Sensitivity to genotoxic effects of bleomycin in humans: Possible relationship to environmental carcinogenesis

International Journal of Cancer

Volumn 43, Issue 3, 1989, Pages 403-409

  Hsu, T C ^a   Johnston, Dennis A ^a   Cherry, Lorraine M ^a,b   Ramkissoon, Dindyal ^a,c   Schantz, Stimson P ^b   Jessup, John M ^a   Winn, Rodger J ^a   Shirley, Linda ^a   Furlong, Cynthia ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c Perceptive Scientific Instruments   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN;

CANCER PATIENT; CANCER RISK; CELL CULTURE; CHROMOSOME BREAKAGE; DRUG SENSITIVITY; ENVIRONMENT; GENOTOXICITY; HUMAN; HUMAN CELL; LYMPHOCYTE; PRIORITY JOURNAL;

ADULT; AGED; BLEOMYCIN; CHROMOSOME ABERRATIONS; DISEASE SUSCEPTIBILITY; ENVIRONMENTAL POLLUTANTS; HUMAN; MALE; MIDDLE AGE; MUTAGENICITY TESTS; MUTAGENS; NEOPLASMS; SMOKING; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0024563577     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.2910430310     Document Type: Article

References (33)

1. Xeroderma pigmentosum
2. Cell killing and mutagenesis in repair‐Defective human cells
3. Heterogeneous DNA damage and repair in the mammalian genome
4. Mechanisms of bleomycin action: in vitro studies
5. Altered DNA ligase I activity in Bloom's syndrome cells
6. Bleomycin‐Induced chromosome damage in lymphocytes of medullary thyroid carcinoma patients and their family members
7. Defective repair replications of DNA in xeroderma pigmentosum
8. X‐Ray induced breakage and rejoining of human interphase chromosomes
9. Sister chromatid exchanges and unscheduled DNA synthesis studies in a family with retinoblastoma
10. 2 chromatid radiosensitivity and susceptibility to cancer
11. DNA repair and its relationship to the origins of human cancer
12. Sensitivity to five mutagens in Fanconi's anemia as measured by the micronucleus method
13. Heterogeneity in chromosome damage and repair rates after bleomycin in ataxia telangiectasia cells
14. Genetic predisposition to cancer with special reference to mutagen sensitivity
15. A short‐Term cytogenetic test for genetic instability in humans
16. Differential mutagen susceptibility in cultured lymphocytes of normal individuals and cancer patients
17. Differential susceptibility to a mutagen among human individuals: synergistic effect on chromosome damage between bleomycin and aphidicolin
18. Single‐Strand scission and repair of DNA in mammalian cells by bleomycin
19. Mutation and cancer: statistical study of retinoblastoma
20. Genetic oncodemes and antioncogenes
21. Effect of pH on the bleomycin‐Induced DNA single‐Strand scission in L1210 cells and the relation to cell survival
22. Bleomycin causes release of nucleosomes from chromatin and chromosomes
23. Frequency of ultraviolet light induced mutation is higher in xeroderma pigmentosum variant cells
24. Unscheduled DNA synthesis, UV‐Induced chromosome aberrations and SV40 transformation in cultured cells from xeroderma pigmentosum
25. Strategies for controlling cancer through genetics: report of a workshop
26. 2 phase X‐Irradiation of cells from cancer‐Prone individuals implicates deficiency in DNA repair
27. Ataxia telangiectasia: an inherited human disorder involving hypersensitivity to ionizing radiation and related DNA‐Damaging chemicals
28. Reduced capacity for DNA repair synthesis in patients with or genetically predisposed to colorectal cancer
29. Repair deficient human disorders and cancer
30. Evidence that xeroderma pigmentosum cells do not perform the first step in the repair of ultraviolet damage to their DNA
31. Structural alterations of DNA ligase 1 in Bloom syndrome