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Volumn 54, Issue 8, 1989, Pages 1792-1795

Simplified Analogues of the Antimalarial Artemisinin: Synthesis of 6,9-Desmethylartemisinin

Author keywords

[No Author keywords available]

Indexed keywords

6,9 DINORARTEMISININ; UNCLASSIFIED DRUG;

EID: 0024555990     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo00269a009     Document Type: Article
Times cited : (65)

References (12)
  • 1
    • 0021948029 scopus 로고
    • Klayman, D. L. Science 1985, 228, 1049.
    • (1985) Science , vol.228 , pp. 1049
    • Klayman, D.1
  • 2
    • 0001500832 scopus 로고
    • Synthetic approaches to artemisinin: (a) Jung, M.; ElSohly, H.; Croom, E.; McPhail, A.; McPhail, D. J. Org. Chem. 1986, 51, 5417. (b) Clark, G.; Nidado, M.; Fair, C.; Lin, J. J. Org. Chem. 1985, 50,1494. Total syntheses: (c) Zhou, W. Pure Appl. Chem. 1986,58, 817. (d) Xing-xiang, X.; Zhu, J.; Da-zhong, H.; Zhou, W. Tetrahedron 1986, 41, 819. (e) Schmid, G.; Hofheinz, W. J. Am. Chem. Soc. 1983, 105, 624. Analogues of artemisinin: (f) Brossi, A.; Venugopalan, B.; Dominguez Gerpe, L.; Yeh, H. J. C.; Flippen-Anderson, J. L.; Buchs, P.; Luo, X. D.; Milhous, W.; Peters. W. J. Med. Chem. 1988. 31. 645.
    • (1986) J. Org. Chem , vol.51 , pp. 5417
    • Jung, M.1    ElSohly, H.2    Croom, E.3    McPhail, A.4    McPhail, D.5
  • 6
    • 0006460803 scopus 로고
    • The possibility of trans or “inside-outside” stereoisomers in such bicyclic bridging ketones (albeit remote in our situation) has recently been addressed. See: (b) Winkler, J. D.; Henegar, K. E.; Willard, P. G. J. Am. Chem. Soc. 1987,109, 2850. (c) Funk, R. L.; Olmstead, T. A.: Parvez. M. J. Am. Chem. Soc. 1988. 110. 3298.
    • The possibility of trans or “inside-outside” stereoisomers in such bicyclic bridging ketones (albeit remote in our situation) has recently been addressed. See: (a) Winkler, J. D.; Hey, J. P.; Willard, P. G. J. Am. Chem. Soc. 1986,108, 6425. (b) Winkler, J. D.; Henegar, K. E.; Willard, P. G. J. Am. Chem. Soc. 1987,109, 2850. (c) Funk, R. L.; Olmstead, T. A.: Parvez. M. J. Am. Chem. Soc. 1988. 110. 3298.
    • (1986) J. Am. Chem. Soc. , vol.108 , pp. 6425
    • Winkler, J.D.1    Hey, J.P.2    Willard, P.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.