Cardiovascular consequences of magnesium deficiency and loss: Pathogenesis, prevalence and manifestations-Magnesium and chloride loss in refractory potassium repletion

The American Journal of Cardiology

Volumn 63, Issue 14, 1989, Pages

  Seelig, Mildred ^a,b  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b American College of Nutrition   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOLAMINE; MAGNESIUM; POTASSIUM;

DIET; FATALITY; HUMAN; MAGNESIUM DEFICIENCY; NORMAL VALUE; PRIORITY JOURNAL; SHORT SURVEY; STRESS; SUDDEN DEATH;

CARDIOVASCULAR AGENTS; CARDIOVASCULAR DISEASES; CHLORIDES; DIET; FEMALE; HEART DISEASES; HUMAN; HYPERTENSION; MAGNESIUM; MAGNESIUM DEFICIENCY; POTASSIUM; PREGNANCY; STRESS;

EID: 0024589887     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/0002-9149(89)90213-0     Document Type: Article

References (237)

1. A preliminary report on the intravenous use of magnesium sulphate in puerperal eclampsia
2. The use of magnesium in the management of ecalmptic toxemias
3. Magnesium sulfate in paroxysmal tachycardia
4. The action of magnesium on the heart
5. Magnesium deficiency and cardiac disorders
6. Hypomagnesemia and refractory arrhythmia in a nondigitalized patient
7. Magnesium and cardiac arrhythmias
8. Hormone-electrolyte interactions in the pathogenesis of lethal cardiac arrhythmias in patients with congestive heart failure: basis of a new physiologic approach to control of arrhythmia
9. The mitochondrial system of enzymes
10. Magnesium interrelationships in ischemic heart disease
11. Tissue electrolyte alteration in disseminated myocardial necrosis
12. Relations between mortality from cardiovascular disease and treated water supplies
13. Ischaemic heart disease and soil magnesium in Finland (letter)
14. Role of magnesium in the “hard water story”
15. Ischemic heart disease, water hardness, and myocardial magnesium
16. Sudden death from ischemic heart disease in Ontario and its correlation with water hardness and other factors
17. Hypomagnesemia and vasoconstriction: possible relationship to etiology of sudden death ischemic disease and hypertensive vascular disease
18. Magnesium depletion as a cause of refractory potassium repletion
19. Diuretics and potassium/magnesium depletion: directions for treatment
20. Potassium/magnesium depletion in patients with cardiovascular disease
21. Acid base metabolism
22. Complications of thiazide therapy: an update
23. The requirement of magnesium by the normal adult
24. Magnesium requirements in human nutrition
25. Recommended dietary allowances
26. Food and nutrient intakes of individuals on 1 day in the US: Spring 1977
27. Magnesium and calcium intakes of the US population
28. Magnesium intakes, balances, and blood levels of adults consuming self-selected diets
29. Nutritive content of college meals: III. Mineral elements
30. Inorganic elements in weighted diets of girls and young women
31. Magnesium and the arteries: I. Effects of magnesium deficiency on arteries and on the retention of sodium, potassium and calcium
32. Magnesium and lipid interrelationships in the pathogenesis of vascular diseases
33. Lipoprotein metabolism: importance of magnesium
34. Magnesium and lipids in cardiovascular disease
35. Interrelationships between experimental hypercholesterolemia magnesium requirements and experimental atherosclerosis
36. Influence of dietary magnesium on cardiac and renal lesions of young rats fed an atherogenic diet
37. Magnesium deficiency in the cebus monkey
38. Magnesium metabolism in health and disease
39. The role of magnesium in blood coagulation
40. Effect of magnesium deficiency on lipid metabolism in rats fed a high carbohydrate diet
41. The reduction of plasma triglyceride clearance by magnesium-deficient rats
42. Studies on magnesium deficiency in animals: III. Chemical changes in the blood following magnesium deprivation
43. Reduction of plasma lecithin-cholesterol acetyltransferase activity by acute magnesium deficiency in the rat
44. Monotherapy with magnesium increases abnormally low high-density lipoprotein cholesterol: a clinical assay
45. Influence of various nutrients on urinary divalent cation excretion
46. Clinical magnesium deficiency
47. Serum potassium magnesium and calcium levels in diabetic acidosis
48. Morphologic and hemodynamic changes in the smaller blood vessels in diabetes mellitus. I. Considerations based on the literature
49. Pathology of small coronary arteries
50. Correlation of vitamin D intake to ischemic heart disease, hypercholesterolemia, and renal calcinosis in nutritional imbalances in infant and adult disease
51. Multiple factors in the hyperlipidemia of hypervitaminosis D (letter)
52. The mode of action of vitamin D: The “parathyroid” theory: clinical hypervitaminosis
53. Biochemical studies in idiopathic hypercalcemia in infancy
54. Vitamin D and cardiovascular, renal, and brain damage in infancy and childhood
55. Magnesium deficiency with phosphate and vitamin D excesses: role in pediatric cardiovascular disease?
