Erythromycin and roxithromycin potentiate human neutrophil locomotion in vitro by inhibition of leukoattractant-activated superoxide generation and autooxidation

Journal of Infectious Diseases

Volumn 159, Issue 5, 1989, Pages 966-973

  Anderson, Ronald ^a  

^a UNIVERSITY OF PRETORIA   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; BENOXAPROFEN; CALCIMYCIN; ERYTHROMYCIN; MYELOPEROXIDASE; PROTEIN KINASE; RADIOISOTOPE; ROXITHROMYCIN; SUPEROXIDE;

AUTOOXIDATION; CALCIUM CELL LEVEL; CHEMOLUMINESCENCE; HUMAN; IODINATION; LEUKOCYTE MIGRATION; PRIORITY JOURNAL; SCAVENGING SYSTEM;

CALCIMYCIN; CELL MOVEMENT; ERYTHROMYCIN; HUMAN; IN VITRO; LEUCOMYCINS; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; OXIDATION-REDUCTION; PROPIONIC ACIDS; SUPEROXIDES; TETRADECANOYLPHORBOL ACETATE; ZYMOSAN;

EID: 0024566566     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/159.5.966     Document Type: Article

References (39)

1. Bass DA, Olbrantz P, Szejda P, Seeds MC, McCall CE. Sub populations of neutrophils with increased oxidative product formation in blood of patients with infection. J Immunol 1986;136:860-866
2. Maderazo EG, Woronick CL, Albano SD, Breaux SP, Pock RM. Inappropriate activation, deactivation, and probable autooxidative damage as a mechanism of neutrophil locomotory defect in trauma. J Infect Dis 1986;154:471-477
3. Baehner RL, Boxer LA, Allen JM, Davis J. Autooxidation as a basis for altered function by polymorphonuclear leukocytes. Blood 1977;50:327-335
4. Tsan MF. Phorbol myristate acetate induced neutrophil autotoxicity. J Cell Physiol 1980;105:327-334
5. 2/halide system: studies on the reversible nature of the inhibition and mechanism of protection of migratory responsiveness by ascorbate, levamisole, thiamine and cysteine. Int J Immunopharmacol 1983;5:377-391
6. Stendahl O, Coble BI, Dahlgren C, Hed J, Molin L. My eloperoxidase modulates the phagocytic activity of polymorphonuclear neutrophil leukocytes. Studies with cells from a myeloperoxidase-deficient patient. J Clin Invest 1984;73:366-373
7. Rajkovic IA, Williams R. Inhibition of neutrophil function by hydrogen peroxide. Effect of SH-group-containing compounds. Biochem Pharmacol 1985;34:2083-2090
8. 2/halide system in vitro and in vivo. Am J Clin Nutr 1981;34:1906-1911
9. Till GO, Lutz MJ, Ward PA. Hydroxyl radical as autotoxin in chemotactically activated neutrophils. Biomed Pharmacother 1987;41:349-354
10. Britigan BE, Rosen GM, Chai Y, Cohen MS. Do human neutrophils make hydroxyl radical? J Biol Chem 1986:261: 4426-4431
11. Lukey PT, Anderson R, Dippenaar UH. Benoxaprofen activates membrane-associated oxidative metabolism in human polymorphonuclear leucocytes by apparent modulation of protein kinase C. Br J Pharmacol 1988;93:289-294
12. Paul BB, Selvaraj RJ, Sbarra AJ. A sensitive assay method for peroxidases from various sources. J Reticuloendoth Soc 1978;23:407-410
13. Parry RM Jr, Chandan RC, Shahani KM. A rapid and sensitive assay of muramidase. Proc Soc Exp Biol Med 1965;119:384-386
14. Anderson R, Lukey P, Van Rensburg CV, Dippenaar U. Clofazimine-mediated regulation of human polymorphonuclear leukocyte migration by pro-oxidative inactivation of both leukoattractants and cellular migratory responsiveness. Int J Immunopharmacol 1986;6:605-620
15. Munson PI. LIGAND: A computerized analysis of ligand binding data. Meth Enzymol 1983;92:543-576
16. Dahlgren C, Aniansson H, Magnusson K. Pattern of formyl-methionyl-leucyl-phenylalanine-induced luminol and lucigenin-dependent chemiluminescence in human neutrophils. Infect Immun 1985;47:326-328
17. Tsien RY, Pozzan T, Rink TJ. Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator. J Cell Biol 1982;94:325-334
18. 2, but not protein kinase C, in the pro-oxidative interactions of clofazimine with human phagocytes. Biochem Pharmacol 1988;37:4635-4641
