Combination therapy with gold and hydroxychloroquine in rheumatoid arthritis: A prospective, randomized, placebo-controlled study

Rheumatology

Volumn 28, Issue 2, 1989, Pages 128-133

  Scott, D L ^a   Dawes, P T ^b   Tunn, E ^c   Fowler, P D ^b   Shadforth, M F ^b   Fisher, J ^b   Clarke, S ^b   Collins, M ^b   Jones, P ^d   Popert, A J ^d   Bacon, P A ^c  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^b Staffordshire Rheumatology Centre   (United Kingdom)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^d Highfield Hospital ^*  (United Kingdom)

Author keywords

Antimalarials; Rheumatoid arthritis; Sodium aurothiomalate; Treatment

Indexed keywords

AUROTHIOMALATE; HYDROXYCHLOROQUINE;

ADULT; DISEASE ACTIVITY; FEMALE; HEPATITIS; HUMAN; INTRAMUSCULAR DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; MOUTH ULCER; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROTEINURIA; RASH; RHEUMATOID ARTHRITIS; THROMBOCYTOPENIA;

ADULT; AGED; ARTHRITIS, RHEUMATOID; CLINICAL TRIALS; DRUG THERAPY, COMBINATION; GOLD; HUMAN; HYDROXYCHLOROQUINE; MIDDLE AGE; PAIN; PLACEBOS; PROSPECTIVE STUDIES; RANDOM ALLOCATION; SEVERITY OF ILLNESS INDEX; SUPPORT, NON-U.S. GOV'T; TIME FACTORS;

EID: 0024549810     PISSN: 14620324     EISSN: None     Source Type: Journal    
DOI: 10.1093/rheumatology/28.2.128     Document Type: Article

References (27)

1. Ehrlich GE. Heroic treatment for non-malig nant disease. JAMA 1982;248:1744-5.
2. Huskisson EC. Combination chemotherapy in rheumatoid arthritis. Br J Rheumatol 1987; 26:243-4.
3. Dawes PT, Tunn EJ, Fowler PD, Scott DL. Combination therapy in rheumatoid arthritis. Br J Clin Pract 1987;41(Suppl 52):28-35.
4. McCarty DJ, Carrera GF. Treatment of intractable rheumatoid arthritis with combined cyclophosphamide, azathioprine and hydroxychloroquine. JAMA 1982;248: 1718-23.
5. Csuka M, Carrera GF, McCarthy DJ. Treat ment of intractable rheumatoid arthritis with combined cyclophosphamide, azathioprine and hydroxychloroquine. A follow-up study. JAMA 1986;255:2315-19.
6. Martin M, Dixon J, Hickling P, Bird H, Gold ing J, Wright V. A combination of penicillamine and hydroxychloroquine for the treatment of rheumatoid arthritis. Ann Rheum Dis 1982;41:208.
7. Bitter T. Combined disease-modifying chemo therapy for intractable rheumatoid arthritis. Rheum Dis 1984;10:417-28.
8. Dawes PT, Sheeran TP, Fowler PD, Shadforth MF. Improving the response to gold or d-penicillamine by addition of sul-phasalazine—a pilot study of 25 patients with rheumatoid arthritis. Clin Exp Rheumatol 1987;5:151-3.
9. Farr M, Kitas GD, Bacon PA. Combination therapy in rheumatoid arthritis. Br J Rheumatol 1988;27:73-4.
10. Taggart AJ, Jill J, Astbury C, Dixon JS, Bird HA, Wright V. Sulphasalazine alone or in combination with D-penicillamine in rheumatoid arthritis. Br J Rheumatol 1987;26: 32-6.
11. Bunch TW, O’Duffy JD, Tompkins RB, O’Falon WM. Controlled trial of hydroxychloroquine and D-penicillamine singly and in combination in the treatment of rheumatoid arthritis. Arthritis Rheum 1984;27: 267-76.
12. Gibson T, Emery P, Armstrong RD, Crisp AJ, Panayi GS. Combined D-penicillamine and chloroquine treatment of rheumatoid arthritis—a comparative study. Br J Rheumatol 1987;26:279-84.
13. Scott DL, Coulton BL, Chapman JH, Bacon PA, Popert AJ. The long term effects of treating rheumatoid arthritis. J Roy Coll Phys 1983;17:79-85.
14. Ritchie D, Boyle JA, Mclnnes JM, etal. Clini cal studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis. Q J Med 1968;37: 393-406.
15. Dawes PT, Fowler PD, Collins M, Shadforth MF. Evaluation of an inflammatory index for rheumatoid arthritis. Br J Rheumatol 1986; 25 (Suppl 1):30.
16. Larsen A, Dale K, Eck M. Radiographic eval uation of rheumatoid arthritis and related conditions by standard reference films. Acta Radiol Stockholm 1977;18:481-91.
17. Research Sub-committee of the Empire Rheu matism Council. Gold therapy in rheumatoid arthritis. Report of a multicentre controlled trial. Ann Rheum Dis 1960;19: 95-117.
18. Co-operating Clinics of the American Rheu matism Association. A controlled trial of gold salt therapy in rheumatoid arthritis. Arthritis Rheum 1973;16:353-8.
19. Sigler JW, Bluhm GB, Duncan H, Sharp JT, Ensign DC, McCrann WR. Gold salts in the treatment of rheumatoid arthritis. A doubleblind study. Ann Intern Med 1974;80:21-6.
20. Schwarzer CHW, Arnold MH, Kelly D, el o/.The cycling of combination antirheumatic drug therapy in rheumatoid arthritis. Br J Rheumatol 1990;29:445-50.
21. Pullar T, Capell HA. Selection of suitable patients for second line therapy in rheumatoid arthritis. Br J Rheumatol 1986;25:276-81.
22. Borg G, Allander E, Lund B, Berg E, Brodin U. Auranofin improves outcome in early rheumatoid arthritis: results from a two year double blind, placebo controlled studv. J Rheumatol 1988;15:1747-54.
23. Van der Heijde DMFM, Van Riel PL, Nuver-swart HH, Van de Putte LBA. Sulphasalazine versus hydroxychloroquine in rheumatoid arthritis: three year follow up Lancet 1990;1:539.
24. Pullar T. Disease modifying drugs for rheumatoid arthritis: yesterday’s treatment today or today’s treatment tomorrow? Br J Clin Pharmacol 1990;30:501-10.
25. Neumann V, Hopkins R, Dixon J, Watkins A, Bird H, Wright V. Combination therapy with pulsed methylprednisolone in rheumatoid arthritis. Ann Rheum Dis 1980;44:747-51.
26. Hansen TM, Kryger P, Elling H, et al. Double blind placebo controlled trial of pulse treatment with methylprednisolone combined with disease modifying drugs in rheumatoid arthritis. Br Med J 1990;301:268-70.
27. Healy LA, Wilske KR. Reforming the pyramid. A plan for treating rheumatoid arthritis in the 1990s. Rheum Dis Cltns North Am 1989;15:615-19.