Differential induction of fetal mouse liver and lung cytochromes p-450 by β-naphthoflavone and 3-methylcholanthrene

Carcinogenesis

Volumn 10, Issue 5, 1989, Pages 875-883

  Park, Sang S ^a   Miller, Mark Steven ^b   Jones, Ann B ^b   Chauhan, Dharam P ^b   Anderson, Lucy M ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b Laboratory of Comparative Carcinogenesis   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLCHOLANTHRENE; BETA NAPHTHOFLAVONE; CYTOCHROME P450;

ANIMAL EXPERIMENT; FEMALE; FETUS; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; TRANSPLACENTAL CARCINOGENESIS;

ANIMAL; ARYL HYDROCARBON HYDROXYLASES; BENZOFLAVONES; BETA-NAPHTHOFLAVONE; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; FEMALE; FETUS; FLAVONES; LIVER; LUNG; MALE; METHYLCHOLANTHRENE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; PREGNANCY; REFERENCE VALUES; RNA;

EID: 0024558427     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/10.5.875     Document Type: Article

References (51)

1. Miller, E.C. (1978) Some current perspectives on chemical carcinogenesis in humans and experimental animals: presidential address. Cancer Res., 38, 1479–1496.
2. Pelkonen, O. and Nebert, D.W. (1982) Metabolism of polycyclic aromatic hydrocaibons: etiologic role in carcinogenesis. Pharmacol. Rev., 34, 189–222.
3. Conney, A.H. (1967) Pharmacological implications of microsomal enzyme induction. Pharmacol. Rev., 19, 317–366.
4. Conney.A.H. (1982) Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G.H.A. Clowes Memorial Lecture. Cancer Res., 42, 4875–4917.
5. Nebert, D.W., Eisen, H.J., Negishi, M., Lang, M.A., Hjelmeland, L.M. and Okey, A.B. (1981) Genetic mechanisms controlling the induction of polysubstrale monooxygenase (P-450) activities. Annu. Rev. Pharmacol. Toxicol., 21, 431–462.
6. Nebert, D.W., Adesnik, M., Coon, M.J., Estabrook, R.W., Gonzalez, F.J., Guengerich, F.P., Gunsalus, I.C., Johnson, E.F., Kemper, B., Levin, W., Phillips, I.R., Sato, R. and Waterman, M.R. (1987) The P-450 gene superfamily: recommended nomenclature. DNA, 6, 1–11.
7. Rice, J.M. (1979) Perinatal period and pregnancy: intervals of high risk for chemical carcinogens. Environ. Health Perspect., 29, 23–27.
8. Anderson, L.M., Jones, A.B., Riggs, C.W. and Ohshima, M. (1985) Fetal mouse susceptibility to transplacental lung and liver carcinogenesis by 3-methylcholanthrene: positive correlation with responsiveness to inducers of aromatic hydrocarbon metabolism. Carcinogenesis, 6, 1389–1393.
9. George, J.D. and Manson, J.M. (1986) Strain-dependent differences in the metabolism of 3-methylcholanthrene by maternal, placental and fetal tissues of C57BL/6J and DBA/2J mice. Cancer Res., 46, 5671–5675.
10. b allele following transplacental exposure to 3-methylcholanthrene. Toxicol. Appl. Pharmacol., 72, 417–426.
11. d allele following in utero exposure to 3-methylcholanthrene. Toxicol. Appl. Pharmacol., 72, 427–439.
12. Legraverend, C., Guenthner, T.M. and Nebert, D.W. (1984) Importance of the route of administration for genetic differences in benzo[a]pyrene-induced in utero toxicity and teratogenicity. Teratology, 29, 35–47.
13. Shum, S., Jensen, N.M. and Nebert, D.W. (1979) The murine Ah locus: in utero toxicity and teratogenesis associated with genetic differences in benzo[a]pyrene metabolism. Teratology, 20, 365–376.
