Molecular modeling of γ-lactam analogues of β-lactam antibacterial agents: synthesis and biological evaluation of selected penem and carbapenem analoques

Tetrahedron

Volumn 45, Issue 7, 1989, Pages 1905-1928

  Allen, Norris E ^a   Boyd, Donald B ^a   Campbell, Jack B ^a   Deeter, Jack B ^a   Elzey, Thomas K ^a   Foster, Bennie J ^a   Hatfield, Lowell D ^a   Hobbs Jr , Joseph N ^a   Hornback, William J ^a   Hunden, David C ^a   Jones, Noel D ^a   Kinnick, Michael D ^a   Morin Jr , John M ^a   Munroe, John E ^a   Swartzendruber, John K ^a   Vogt, David G ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 [2 (2 AMINO 4 THIAZOLYL) 2 METHOXYIMINOACETAMIDO] 3 METHYL 8 OXO 4 THIA 1 AZABICYCLO[3.3.0]OCT 2 ENE 2 CARBOXYLIC ACID; AMOXICILLIN; CARBAPENEM DERIVATIVE; CEFALORIDINE; GAMMA LACTAM DERIVATIVE; UNCLASSIFIED DRUG;

CELL CULTURE; COMPUTER ANALYSIS; COMPUTER MODEL; DRUG RESEARCH; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

EID: 0024597718     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(01)80055-7     Document Type: Article

References (97)

1. The Synthesis of Analogs of Penicillin.1aI
2. ?-Lactam analogues of penicillanic and carbapenicillanic acids
3. ?-Lactam analogues of carbapenicillanic acids
4. Numerical sensitivity of trajectories across conformational energy hypersurfaces from geometry optimized molecular orbital calculations: AM1, MNDO, and MINDO/3
5. The acylating potential of .gamma.-lactam antibacterials: base hydrolysis of bicyclic pyrazolidinones
6. .beta.-Lactam antibiotics: geometrical requirements for antibacterial activities
7. Structure of sulfazecin–methanol (1/1)
8. Computer-Assisted Molecular Design(CAMD)—An Overview
9. The structure of amoxycillin trihydrate and a comparison with the structures of ampicillin
10. A simple and efficient synthesis of the ?-lactam analogue of ?-lactam antibiotics. Ring-expansion of penicillins to homopenicillins
11. II. Synthese der Pyrazolin-3,5-dicarbonsäure
12. Stereospecific synthesis of penicillins. Conversion from a peptide precursor
13. A GENERAL ASYMMETRIC CYCLIZATION. ASYMMETRIC SYNTHETHIS OF OPTICALLY ACTIVE 2-OXO-5-PYRROLIDINEACETIC ACID DERIVATIVES
14. One-pot transformation of ketones to .ALPHA., .BETA.-unsaturated nitriles via trimethylsiloxy nitriles.
15. Synthesis of ?-lactam analogues of carbapenems with substituted-thio groups at the C-3 position