Complement activation in amyloid plaques in Alzheimer's dementia

Virchows Archiv B Cell Pathology Including Molecular Pathology

Volumn 56, Issue 1, 1988, Pages 259-262

  Eikelenboom, P ^a   Hack, C E ^b   Rozemuller, J M ^a   Stam, F C ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Alzheimer's dementia; Amyloid plaques; Complement activation

Indexed keywords

AMYLOID;

ALZHEIMER DISEASE; AUTOPSY; COMPLEMENT ACTIVATION; CYTOLOGY; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; COMPLEMENT ACTIVATION; HUMAN; IMMUNOENZYME TECHNIQUES; IMMUNOHISTOCHEMISTRY; MIDDLE AGE;

EID: 0024543574     PISSN: 00426431     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02890024     Document Type: Article

References (24)

1. Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer’s disease
2. Blood-brain barrier in Alzheimer’s dementia and in nondemented elderly
3. Immunoglobulins and complement factors in senile plaques: an immunohistoperoxidase study
4. An immunohistochemical study in cerebrovascular and senile plaque amyloid in Alzheimer’s dementia
5. No evidence for involvement of plasmaproteins or blood-borne cells in amyloid plaque formation in scrapie-affected mice
6. Alzheimer’s disease and Down’s syndrome: sharing of a unique cerebrovascular amyloid fibril protein
7. Disruption of the internal thioester bond in the third component of complement (C3) results in the exposure of neodeterminants also present on activation products of C3
8. Immuno-electron-microscopic localisation of complements in amyloid fibrils of senile plaques
9. The precursor of Alzheimer’s disease amyloid A4 protein resembles a cell-surface receptor
10. Novel precursor of Alzheimer’s disease amyloid protein shows protease inhibitory activity
11. Breakdown of C3 after complement activation. Identification of a new fragment, C3g, using monoclconal antibodies
12. Amyloid plaque core protein in Alzheimer disease and Down syndrome
13. Molecular biology and chemistry of the alternative pathway of complement
14. Inactivation of C1 inhibitor by proteases: demonstration by a monoclonal antibody of a neodeterminant on inactivated, non-complexed C1 inhibitor
15. Relation of a putative thioesterbond in C3 to activation of the alternative pathway and the binding of C3b to biological targets of complement
16. Formation of the initial C3 convertase of the alternative complement pathway. Acquisition of C3b-like activities by spontaneous hydrolysis of the putative thioester in native C3
17. New immunological findings in senile dementia
18. Immunological markers and neuropathological lesions in Alzheimer’s disease
19. A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors
20. On the binding of Congo red by amyloid
21. Immunological study of cerebral senile amyloid (congophilic angiopathy and senile plaques)
22. Detection of a neoantigen on human C3bi and C3d by a monoclonal antibody
23. Protease inhibitor domain encoded by an amyloid precursor mRNA associated with Alzheimer’s disease
24. Active disassembly of the first complement component, C1, by Cl inactivator