14. Gielen, J.E., Goujon, F.M. and Nebert, D.W. (1972) Genetic regulation of aryl hydrocarbon hydroxylase induction. Simple Mendelian expression in mouse tissues in vivo. J. Biol. Chem., 247, 1125–1137.
15. Thomas, P.E., Kouri.R.E. and Hutton, J.J. (1972) The genetics of aryl hydrocarbon hydroxylase induction in mice: a single gene difference between C57BL/6J and DBA/2J. Biochem. Gen., 6, 157–168.
16. Pelkonen, O. (1985) Fetoplacental biochemistry—xenobiotic metabolism and pharmacokinetics. In Hemminki, K., Sorsa.M. and Vainio, H. (eds), Occupational Hazards and Reproduction, Hemisphere Publishing Corp., Washington, pp. 113–126.
17. Nebert, D.W. and Gelboin, H.V. (1969) The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains and developmental and hormonal states. Arch. Biochem. Biophys., 134, 76–89.
18. Nebert, D.W. and Gielen, J.E. (1972) Genetic regulation of aiyl hydrocarbon hydroxylase induction in the mouse. Fed. Proc., 31, 1315–1325.
19. Guenthner, T.M. and Nebert, D.W. (1978) Evidence in rat and mouse liver for temporal control of two forms of cytochrome P-450 inducible by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin. Eur. J. Biochem., 91, 449–456.
20. 1-450 genomic gene and differential response to the inducers 3-methylcholanthrene and isosafrole. Eur. J. Biochem., 134, 13–18.
21. 1-450 gene during differentiation without foreign chemical stimulation. J. Exp. Pathol., 3, 61–74.
22. 3-450 cDNA nucleotide and amino acid sequences. J. Biol. Chem., 259, 10705–10713.
23. 3-450 genes. J. Biol. Chem., 260, 5040–5049.
24. Jannetti, R.A. and Anderson, L.M. (1981) Dimethylnitrosamine demethylase activity in fetal, suckling and maternal mouse liver and its transplacental and transmammary induction by polychlorinated biphenyls. J. Natl. Cancer Inst., 67, 461–466.
25. Nebert, D.W and Gelboin, H.V. (1968) Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. I. Assay and properties of induced enzyme. J. Biol. Chem., 243, 6242–6249.
26. Nebert, D.W. (1978) Genetic differences in microsoma] electron transport: the Ah locus. Methods Enzymol., 52, 226–240.
27. Park, S.S., Fujino, T., West, D., Guengerich, F.P. and Gelboin.H.V. (1982) Monoclonal antibodies that inhibit enzyme activity of 3-methylcholanthrene- induced cytochrome P-450. Cancer Res., 42, 1798–1808.
28. Fujino, T., West, D., Park, S.S. and Gelboin, H V. (1984) Monoclonal antibody- directed phenotyping of cytochrome P-450-dependent aryl hydrocarbon hydroxylase and 7-ethoxycoumarin deethylase in mammalian tissues. J. Biol. Chem., 259, 9044–9050.
29. Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randall, R.J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193, 265–275.
30. MacDonald, R.J., Swift, G.H., Przybyla, A.E. and Chirgwin, J.M. (1987) Isolation of RNA using guanidinium salts. Methods Enzymol., 152, 219–227.
31. Glišin, V., Crkvenjakov, R. and Byus, C. (1974) Ribonucleic acid isolated by cesium chloride centrifugation. Biochemistry, 13, 2633-2637.
32. Thomas, P.S. (1980) Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc. Natl. Acad. Sci. USA, 77, 5201–5205.
33. Thomas, P.S. (1983) Hybridization of denatured RNA transferred or dotted to nitrocellulose paper. Methods Enzymol., 100, 255–266.