19. Babior BM. Oxidants from phagocytes: agents of defense and destruction. Blood 1984;64:959-966
20. Minkenberg I, Ferber E. Lucigenin-dependent chemilumines cence as a new assay for NADPH-oxidase activity in particulate fractions of human polymorphonuclear leukocytes. J Immunol Meth 1984;71:61-67
21. Hurst NP, French JK, Bell AL, Nuki G, O’Donnell ML, Betts WH, Cleland LG. Differential effects of mepacrine, chlo- roquine and hydroxy-chloroquine on superoxide anion generation, phospholipid methylation and arachidonic acid release by human blood monocytes. Biochem Pharmacol 1986;35:3083-3089
22. Prokesch RC, Hand WL. Antibiotic entry into human poly morphonuclear leukocytes. Antimicrob Agents Chemother 1982;21:373-380
23. Hand WL, King-Thompson N, Holman JW. Entry of rox-ythromycin (RU965), imipenem, cefotaxime, trimethoprim and metronidazole into human polymorphonuclear leukocytes. Antimicrob Agents Chemother 1987;31:1553-1557
24. Anderson R, Van Rensburg CEJ, Joone G, Lukey PT. An in-vitro comparison of the intraphagocytic bioactivity of erythromycin and roxithromycin. J Antimicrob Chemother 1987;20(Suppl B):57-68
25. Cox JA, Jeng AY, Sharkey NA, Blumberg PM, Tauber AI. Activation of the human neutrophil nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase by protein kinase C. J Clin Invest 1985;76:1932-1938
26. Schwalb G, Beyers AD, Anderson R, Nel AE. Promotion of DNA strand breaks in cocultured mononuclear leukocytes by protein kinase C-dependent prooxidative interactions of benoxaprofen, human polymorphonuclear leukocytes, and ultraviolet radiation. Cancer Res 1988;48:3094-3099
27. Clark RA, Leidal KG, Pearson DW, Nauseef WM. NADPH oxidase of human neutrophils: subcellular localization and characterization of an arachidonate-activatable superoxidegenerating system. J Biol Chem 1987;262:4065-4074
28. Curnutte JT, Kuver R, Scott PJ. Activation of neutrophil NADPH oxidase in a cell-free system: partial purification of components and characterization of the activation process. J Biol Chem 1987;262:5563-5569
29. Sakata A, Ida E, Tominaga M, Onoue K. Arachidonic acid acts as an intracellular activator of NADPH-oxidase in Fc receptor-mediated superoxide generation in macrophages. J Immunol 1987;138:4353-4359
30. Styrt B, Klemper MS. Inhibition of neutrophil oxidative me tabolism by lysosomotropic weak bases. Blood 1986;67: 334-342
31. Miyahara M, Watanabe S, Okimasu E, Utsumi K. Charge-dependent regulation of NADPH oxidase activity in guinea-pig polymorphonuclear leukocytes. Biochem Bio- phys Acta 1987;929:253-262
32. Fernandes AC, Anderson R, Theron AJ, Joone G, Van Rens- burg CEJ. Enhancement of human polymorphonuclear leukocyte motility by erythromycin in vitro and in vivo. S Afr Med J 1983;66:173-177
33. Prieto JP, Minguez F, Ortega P, Corrales I, Ledesma V. Comparative study of the effects of roxithromycin and other macrolides on polymorphonuclear white cells in vitro. Br J Clin Prac 1988;42(Suppl 55):38-39
34. Dalziel K, Dykes PJ, Marks R. The effect of tetracycline and erythromycin in a model of acne-type inflammation. Br J Exp Pathol 1987;68:67-70
35. Forsgren A, Schmeling D. Effect of antibiotics on chemotaxis of human leukocytes. Antimicrob Agents Chemother 1977;11:580-584
36. Esterly NB, Furey NL, Flanagan LE. The effect of antimicrobial agents on leukocyte chemotaxis. J Invest Dermatol 1978;70:51-55
37. Nelson S, Summer WR, Terry PB, Warr GA, Jakab GJ. Erythromycin-induced suppression of pulmonary antibacterial defenses. A potential mechanism of superinfection in the lung. Am Rev Respir Dis 1987;136:1207-1212
38. Hovi T, Josefsson K, Renkonen OV. Erythromycin absorption in healthy volunteers from single and multiple doses of enteric-coated pellets and tablets. Eur J Clin Pharmacol 1983;25:271-273
39. Puri SK, Lassman HB. Roxythromycin: a pharmacokinetic review of a macrolide. J Antimicrob Chemother 1987; 20(Suppl B):89-100