Sequence requirements for cytochrome P-450IIB1 catalytic activity. Alteration of the stereospecificity and regioselectivity of steroid hydroxylation by a simultaneous change of two hydrophobic amino acid residues to phenylalanine

Journal of Biological Chemistry

Volumn 264, Issue 35, 1989, Pages 21327-21333

  Aoyama, T ^a   Korzekwa, K ^a   Nagata, K ^a   Adesnik, M ^a   Reiss, A ^a   Lapenson, D P ^a   Gillette, J ^a   Gelboin, H V ^a   Waxman, D J ^a   Gonzalez, F J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450;

ANIMAL CELL; ARTICLE; NONHUMAN; PRIORITY JOURNAL; RAT; STEREOSPECIFICITY; STEROID HYDROXYLATION; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMAL; BASE SEQUENCE; BINDING SITES; CHIMERA; CLONING, MOLECULAR; GENETIC VECTORS; ISOLEUCINE; LEUCINE; LIVER; MOLECULAR SEQUENCE DATA; MUTATION; PHENYLALANINE; POLY A; RATS; RATS, INBRED STRAINS; RNA, MESSENGER; STEROID 11-BETA-HYDROXYLASE; STEROID HYDROXYLASES; SUPPORT, U.S. GOV'T, P.H.S.; TESTOSTERONE; VACCINIA VIRUS;

ANIMALIA; VACCINIA; VACCINIA VIRUS;

EID: 0024797902     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (0)