Lysosome instability in aged rat brain

Neuroscience Letters

Volumn 97, Issue 1-2, 1989, Pages 215-220

  Nakamura, Yu ^a   Takeda, Masatoshi ^a   Suzuki, Hideo ^a   Morita, Hitoshi ^a   Tada, Kunitoshi ^a   Hariguchi, Shiro ^a   Nishimura, Tsuyoshi ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Aging; Cathepsin D; l Leu methyl ester; Lysosome; Glucuronidase

Indexed keywords

BETA GLUCURONIDASE; CATHEPSIN D;

ADOLESCENT; AGE; AGED; ANIMAL CELL; BRAIN HOMOGENATE; LYSOSOME; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT;

AGING; ANIMAL; BRAIN; CATHEPSIN D; CYTOSOL; GLUCURONIDASE; LEUCINE; LYSOSOMES; RATS; RATS, INBRED STRAINS; SUPPORT, NON-U.S. GOV'T;

EID: 0024576287     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(89)90166-3     Document Type: Article

References (12)

1. Proteolytic activity and basic protein loss in and around multiple sclerosis plaques: combined biochemical and histochemical observations
2. Enzymatic catalysis of glucuronyl transfer
3. Tissue fractionation studies 4. Comparative study of the binding of acid phosphatase, β-glucuronidase and cathepsin by rat-liver particles
4. Rupture of rat liver lysosomes mediated by 1-amino acid esters
5. Effects of anti-inflamatory drugs on the stability of rat liver lysosomes in vitro
6. Estimation of plasma phophatase by determination of hydrolysed phenol with amino-antipyrine
7. Age-related increase in a cathepsin D like protease that degrades brain microtubule-associated proteins
8. Intracellular disruption of heart lysosomes by leucine methyl ester: effect on protein degradation
9. The acidification rate of liver lysosomes in vitro: a role for the membranous ATPase as a proton pump
10. Change of cathepsin D activities in vinblastine-injected rabbit brain and Alzheimer's disease brain
11. Activities of lysosomal enzymes in rabbit brain with experimental neurofibrillary changes
12. Affinity purification and properties of cathepsin E like acid protease from rat spleen