56. 1,25-dihydroxycholecalciferol—a hormonally active form of vitamin D3
57. An investigation into nutritional factors of experimental cardiopathy
58. Epidemiologic studies on the relationship between magnesium intake and cardiovascular diseases
59. Effects of ethanol administration on urinary excretion of magnesium and other electrolytes in alcoholic and normal subjects
60. Normal renal magnesium clearance and the effect of water loading, chlorthiazide and ethanol on magnesium clearance
61. Urinary excretion of magnesium in man following the ingestion of alcohol
62. Magnesium deficiency after prolonged parenteral fluid administration and after chronic alcoholism complicated by delirium tremens
63. Magnesium deficiency in alcoholism
64. Effect of aldosterone on the metabolism of magnesium
65. Relationship of free fatty acids and magnesium in ethanol withdrawal in dogs
66. Influence of magnesium deficiency on the utilization of thiamine
67. Thiamine metabolism in magnesium-deficient rats
68. Effect of thiamine on growth, tissue magnesium and thiamine levels and on transketolase in magnesium deficient rats
69. Nutritional status and requirements of magnesium
70. Phosphor calcium and magnesium
71. Magnesium intake during pregnancy
72. Dietary assessment of pregnant women in a supplemental food program
73. The retention of calcium, phosphorus and magnesium during pregnancy: the adequacy of prenatal diets with and without supplementation
74. Magnesium contents of pregnant women
75. Possible roles of magnesium in disorders of the aged
76. Magnesium metabolism: Studies in health, primary hyperparathyroidism and renal stone disease
77. Effects of aging, chronic disease, and multiple supplements on magnesium requirements
78. Nutritional status of instutitionalized and non-institutionalized aged in Belfast
79. Hypomagnesemia and transient ischemia cerebral attacks
80. Long-term effect of subnormal magnesium on magnesium and calcium contents of organs, on cold tolerance and on lifespan and its pathological consequences in rats
81. Relationship of juxtaglomerular apparatus and adrenal cortex to biochemical and extracellular fluid volume changes in magnesium deficiency
82. Spontaneous hypopotassemia, hypomagnesemia, alkalosis and tetany due to hypersecretion of corticosterone-like mineralocorticoid
83. The effects of alkaline earths and other divalent cations on adrenal medullary secretion
84. The action of extracellular cations on the release of the sympathetic transmitter from peripheral nerves
85. Interaction of noise-induced stress and Mg decrease
86. Stress-induced Ca/Mg shifts and vascular response in animals and men: comparison to electrolyte alterations in myocardial infarction patients
87. Role of magnesium in cardiac disease
88. Correlation of myocardial and renal necrosis with tissue electrolyte changes
89. Effects of acetylsalicylic acid, dipyridamole, and hydrocortisone on epinephrine-induced myocardial injury in dogs
90. Magnesium and cardiac necrosis
91. Changes in the magnesium content of tissues following myocardial damage in rats
92. Myocardial fiber necrosis due to intracellular Ca overload—a new principle in cardiac pathophysiology
93. Evidence of a new preferentially Mg-carrying transport system besides the fast Na and the slow Ca channels in the excited myocardial sarcolemma membrane
94. Magnesium but not calcium accumulation is inhibited by β-adrenergic stimulation in S49 lymphoma cells
95. Hypomagnesemia resulting from adrenalin infusion in ewes: its relation to lipolysis
96. Alterations of long-chain free fatty acid and magnesium concentrations in acute myocardial infarction
97. Epinephrine and adrenocorticotropic hormone-stimulated magnesium accumulation in adipocytes and their plasma membranes
98. Lipolysis-induced Mg uptake into fat cells
99. Type A behavior and coronary vasospasm: a possible role of hypomagnesemia
100. Type A behavior and magnesium metabolism
101. Correlation of A-B behavior pattern, alcohol intake, HDL-cholesterol and serum magnesium levels in middle-aged men
102. Blood and urinary magnesium, zinc, calcium, free fatty acids and catecholamines in type A and type B subjects
103. Prevention of stress-induced cardiovascular damage
104. L'Enfant spasmophile—aspects diagnostiques et therapeutiques
105. The cardiomyopathy of Mg-deficiency
106. Cardiac necrosis and calcification in experimental magnesium deficiency
107. Effects of magnesium, ruthenium red, and the antibiotic ionophore A-23187 on initial rates of calcium uptake and release by heart mitochondria
108. Pathological accumulation of calcium by mitochondria: modulation by magnesium
109. Prevention of myocardial Ca overload and necrotization by Mg and K salts of acidosis
110. Possible role of magnesium loss in the pathogenesis of myocardial fiber necrosis
111. Contributions of electron microscopy to the study of myocardial ischemia
112. New perspectives on the role of magnesium in the pathophysiology of the cardiovascular system: I. Clinical aspects
