Race and Therapeutic Drug Response

New England Journal of Medicine

Volumn 320, Issue 9, 1989, Pages 588-590

  Kalow, W ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PROPRANOLOL;

BLOOD PRESSURE; CAUCASIAN; CHINESE; DRUG METABOLISM; EDITORIAL; ETHNIC OR RACIAL ASPECTS; HEART RATE; HUMAN; HUMAN EXPERIMENT; HYPERTENSION; NEGRO; NORMAL HUMAN; PRIORITY JOURNAL;

EID: 0024600648     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM198903023200909     Document Type: Editorial

References (11)

1. Zhou H-H, Koshakji RP, Silberstein DJ, Wilkinson GP, Wood AJJ. Racial differences in drug response: altered sensitivity to and clearance of propranolol in men of Chinese descent as compared with American whites. N Engl J Med 1989; 320: 565–70.
2. Freis ED. Antihypertensive agents. In: Kalow W, Goedde HW, Agarwal DP, eds. Ethnic differences in reactions to drugs and xenobiotics. New York: Alan R. Liss, 1986:313–22.
3. Walle T, Byington RP, Furberg CD, Mclntyre KM, Vokonas PS. Biologic determinants of propranolol disposition: results from 1308 patients in the Beta-Blocker Heart Attack Trial. Clin Pharmacol Ther 1985; 38: 509–18.
4. Sharoky M, Perkal M, Turner R, Lesko LJ. Steady state relative bioavailability and pharmacokinetics of oral propranolol in black and white North Americans. Biopharm Drug Dispos 1988; 9: 447–56.
5. Raghuram TC, Koshakji RP, Wilkinson GR, Wood AJ. Polymorphic ability to metabolize propranolol alters 4-hydroxypropranolol levels but not beta blockade. Clin Pharmacol Ther 1984; 36: 51–6.
6. Skoda RC, Gonzalez FJ, Demierre A, Meyer UA. Two mutant alleles of the human cytochrome P-450dbl gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs. Proc Natl Acad Sci USA 1988; 85: 5240–3.
7. Agarwal DP, Goedde W. Ethanol oxidation: ethnic variations in metabolism and response. In: Kalow W, Goedde HW, Agarwal DP, eds. Ethnic differences in reactions to drugs and xenobiotics. New York: Alan R. Liss, 1986:99–112.
8. Comparison of alprazolam plasma levels in normal Asian and Caucasian male volunteers, K.-M., Lin, J.K., Lau, R., Smith, P., Phillips, E., Antal, R.E., Poland, Psychopharmacology, (1988), 96, 365-369
9. Kalow W. Pharmacoanthropology: outline, problems, and the nature of case histories. Fed Proc 1984; 43: 2314–8.
10. Kalow W, Goedde HW, Agarwal DP, eds. Ethnic differences in reactions to drugs and xenobiotics. New York: Alan R. Liss, 1986.
11. World Health Organization. The use of essential drugs: third report of the WHO Expert Committee (no. 770). Geneva: World Health Organization, 1988.