Kinetic study of the interaction of glutathione with four antitumor disulfides: Possible mechanism for cellular glutathione depletion

Chemico-Biological Interactions

Volumn 69, Issue 2-3, 1989, Pages 225-234

  Kirkpatrick, D Lynn ^a  

^a UNIVERSITY OF REGINA   (Canada)

Author keywords

Antitumor; Disulfides; Glutathione; Kinetic

Indexed keywords

6 MERCAPTOPURINE DERIVATIVE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; THIOGUANINE DERIVATIVE;

ANIMAL CELL; KINETICS; NONHUMAN; PRIORITY JOURNAL;

6-MERCAPTOPURINE; ANTINEOPLASTIC AGENTS; DISULFIDES; GLUTATHIONE; GLUTATHIONE DISULFIDE; KINETICS; SPECTROPHOTOMETRY, ULTRAVIOLET; SUPPORT, NON-U.S. GOV'T; THIOGUANINE;

EID: 0024602395     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/0009-2797(89)90080-X     Document Type: Article

References (8)

1. Modification of antitumor disulfide cytotoxicity by glutathione depletion in murine cells
2. Antitumor activity of alkyldisulfide derivatives of 6-mercaptopurines against L-1210 leukemia
3. Synthetic nucleosides and nucleotides X Synthesis and biological activities of several pyrin-6-yl benzyl disulfides and their ribonculeosides
4. S-Alkylthioisothioureas
5. Computer-assisted analysis of reaction rate data
6. Rate constants and equilibrium constants for thiol-disulfide interchange reactions involving oxidized glutathione
7. A demonstration of the reactivity-selectivity principle for the thiol-disulfide interchange reaction
8. Thiol reactive nitroimidazoles; radiosensitization studies in vitro and in vivo