113. New perspectives on the role of magnesium in the pathophysiology of the cardiovascular system: II. Experimental aspects
114. Coronary arterial lesions in Mg-deficient hamsters
115. Thrombosis as a factor in the pathogenesis of coronary atherosclerosis
116. Studies of platelet aggregation, plasma adenosine diphosphate breakdown, and blood coagulation in magnesium deficient calves and rats
117. The effect of agents which modify platelet behavior and of magnesium ions on thrombus formation in vivo
118. Effect of magnesium sulfate on thrombus formation following partial arterial constriction: implications for coronary vasospasm
119. Magnesium deficiency thrombosis (letter)
120. Pilule, et thrombose (des plaquettes, des estrogens et du magnesium)
121. Platelets, magnesium and myocardial infarction
122. Prompt termination and/or prevention of cold-pressor-stimulation-induced vasoconstriction of different beds by magnesium sulfate in patients with Prinzmetal's angina
123. The frequency and significance of coronary arterial thrombi and other observations in fatal acute myocardial infarction
124. The cardiomyopathies: order from chaos
125. Ischemic heart disease and magnesium
126. The pathogenesis of atherosclerosis II
127. Acute extracellular magnesium deficiency and myocardial tolerance to ischemia
128. Magnesium deficiency and myocardial infarct size in the dog
129. Myocardial protection during ischemic arrest: the importance of magnesium in cardioplegic infusates
130. The ionic basis of the anti-ischemic and antiarrhythmic properties of magnesium in the heart
131. Metabolic approaches to myocardial infarction
132. The nature of magnesium tetany
133. Electrocardiographic studies in dogs with experimental magnesium deficiency
134. The effects of prolonged hypomagnesemia on the cardiovascular system in young dogs
135. Effects of magnesium-deficient diet upon puppies
136. Electrocardiographic patterns of magnesium depletion appearing in alcoholic heart disease
137. The importance of magnesium deficiency in cardiovascular disease
138. Interactions of magnesium and potassium in the pathogenesis of cardiovascular disease
139. Parathyroid hormone secretion in magnesium deficiency
140. Magnesium: nature's physiologic calcium blocker
141. Magnesium: electrophysiological effects
142. Electrophysiologic effects of intravenous magnesium in patients with normal conduction systems and no clinical evidence of significant cardiac disease
143. Serum, lymphocyte, and erythrocyte potassium, magnesium, and calcium concentrations and their relation to tachyarrhythmias in patients with acute myocardial infarction
144. Alterations of electrolytes in serum and erythrocytes after myocardial infarction
145. Potassium and magnesium status in ischemic heart disease
146. Magnesium deficiency in patients with ischemic heart disease with and without acute myocardial infarction uncovered by an intravenous loading test
147. Low blood mononuclear cell magnesium in intensive cardiac care unit patients
148. Magnesium depletion in man
149. Alcoholic heart disease
150. The significance of hypomagnesemia in alcoholic patients
151. Paroxysmal ventricular fibrillation in two patients with hypomagnesemia treatment by transvenous pacing
152. Unusual T wave abnormality: repolarization alternans associated with hypomagnesemia, acute alcoholism, and cardiomyopathy
153. T-wave alternans associated with heart failure and hypomagnesemia in alcoholic cardiomyopathy
154. Magnesium deficiency complicating prolonged gastric suction
155. Magnesium deficiency in gastrointestinal fluid loss
156. Hypomagnesemia and ventricular tachycardia: a complication of ulcerative colitis and parenteral hyperalimentation in a non-digitalized non-cardiac patient
157. Tissue magnesium level in chronic diarrhea
158. The effect of magnesium therapy on cardiovascular and electrocardiographic changes in severe protein-calorie malnutrition
159. Hypomagnesemia with convulsions in a newborn infant: report of a case associated with maternal hypophosphatemia
160. Electrocardiographic changes in hypomagnesemia
161. Effect of ACD blood prime on plasma calcium and magnesium
162. Magnesium metabolism in patients undergoing cardiopulmonary bypass
163. Magnesium in patients undergoing open-heart surgery
164. Value of magnesium supplements during open-heart surgery: a double-blind trial
165. Magnesium in open-heart surgery
166. Cellular protection during myocardial ischemia. The development and characterization of a procedure for the induction of reversible ischemic arrest
167. Magnesium therapy in acute myocardial infarction
168. The clinical effects of magnesium sulphate treatment in acute myocardial infarction
169. Intravenous magnesium in acute myocardial infarction
170. Magnesium in the prevention of lethal arrhythmias in acute myocardial infarction
171. Justification for intravenous magnesium therapy in acute myocardial infarction
172. Serum magnesium in acute myocardial infarction
