Studies on the mechanism of reduction of azo dye carcinogens by rat liver microsomal cytochrome P-450

Chemico-Biological Interactions

Volumn 69, Issue 1, 1989, Pages 61-71

  Zbaida, Shmuel ^a   Stoddart, Albert M ^a   Levine, Walter G ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Azo dye carcinogens; Cytochrome P 450; Microsomes; Reduction mechanisms

Indexed keywords

AZO DYE; CARCINOGEN; CYTOCHROME P450;

ANIMAL CELL; ANIMAL EXPERIMENT; LIVER MICROSOME; NONHUMAN; PRIORITY JOURNAL; RAT; REDUCTION;

ANIMAL; AZO COMPOUNDS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; IN VITRO; KINETICS; MALE; MICROSOMES, LIVER; OXIDATION-REDUCTION; RATS; SPECTRUM ANALYSIS; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0024541421     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/0009-2797(89)90099-9     Document Type: Article

References (25)

1. Teratology studies on food colourings Part 1, Embryotoxicity of amaranth (FD and C red No. 2) in rats
2. Azo reduction of trypan blue to a known carcinogen by a cell free extract of a human intestinal anerobe
3. Carcinogenic chemicals in food as an environmental issue
4. Studies on the mechanism of action of mammalian hepatic azoreductase I, Azoreductase activity of reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase
5. Rat liver cytosolic azoreductase, electron transport properties and the mechanism of dicumarol inhibition of the purified enzyme
6. Reduction of water-soluble azo dyes by intestinal bacteria
7. Liver microsomal cytochrome P-450 and azoreductase activity
8. Inhibition of azoreductase activity by antibodies against cytochrome P-450 and P-448
9. On the protective action of certain polycyclic aromatic hydrocarbons against carcinogenesis by aminoazo dyes and 2-acetylaminofluorene
10. The role of ethyl and fluorine substitution in the 4′-position of NN-diethyl-4-aminoazobenzene mutagenicity and azo reduction
11. The possible role of azoreduction in the bacterial mutagenicity of 4-dimethylaminoazobenzene (DAB) and 2 of its analogues (6BT and SI)
12. Metabolism of chemical carcinogens
13. 4-Dimethylaminoazobenzenes: carcinogenicities and reduction cleavage by microsomal azo reductase
14. Electron spectra of azobenzene carboxylic acid arylamides. I. Electron spectra of azobenzene-4-carboxylic and trans-4-nitro azobenzene-4′-carboxylic acid arylamides
15. 1HNMR and 1R spectra of some para-substituted azobenzenes
16. Zur Umwandlung von 4-dimethylamino-azobenzol in rattenkörper
17. Regulation by thiol environment of the N-demethylation and ring hydroxylation of N,N-diemthyl-4-aminoazobenzene (DAB) by rat liver microsomes
18. A sensitive, fluorometric method for the assay of microsomal hydroxylase: N-demethylation of p-chloro-N-methylaniline
19. Reduction of aromatic nitro-compounds by sodium borohydride catalysed by palladised charcoal
20. Polarographic and coulometric study of p-dimethylaminoazobenzene
21. Azoreduction of N,N-dimethyl-4-aminoazobenzene (DAB) by rat hepatic microsomes, selective induction by clofibrate
22. Mechanism of azoreduction of dimethylaminoazobenzene by rat liver NADPH-cytochrome P-450 reductase and partially purified cytochrome P-450. Oxygen and carbon monoxide sensitivity and stimulation by FAD and FMN
23. Azoreductase activity of Sprague Dawly and Wistar-derived rats towards both carcinoginic and non-carcinogenic analogues of 4-dimethylaminophenylazobenzene (DAB)
24. Mechanisms of inhibition of cytochrome P-450-mediated drug oxidation by therapeutic agents