Junctional sequences of T cell receptor γδ genes: Implications for γδ T cell lineages and for a novel intermediate of V-(D)-J joining

Cell

Volumn 59, Issue 5, 1989, Pages 859-870

  Lafaille, Juan J ^a   DeCloux, Amy ^a   Bonneville, Marc ^a   Takagaki, Yohtaroh ^a   Tonegawa, Susumu ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANTIGEN DIVERSITY; ANTIGEN RECOGNITION; ARTICLE; DNA SEQUENCE; GENE EXPRESSION; GENE STRUCTURE; GENETIC ENGINEERING; MOUSE; NONHUMAN; PRIORITY JOURNAL;

AGING; ANIMAL; ANIMALS, NEWBORN; BASE SEQUENCE; CODON; FETUS; GENE AMPLIFICATION; GENES, IMMUNOGLOBULIN; GENES, STRUCTURAL; IMMUNOGLOBULIN JOINING REGION; MACROMOLECULAR SYSTEMS; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; RECEPTORS, ANTIGEN, T-CELL; RECOMBINATION, GENETIC; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; T-LYMPHOCYTES; THYMUS GLAND;

ANIMALIA;

EID: 0024791338     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(89)90609-0     Document Type: Article

References (71)

1. Tumor-specific antigen of murine T lymphoma defined with monoclonal antibody
2. H fusions
3. Multiple immunoglobulin heavy-chain gene transcripts in Abelson Murine Leukemia virus-transformed lymphoid cell lines
4. + dendritic epidermal cells
5. A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes
6. β gene segment
7. T-cell receptor beta-chain expression: dependence on relatively few variable region genes
8. Murine T-cell receptor mutants with deletions of beta-chain variable region genes
9. The T cell repertoire may be biased in favor of MHC recognition
10. Characterization of murine thymocytes with CD3-associated T-cell receptor structures
11. Heavy chain variable region
12. Intestinal intraepithelial lymphocytes are a distinct set of γδ T cells
13. A T-cell receptor γ/CD3 complex found on cloned functional lymphocytes
14. Two subsets of human T lymphocytes expressing gamma/delta antigen receptor are identifiable by monoclonal antibodies directed to two distinct molecular forms of the receptor
15. Identification of a putative second T-cell receptor
16. A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation
17. T-cell receptor δ gene rearrangements in early thymocytes
18. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
19. Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin
20. T-cell antigen receptor genes and T-cell recognition
21. κ joining reactions in human lymphoid cell lines
22. Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells
23. The adult T-cell receptor δ-chain is diverse and distinct from that of fetal thymocytes
24. + intraepithelial lymphocytes
25. β and MHC restriction
26. The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody
27. Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors
28. Structure, organization, and somatic rearrangement of T cell gamma genes
29. Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins
30. T-cell γ gene is allelically but not isotypically excluded and is not required in known functional T-cell subsets
31. Variable region genes in the human T-cell rearranging gamma (TRG) locus: V-J junction and homology with the mouse genes
32. Different γδ T-cell receptors are expressed on thymocytes at different stages of development
33. Monoclonal antibodies specific to native murine T cell receptor γδ: analysis of γδ T cells in thymic ontogeny and peripheral lymphoid organs
34. Specificity and function of T cells bearing γδ receptors
35. + dendritic epidermal cell lines
36. Predominant variable region gene usage by γ/δ T cell receptor-bearing cells in the adult thymus
37. Limited diversity of the rearranged T-cell γ gene
38. Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments
39. + dendritic epidermal cells
40. T-cell receptor δ-chain diversity in peripheral lymphocytes
41. Increased frequency of N-region insertion in a murine pre-B-cell line infected with a terminal deoxynucleotidyl transferase retroviral expression vector
42. DNA elements are assymetrically joined during the site-specific recombination of kappa immunoglobulin genes
43. Novel strand exchanges in V(D)J recombination
44. Lymphoid V(D)J recombination: nucleotide insertion at signal joints as well as coding joints
45. The defect in murine severe combined immune deficiency: joining of signal sequences by not coding segments in V(D)J recombination
46. Human T-cell receptor delta chain: genomic organization, diversity, and expression in populations of cells
47. Polymerase chain reaction with single-sided specificity: analysis of T cell receptor delta chain
48. The role of DNA rearrangement and alternative RNA processing in the expression of immunoglobulin delta genes
49. Direct evidence for chromosomal inversion during T-cell receptor β-gene rearrangements
50. The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism
51. L gene rearrangement involves deletion of a circular episome and addition of single nonrandom nucleotides to both coding segments
52. Clonotypic structures involved in antigen-specific human T-cell function
53. Are anti-arsonate antibody N-segments selected at both the protein and the DNA level?
54. Construction of improved M13 vectors using oligonucleotide-directed mutagenesis
55. Secondary tertiary and quaternary structure of T-cell-specific immunoglobulin-like polypeptide chains
56. T cell receptor β gene sequences in the circular DNA of thymocyte nuclei direct evidence for intramolecular DNA deletion of V-D-J joining
57. Aberrant immunoglobulin gene rearrangement in SCID mouse bone marrow cells
58. Structure, expression and divergence of T-cell receptor beta-chain variable regions
59. Analysis of antibody diversity: V-D-J mRNA. nucleotide sequence of four anti-GAT monoclonal antibodies
60. Selection of variable-joining region combinations in the alpha chain of the T cell receptor
61. Clonal proliferation unlinked to terminal deoxynucleotidyl transferase synthesis in thymocytes of young mice
62. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase
63. Complete primary structure of heterodimeric T-cell receptor deduced from cDNA sequences
64. DNA sequencing with chain-terminating inhibitors
65. T cell receptor-γ and -δ genes preferentially utilized by adult thymocytes for the surface expression
66. γδ T cell receptors on murine intestinal intra-epithelial lymphocytes are highly diverse
67. Somatic generation of antibody diversity
68. Normal T cell development is possible without “functional” gamma chain genes
69. Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy
70. Expression of T3 in association with a molecule distinct from the T-cell antigen receptor heterodimer
71. somatic evolution of variable region structures during an immune response