173. Sudden unexpected death in patients with congestive heart failure: a second frontier
174. Intracellular electrolytes in cardiac failure
175. Magnesium in cardiac failure and diuretic treatment
176. Immediate and long-term pathophysiologic mechanisms underlying the genesis of sudden cardiac death in patients with congestive heart failure
177. Neurohumoral mechanisms involved in congestive heart failure
178. Ventricular extrasystoles and intracellular electrolytes before and after potassium and magnesium infusions in patients on diuretic treatment
179. Prolapsus valvulaire mitral: spasmophilie et deficit magnesien
180. Magnesium deficiency in the pathogenesis of mitral valve prolapse
181. The variability of human red blood cell magnesium levels according to HLA groups
182. HLA antigens in mitral valve prolapse
183. Dietary aspects of the treatment of hypertension
184. Dietary calcium in human hypertension
185. The calcium deficiency hypothesis of hypertension: a critique
186. Magnesium and the Arteries: II. Physiologic effects of electrolyte abnormalities on arterial resistance
187. Interactions of Mg and K on blood vessels—aspects in view of hypertension: review of present status and new findings
188. Role of magnesium ions in contractility of blood vessels and skeletal muscles
189. Speculations on renal hormonal, and metabolic aberrations in a patient with marginal magnesium deficiency
190. Divalent cations in essential hypertension
191. Intracellular free magnesium in erythrocytes of essential hypertension: relation to blood pressure and serum divalent cations
192. Uniformity and diversity of calcium metabolism in hypertension a conceptual framework
193. Effects of magnesium infusions in diuretic induced hyponatremia
194. Effect of magnesium on blood pressure
195. On magnesium's effect on the heart
196. Serum magnesium and cardiac arrhythmias with special reference to digitalis intoxication
197. Correlation of serum magnesium levels and cardiac digitalis intoxication
198. Potassium, magnesium, and digitalis toxicity
199. Magnesium sulfate and digitalis-toxic arrhythmias
200. Frequency of hypomagnesemia in hospitalized patients receiving digitalis
201. Serum magnesium levels in symptomatic atrial fibrillation and their relation to rhythm control by intravenous digoxin
202. Role of calcium ions in transient inward current and after-contraction induced by strophanthidin in cardiac Purkinje fibers
203. Studies on magnesium's mechanism of action in digitalis-induced arrhythmias
204. The effectiveness of magnesium chloride in the treatment of ventricular tachyarrhythmias due to digitalis intoxication
205. Intracellular magnesium deficiency in man
206. Values for tissue magnesium as a guide in detecting magnesium deficiency
207. Uremia (Medical Progress series)
208. Diuretic-associated hypomagnesemia
209. Diuretic-associated hypomagnesemia in the elderly
210. Magnesium depletion, diuretics, and arrhythmias
211. Multiple risk factor intervention trial: risk factor changes and mortality results
212. Sudden death in men with increased risk of myocardial infarction—the MRFIT program
213. Diuretics and arrhythmias in the Medical Research Council Trial
214. Failure of therapy to improve the prognosis in elderly males with hypertension
215. Mortality and morbidity results from the European Working Party on High Blood Pressure in the Elderly trial
216. Relationship of diuretic therapy and serum magnesium levels among participants in the Multiple Risk Factor Intervention Trial
217. Acute metabolic alkalosis its effect on potassium and acid excretion
218. Factors governing correction of the alkalosis associated with potassium deficiency; the critical role of chloride in the recovery process
219. The critical role of chloride in the correction of hypokalemic alkalosis in man
220. Magnesium and potassium therapy in multifocal atrial tachycardia
221. The influence of venous occlusion and exercise on serum magnesium concentration
222. Hypermagnesemia from birth asphyxia
223. Systemic alkalosis and digitalis related arrhythmias
224. Hypokalemia and metabolic alkalosis resulting from overuse of magnesium oxide
225. Acid-base changes in rats kept on highly magnesium enriched diets using different magnesium compounds
226. Improvement of chlorine of the intestinal absorption of inorganic and organic Mg compounds and their protective effect against adrenergic cardiopathy
227. Magnesium and potassium deprivation and supplementation in animals and man: aspects in view of intestinal absorption
228. Prenecrotic electrolyte alterations of the adrenergic cardiopathy: potentiation by magnesium depletion and prevention by high dietary magnesium levels and verapamil
229. Age factor and myocardial necrosis experimental studies on the sensitizing effect of K- Mg- and Cl-deficiencies
230. The effect of oral magnesium chloride therapy on the QTc and QUc intervals of the electrocardiogram
231. Magnesium supplementation in hypertension treated with hydrochlorthiazide