Steroid receptors. How to be both a receptor and a transcription factor

Biochemical Pharmacology

Volumn 38, Issue 19, 1989, Pages 3135-3143

  Godowski, Paul J ^a   Picard, Didier ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; DNA; ESTRADIOL; ESTROGEN RECEPTOR; GLUCOCORTICOID RECEPTOR; PROGESTERONE RECEPTOR; STEROID RECEPTOR; HORMONE; TRANSCRIPTION FACTOR;

GENETIC ENGINEERING; GENETIC TRANSCRIPTION; HORMONE BINDING; HUMAN; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; RAT; SHORT SURVEY; ANIMAL; BINDING SITE; METABOLISM; PHYSIOLOGY; REVIEW;

ANIMAL; BINDING SITES; DNA; HORMONES; HUMAN; RECEPTORS, GLUCOCORTICOID; RECEPTORS, STEROID; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0024745686     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(89)90605-9     Document Type: Article

References (72)

1. Steroid receptor regulated transcription of specific genes and gene networks
2. The steroid and thyroid hormone receptor superfamily
3. Nuclear receptors enhance our understanding of transcription regulation
4. The structure and function of steroid receptor proteins
5. The chicken oestrogen receptor sequence: homology with v-erbA and the human oestrogen and glucocorticoid receptors
6. The c-erbA protein is a high-affinity receptor for thyroid hormone
7. The c-erbA gene encodes a thyroid hormone receptor
8. Functional dissection of the hormone and DNA binding activities of the glucocorticoid receptor
9. Oestradiol induction of a glucocorticoid-responsive gene by a chimaeric receptor
10. The primary structure of transcription factor TFIIIA has 12 consecutive repeats
11. Repetitive zincbinding domains in the protein transcription factor IIIA from Xenopus oocytes
12. The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain
13. Metal binding finger structures in the glucocorticoid receptor defined by site-directed mutagenesis
14. Genomic organization of the human estrogen receptor gene
15. Structure of the chromosomal chicken progesterone receptor gene
16. Cloning of the chicken progesterone receptor
17. The N-terminal DNA-binding “zinc finger” of the oestrogen and glucocorticoid receptors determines target gene specificity
18. The chicken progesterone receptor: sequence, expression and functional analysis
19. Genetic complementation of a glucocorticoid receptor deficiency by expression of cloned receptor cDNA
20. The A and B forms of the chicken progesterone receptor arise by alternate initiation of translation of a unique mRNA
21. The N-terminal region of the chicken progesterone receptor specifies target gene activation
22. Functional domains of the human estrogen receptor
23. Relative selectivities and efficiencies of DNA binding by purified intact and protease-cleaved glucocorticoid receptor
24. Domains of the glucocorticoid receptor involved in specific and non-specific DNA binding, hormone activation and transcriptional enhancement
25. The oestrogen receptor binds tightly to its responsive element as a ligandinduced homodimer
26. Thyroid hormone receptor α isoforms generated by alterNatlve splicing differentially activate myosin HC gene transcription
27. Alternative splicing generates messages encoding rat cerbA proteins that do not bind thyroid hormone
28. Functional domains of the human glucocorticoid receptor
29. The mouse glucocorticoid receptor: mapping of functional domains by cloning, sequencing and expression of wildtype and mutant receptor proteins
30. Selective covalent labeling of cysteines in bovine serum albumin and in hepatoma tissue culture cell glucocorticoid receptors by dexamethasone 21-mesylate
31. Identification of cysteine 656 as the amino acid of hepatoma tissue culture cell glucocorticoid receptors that is covalently labeled by dexamethasone 21-mesylate
32. Identification of hormone-interacting amino acid residues within the steroid-binding domain of the glucocorticoid receptor in relation to other steroid hormone receptors
33. Homologous sequences in steroidogenic enzymes, steroid receptors and a steroid binding protein suggest a consensus steroid-binding sequence
34. Characterization of the hormone-binding domain of the chicken c-erbA/thyroid hormone receptor protein
35. The common 90-kD protein component of non-transformed “8S” steroid receptors is a heat-shock protein
36. A 90,000-dalton binding protein common to both steroid receptors and the Rous sarcoma virus transforming protein pp60v-src
37. The 90 kD non-steroid-binding phosphoprotein that binds to the untransfonned glucocorticoid receptor in molybdate-stabilized L-cell cytosol is the murine 90 kD heat shock protein
38. Relationship of the 90 kD murine heat shock protein to the untransformed and transformed states of the L-cell glucocorticoid receptor
39. Evidence for intracellular association of the glucocorticoid receptor with the 90 kD heat shock protein
40. Glucocorticoid receptor complexes and the earliest steps in the action of glucocorticoids on thymus cells
41. Subunit dissociation as a possible mechanism of glucocorticoid receptor activation
42. Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor
43. Receptors from glucocorticoid-sensitive lymphoma cells and two classes of insensitive clones physical and DNA-binding properties
44. Requirement of hormone for thermal conversion of the glucocorticoid receptor to a DNA-binding state
45. Glucocorticoid receptor mutants that are constitutive activators of transcriptional enhancement
46. A region in the steroid binding domain determines formation of the nonDNA-binding, 9S glucocorticoid receptor complex
47. A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor
48. The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function
49. Signal transduction and transcriptional regulation by glucocorticoid receptor-LexA fusion proteins
50. Glucocorticoid receptor phosphorylation transformation and DNA binding
51. The human oestrogen receptor functions in yeast
52. Mammalian glucocorticoid receptor derivatives enhance transcription in yeast
53. Glucocorticoid receptors recognize DNA sequences in and around murine mammary tumor virus DNA
54. Purified glucocorticoid receptor-hormone complex from rat liver cytosol binds specifically to cloned mouse mammary tumor virus long terminal repeats in vitro
55. Purified glucocorticoid receptors bind selectively in vitro to a cloned DNA fragment whose transcription is regulated by glucocorticoids in vitro
56. Specific binding of the glucocorticoid-receptor complex to the mouse mammary tumor proviral promoter region
57. DNA sequences bound specifically by glucocorticoid receptor in vitro render a heterologous promoter hormone responsive in vivo
58. Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIa gene
59. Cooperativity of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene
60. Sequence homologies in the region preceding the transcription initiation site of the liver estrogenresponsive vitellogenin and apo-VLDLII genes
61. The estrogen responsive elements as an inducible enhancer: DNA sequence requirements and its conversion to a glucocorticoid responsive element
62. Molecular interactions of steroid hormone receptor with its enhancer element: evidence for receptor dimer formation
63. Hormone-mediated repression: a negative glucocorticoid response element from the bovine prolacting gene
64. Glucocorticoid receptor mutants that define a small region sufficient for enhancer activation
65. How eukaryotic transcriptional activators work
66. Synergistic action of the glucocorticoid receptor with transcription factors
67. Many transcription factors interact synergistically with steroid receptors
68. Mechanism of action of a yeast activator: direct effect of Ga4 derivatives on mammalian TFIID-promoter interactions
69. Transcription factor ATF interacts with the TATA factor to facilitate establishment of a preinitiation complex
70. Steroiddependent interaction of transcription factors with the inducible promoter of mouse mammary tumor virus in vivo
71. Negative regulation by glucocorticoids through interference with a cAMP responsive enhancer
72. Signal transduction and transcriptional regulation by the glucocorticoid receptor