Biology of the protein kinase C family

CANCER AND METASTASIS REVIEW

Volumn 8, Issue 3, 1989, Pages 199-214

  O'Brian, Catherine A ^a   Ward, Nancy E ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

protein kinase C (PKC); signal transduction; tumor promotion

Indexed keywords

ISOENZYME; PROTEIN KINASE C;

AMINO ACID SEQUENCE; ENZYMOLOGY; HUMAN; METABOLISM; MOLECULAR GENETICS; NEOPLASM; REVIEW;

AMINO ACID SEQUENCE; HUMAN; ISOENZYMES; MOLECULAR SEQUENCE DATA; NEOPLASMS; PROTEIN KINASE C; SUPPORT, NON-U.S. GOV'T;

EID: 0024780428     PISSN: 01677659     EISSN: 15737233     Source Type: Journal    
DOI: 10.1007/BF00047337     Document Type: Article

References (129)

1. The molecular heterogenecity of protein kinase C and its implications for cellular regulation
2. Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways
3. Cloning and expression of multiple protein kinase C cDNAs
4. Isolation of cDNA clones encoding protein kinase C: Evidence for a protein kinase C-related gene family
5. Inositol phospholipids and cell surface receptor function
6. Inositol trisphosphate and diacylglycerol: two interacting second messengers
7. Studies and perspectives of protein kinase C
8. Isozymic forms of rat brain Ca2+-activated and phospholipid-dependent protein kinase
9. Purification and characterization of three types of protein kinase C from rabbit brain cytosol
10. Immunochemical identification of protein kinase C isozymes as products of discrete genes
11. Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues
12. Proteolytic activation of calcium-activated, phospholipid-dependent protein kinase by calcium-dependent neutral protease
13. Protein kinase C contains a pseudosubstrate prototope in its regulatory domain
14. Magnetic resonance studies of the effect of the regulatory subunit on metal and substrate binding to the catalytic subunit of bovine heart protein kinase
15. Studies of the mechanism of action and regulation of cAMP-dependent protein kinase
16. Autoregulation of enzymes by pseudosubstrate prototopes: Myosin light chain kinase
17. Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover
18. Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters
19. Phospholipid-sensitive Ca2+ dependent protein kinase from heart
20. Activation of protein kinase C by tumor promoting phorbol esters, teleocidin and aplysiatoxin in the absence of added calcium
21. The complete primary structure of protcin kinase C-the major phorbol ester tumor promoter receptor
22. The origins of human cancer: Molecular mechanisms of carcinogenesis and their implication for cancer prevention and treatment
23. Absence of protein kinase C in nuclei of EL4 mouse thymoma cells
24. Calcium-activated, phospholipid-dependent protein kinase (protein kinase C) from rat brain
25. Protein kinase C phosphorylates the synthetic peptide Arg-Lys-Arg-Ala-Ser-Gly-Pro-Pro-Val in the presence of phospholipid plus either Ca2+ or a phorbol ester tumor promoter
26. Substrate specificity of phospholipid/Ca2+-dependent protein kinase as probed with synthetic peptide fragments of the bovine myelin basic protein
27. Substrate specificity of protein kinase C: Use of synthetic peptides corresponding to physiological sites as probes for substrate recognition requirements
28. Synthesis of substrate of protein kinase C and its corresponding phosphopeptide
29. Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane
30. Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity
31. Receptors for epidermal growth factor and other polypeptide mitogens
32. Vinculin, a cytoskeletal substrate of protein kinase C
33. Phorbol ester- and protein kinase C-mediated phosphorylation of the cellular kirsten ras gene product
34. Protein kinase C catalyzes phosphorylation of guanylate cyclase in vitro
35. Protein kinase C phosphorylates human platelet inositol trisphosphate 5′-phosphomonoesterase, increasing the phosphatase activity
36. Phosphorylation of the 20,000-dalton light chain of smooth muscle myosin by the calcium-activated, phospholipid-dependent protein kinase
37. Calcium as an intracellular mediator of hormone action: Intracellular phospholipid signaling systems
38. Inositol phosphates: Synthesis and degradation
39. Inositol 1,3,4,5-tetrakisphosphate induces Ca2+ sequestration in rat liver cells
40. Type 1 phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate
41. PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells
42. Specificity of the fatty acyl moieties of diacylglycerol for the activation of calcium-activated, phospholipid-dependent protein kinase
43. Mechanisms of carcinogenesis using mouse skin: The multistage assay revisted
44. Critical genetic determinants and molecular events in multistage skin carcinogenesis
45. Variable potential for malignant conversion of papillomas induced by initiation-promotion protocols
46. Studies on the mechanims of action of tumor promoters and their relevance to mammary carcinogenesis
47. Activation of calcium-activated, phospholipid-dependent protein kinase (protein kinase C) by new classes of tumor promoters: teleocidin and debromoaplysiatoxin
48. Regulatory mechanisms in the control of protein kinases
49. Activation of protein kinase C by nonphorbol tumor promoter mezerein
50. Calcium and phospholipid-dependent protein kinase activity in mouse epidermal cytosol. Stimulation by complete and incomplete tumor promoters and inhibition by various compounds
51. Further characterization of tumor promoter-mediated activation of protein kinase C
52. Diversity in chemical nature of and mechanism of response to tumor promoters
53. Contrasting actions of staurosporine, a protein kinase C inhibitor, on human neutrophils and primary mouse epidermal cells
54. Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin
55. Bryostatin, an activator of the calcium phospholipid-dependent protein kinase, blocks phorbol ester-induced differentiation of human promyelocytic leukemia cells HL-60
56. Partial parallelism and partial blockade by bryostatin 1 of effects of phorbol ester tumor promoters on primary mouse epidermal cells
57. Bryostatin 1 antagonizes the terminal differentiating action of 12-0-tetradecanoylphorbol-13-acetate in a human colon cancer cell line
58. Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C
59. Demonstration of subnanomolar affinity of bryostatin 1 for the phorbol ester receptor in rat brain
60. Phorbol ester induction of 8-lipoxygenase in inbred SENCAR (SSIN) but not C57BL/6J mice correlated with hyperplasia, edema, and oxidant generation but not ornithine decarboxylase induction
61. Tumor promoter phorbol 12-myristate 13-acetate induces a clastogenic factor in human lymphocytes
62. Dietary carcinogens and anticarcinogens
63. Biochemical responses in activated human neutrophils mediated by protein kinase C and a Ca2+-requiring protease
64. A potential second messenger role for unsaturated fatty acids: Activation of Ca2+-dependent protein kinase
65. Palytoxin is a non-12-0-tetradecanoylphorbol-13-acetate type tumor promoter in two-stage mouse skin carcinogenesis
66. Activation of rat brain protein kinase C by lipid oxidation products
67. Activation of protein kinase C by lipoxin A and other eicosanoids. Intracellular action of oxygenation products of arachidonic acid
68. Calcium independent activation of hypothalamic type 1 protein kinase C by unsaturated fatty acids
69. Selective activation of the γ-subspecies of protein kinase C from bovine cerebellum by arachidonic acid and its lipoxygenase metabolites
70. Protein kinase C phosphorylates pp60src at a novel site
71. Ras GTPase activating protein: signal transmitter and signal terminator
72. A thousand and one protein kinases
73. The protein-tyrosine kinase substrate p36 is also a substrate for protein kinase C in vitro and in vivo
74. The tumor promoter phorbol 12-myristate 13-acetate induces a program of altered gene expression similar to that induced by platelet-derived growth factor and transforming oncogenes
75. A protein kinase C cDNA without the regulatory domain is active after transfection in vivo in the absence of phorbol ester
76. Down-regulation of protein kinase C and of an endogenous 80K-Da substrate in transformed fibroblasts
77. Partial downregulation of protein kinase C in C3H 10T 1/2 mouse fibroblasts transfected with the human Ha-ras oncogene
78. Ras-transformed cells: altered levels of phosphatidylinositol-4,5-bisphosphate and catabolites
79. Rapid stimulation of dia cylglycerol production in Xenopus oocytes by microinjection of H-ras p21
80. A monoclonal antibody recognizing the site of limited proteolysis of protein kinase C
81. Overproduction of protein kinase C causes disordered growth control in rat fibroblasts
82. Altered growth regulation and enhanced tumorigenicity of N1H3T3 fibroblasts transfected with protein kinase C-1 cDNA
83. Cysteinerich regions conserved in amino-terminal halves of raf gene family products and protein kinase C
84. Promoting effect of bile acids in colon carcinogenesis in germ-free and conventional rats
85. Promoting effect of sodium deoxycholate on colon adenocarcinomas in germ-free rats
86. Promotive effects of steroids and bile acids on hepatocarcinogenesis initiated by diethylnitrosamine
87. Potential tumor-promoting activity of bile acids in glandular stomach
88. Promoting effect of bile acids on the chemical transformation of C3H 10T 1/2 fibroblasts in vitro
89. Nutrition in the prevention of neoplastic disease in the elderly
90. Calcium ameliorates the toxic effect of deoxycholic acid on colonic epithelium
91. Calcium modification of the promoting stimulus of fatty acids to the colonic epithelium
92. The regulation of protein kinase C by chenodeoxycholate, deoxycholate, and several structurally related bile acids
93. The bile acid analog fusidic acid can replace phosphatidylserine in the activation of protein kinase C by 12-0-tetradecanoylphorbol-13-acetate in vitro
94. Purification of phosphatidylinositol-specific phospholipase C from rat liver
95. Role of activation of protein kinase C in the stimulation of colonic epithelial proliferation and reactive oxygen formation by bile acids
96. Studies on protein kinase C and colon carcinogenesis
97. Altered levels of protein kinase C and Ca2.-dependent protein kinases in human colon carcinomas
98. Decreased protein kinase C activity in psoriatic versus normal epidermis
99. Antiproliferative properties of phorbol ester tumor promoters
100. Subcellular distribution of protein kinase C in rat colonic epithelial cells with different proliferative activities
101. Phorbol esters inhibit the proliferation of MCF-7 cells
102. Effects of tumor promoters on growth and on cellular redistribution of phospholipid/Ca2+-dependent protein kinase in human breast cancer cells
103. Protein kinase C desensitization by phorbol esters and its impact on growth of human breast cancer cells
104. The cytosolic phorboid receptor correlates with hormone dependency in six mammary carcinoma cell lines
105. Epidermal growth factor binding and protein kinase C activities in human breast cancer cell lines: Possible quantitative relationship
106. Immunological quantitation of phospholipid/Ca2--dependent protein kinase of human mammary carcinoma cells: Inverse relationship to estrogen receptors
107. Phorbol ester and epidermal growth factor receptors in human breast cancer
108. Elevated protein kinase C expression in human breast tumor biopsies relative to normal breast tissue
109. Tamoxifen in advanced breast cancer
110. Determination of tamoxifen and biologically active metabolites in human breast tumors and plasma
111. Inhibition of protein kinase C by tamoxifen
112. Effect of tamoxifen, a nonsteriodal antiestrogen, on phospholipid/calcium-dependent protein kinase and phosphorylation of its endogenous substrate proteins from the rat brain and ovary
113. Triphenylethylenes: A new class of protein kinase C inhibitors
114. The mechanism of action of protein kinase C: new insights through the study of inhibitors and gene cloning
115. Tamoxifen is a calmodulin antagonist in the activation of cAMP phosphodiesterase
116. In vitro inhibition of rat brain protein kinase C by rhodamine 6G: Profound effects of the lipid cofactor on the inhibition of the enzyme
117. Specific and direct binding of protein kinase C to an immobilized tamoxifen analogue
118. Binding of protein kinase C to naphthalene-sulfonamide and phenothiazine agarose columns: evidence for direct interactions between protein kinase C and cationic amphiphilic inhibitors of the enzyme
119. Role of specific interactions between protein kinase C and triphenylethylenes in inhibition of the enzyme
120. Mechanisms of multidrug resistance and implications for therapy
121. Multidrug resistance
122. Transient protection of cultured human cells against antitumor agents by 12-0-tetradecanoyl-phorbol-13-acetate
123. Phorbol esters induce multidrug resistance in human breast cancer cells
124. Circumvention of multiple-drug resistance in human cancer cells by thioridazine, trifluoperazine, and chlorpromazine
125. Level of protein kinase C activity correlates directly with resistance to adriamycin in murine fibrosarcoma cells
126. Role of protein kinase C in phosphorylation of vinculin in adriamycin-resistant HL-60 leukemia cells
127. Phosphorylation of the Mr 170,000 to 180,000 glycoprotein specific to multidrug-resistant tumor cells: effects of verapamil, trifluoperazine, and phorbol esters