34. Feinberg, A.P. and Vogelstein.B. (1983) A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem, 132, 6–13.
35. Feinberg, A.P. and Vogelstein.B. (1984) Addendum: a technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem., 137, 266–267.
36. Steel, R.G.D. and Torrie, J.H. (1980) Principles and procedures of statistics. A Biometrical Approach. McGraw-Hill Book Co., New York, 2nd edn, pp. 187–188.
37. Hollander, M. and Wolfe, D.A. (1973) Nonparametric Statistical Methods. John Wiley and Sons, New York, pp. 120–123.
38. Snedecor, G.W. and Cochran, W.G. (1967) Statistical Methods. The Iowa State University Press, Ames, Iowa, 6th edn, pp. 114–119.
39. 3-450 mRNA levels by 3-methylcholanthrene. Mol. Pharmacol., 26, 117–121.
40. 1-450 DNA. Biochem. Biophys. Res. Commun., 104, 641–648.
41. Kawajiri, K., Gotoh, O., Tagashira, Y., Sogawa, K. and Fujii-Kuriyama, Y. (1984) Titration of mRNAs for cytochrome P-450c and P-450d under drug- inductive conditions in rat livers by their specific probes of cloned DNAs. J. Biol., Chem, 259, 10145–10149.
42. Bresnick, E., Brosseau, M., Levin, W., Reik, L., Ryan, D.E. and Thomas, P.E. (1981) Administration of 3-methylcholanthrene to rats increases the specific hybridizable mRNA coding for cytochrome P-450c. Proc. Natl. Acad. Sci. USA. 78, 4083–4087.
43. Boobis, A.R., Nebert, D.W. and Felton, J.S. (1987) Comparison ofβ-naphthoflavone and 3-methylcholanthrene as inducers of hepatic cytochrome(s) P-448 and aryl hydrocarbon (benzo[a]pyrene) hydroxylase activity. Mol. Pharmacol., 13, 259–268.
44. Bigelow, S.W. and Nebert, D.W. (1982) The Ah regulatory gene product. Survey of nineteen polycyclic aromatic compounds’ and fifteen benzo[a]pynene metabolites’ capacity to bind to the cytosolic receptor. Toxicol. Lett., 10, 109–118.
45. Gasiewicz, T.A. and Rucci, G. (1984) Cytosolic receptor for 2, 3, 7, 8-tetra- chlorodibenzo-p-dioxin. Evidence for a homologous nature among various mammalian species. Mol. Pharmacol., 26, 90–98.
46. Collins, S. and Marietta, M.A. (1984) Carcinogen-binding proteins. High- affimty binding sites for benzo[a]pyrene in mouse liver distinct from the Ah receptor. Mol. Pharmacol., 26, 353–359.
47. Tukey, R.H., Negishi, M. and Nebert, D.W. (1982) Quantitation of hepatic cytochrome P1-450 mRNA with the use of a cloned DNA probe. Effects of various P-450 inducers in C57BL/6N and DBA/2N mice. Mol., Pharmacol., 779–786.
48. Okey, A.B., Bondy, G.P., Mason, M.E., Kahl, G.F., Eisen, H.J., Guenthner, T.M. and Nebert, D.W. (1979) Regulatory gene product of the Ah locus. Characterization of the cytosolic inducer—receptor complex and evidence for its nuclear translocation. J. Biol. Chem., 254, 11636–11648.
49. Giachelli, C.M. and Omiecinski, C.J. (1987) Developmental regulation of cytochrome P-450 genes in the rat. Mol. Pharmacol., 31, 477–484.
50. Shiverick, K.T., Kvello-Stenstrom, A.G., Donnelly, W.H., Salhab, A.S., Goldstein, J.A. and James, M.O. (1986) Induction of cytochrome P-450c in hematopoietic cells of fetal liver. Biochem. Biophys. Res. Commun., 141, 299–305.
51. Cresteil, T., Beaune, P., Celier, C., Leroux, J.P. and Guengerich, F.P. (1986) Cytochrome P-450 isozyme content and monooxygenase activities in rat liver: effect of ontogenesis and pretreatment by phenobarbital and 3-methylcholan- threne. J. Pharmacol. Exp. Ther., 236, 269–276.