1
3. The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1
4. Growth factors and membrane depolarization activate distinct programs of early response gene expression: dissociation of fos and jun induction
5. L-myc cooperates with ras to transform primary rat embryo fibroblasts
6. Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1
7. Establishment and identification of small cell lung cancer cell lines having classic and variant features
8. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
9. The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes
10. fra-1: a serum-inducible, cellular immediate-early gene that encodes a Fos-related antigen
11. The product of a fos-related gene, fra-1, binds cooperatively to the AP-1 site with Jun: transcription factor AP-1 is comprised of multiple protein complexes
12. Fos and Jun: the AP-1 connection
13. FBJ murine osteosarcoma virus: identification and molecular cloning of biologically active proviral DNA
14. Expression of a transfected human c-myc oncogene inhibits differentiation of a mouse erythroleukemia cell line
15. Specific growth response of ras-transformed embryo fibroblasts to tumour promoters
16. The Fos complex and Fos-related antigens recognize sequence elements that contain AP-1 binding sites
17. Parallel association of Fos and Jun leucine zippers juxtaposes DNA binding domains
18. c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities
19. Structure and chromosomal localization of the functional intronless human JUN protooncogene
20. Characterization of junD: a new member of the jun proto-oncogene family
21. Oncogene-induced transformation of C3H 10T1/2 cells is enhanced by tumor promoters
22. A Harvey-ras responsive transcription element is also responsive to a tumour-promoter and to serum
23. Structure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processing
24. The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins
25. Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements
26. Activation of the transforming potential of the human fos proto-oncogene requires message stabilization and results in increased amounts of partially modified fos protein
27. Reverse transcription of retroviral genomes: mutation in the terminal repeat sequences
28. Transactivation of gene expression by fos protein: involvement of a binding site for the transcription factor AP-1
29. Avian sarcoma virus 17 carries the jun oncogene
30. c-fos protein can induce cellular transformation: a novel mechanism of activation of a cellular oncogene
31. Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins
32. DNA binding activities of three murine Jun proteins: stimulation by Fos
33. Preferential heterodimer formation by isolated leucine zippers from Fos and Jun
34. Enhanced jun gene expression is an early genomic response to transforming growth factor β stimulation
35. Two different factors bind to the α-domain of the polyoma virus enhancer, one of which also interacts with the SV40 and c-fos enhancers
36. Fos-associated protein p39 is the product of the jun proto-oncogene
37. A common DNA binding site for Fos protein complexes and transcription factor AP-1
38. Fos and Jun bind cooperatively to the AP-1 site: reconsitution in vitro
39. Structure of the human immunoglobulin μ locus: characterization of embryonic and rearranged J and D genes
40. Removal of an mRNA destabilizing element correlates with the increased oncogenicity of proto-oncogene fos
41. A gene activated by growth factors is related to the oncogene v-jun
42. Jun-D: a third member of the Jun gene family
43. Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts
44. DNA sequencing with chain-terminating inhibitors
45. fos-associated cellular p39 is related to nuclear transcription factor AP-1
46. Transcriptional autoregulation of the proto-oncogene fos
47. Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters
48. The leucine repeat motif in Fos protein mediates complex formation with Jun/AP-1 and is required for transformation
49. Deregulated expression of human c-jun transforms primary rat embryo cells in cooperation with an activated c-Ha-ras gene and transforms Rat-1a cells as a single gene
50. Differentiation as a requirement for SV40 gene expression in F-9 embryonal carcinoma cells
51. Isolation of a transforming sequence from a human bladder carcinoma cell line
52. Neoplastic transformation by the human gene N-myc
53. The induction of differentiation in teratocarcinoma stem cells by retinoic acid
54. The DNA-binding domains of the jun oncoprotein and the yeast GCN4 transcriptional activator proteins are functionally homologous
55. Normal rat cell lines deficient in nuclear thymidine kinase
56. Oncogene and transcription factor
57. Homology between the DNA-binding domain of the GCN4 regulatory protein of yeast and the carboxyl-terminal region of a protein coded for by the oncogene jun
58. Transforming but not immortalizing oncogenes activate the transcription factor PEA1
59. The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity