Sumatriptan (GR 43175) interacts selectively with 5-HT1B and 5-HT1D binding sites

European Journal of Pharmacology

Volumn 163, Issue 1, 1989, Pages 133-136

  Peroutka, Stephen J ^a   McCarthy, Bruce G ^a  

^a STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

5 HT1B binding sites; 5 HT1D binding sites; Sumatriptan (GR 43175)

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; BUTACLAMOL; CINANSERIN; DIAZEPAM; DIHYDROALPRENOLOL; FLUNITRAZEPAM; KETANSERIN; MESULERGINE; NEUROTRANSMITTER RECEPTOR; PRAZOSIN; PROPRANOLOL; QUINUCLIDINYL BENZILATE; QUIPAZINE; RADIOISOTOPE; RADIOLIGAND; RAUWOLSCINE; SCOPOLAMINE; SEROTONIN; SEROTONIN 1B RECEPTOR; SEROTONIN 1D RECEPTOR; SEROTONIN RECEPTOR; SPIPERONE; SUMATRIPTAN; SUMATRIPTAN SUCCINATE; TROPISETRON;

ANIMAL CELL; BRAIN; CATTLE; NONHUMAN; PRIORITY JOURNAL; RAT; SWINE;

ANIMAL; CATTLE; IN VITRO; INDOLES; RADIOLIGAND ASSAY; RATS; RECEPTORS, NEUROTRANSMITTER; RECEPTORS, SEROTONIN; SULFONAMIDES; SUMATRIPTAN; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; SWINE;

EID: 0024565401     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(89)90406-8     Document Type: Article

References (10)

1. 1-like receptor agonist, for the acute treatment of severe migraine
2. Selective vasoconstrictor action of GR 43175 on arteriovenous anastomoses in the anaesthetized cat
3. 3H-5-hydroxytryptamine binding site subtype in bovine brain membranes
4. 1A binding sites
5. 1B recognition sites
6. 1-like receptor in dog isolated saphenous vein
7. Mesulergine, a selective serotonin-2 ligand in the rat cortex, does not label these receptors in porcine and human cortex: Evidence for species differences in brain serotonin-2 receptors
8. 1C binding sites in rat frontal cortex
9. 1D receptor subtype is negatively coupled to adenylate cyclase in calf substantia nigra