Microenvironmental pH control of drug dissolution

International Journal of Pharmaceutics

Volumn 50, Issue 3, 1989, Pages 223-232

  Doherty, Chris ^a   York, Peter ^a  

^a Department of Pharmaceutical Technology Bradford University BradfordUK ^*

Author keywords

Buffered formulation; Dissolution; Frusemide; Microenvironmental pH control; Polyvinylpyrrolidone; Solid dispersion

Indexed keywords

BUFFER; FUROSEMIDE; POVIDONE;

DISPERSION; DISSOLUTION; DRUG SOLUBILITY; NONHUMAN; PH; PRIORITY JOURNAL;

EID: 0024536377     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(89)90126-9     Document Type: Article

References (19)

1. Pharmaceutical applications of solid dispersion systems
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4. Factors involved in quantitative X-ray analysis of solid dispersions
5. Investigation of drug release from solids. II. Theoretical and experimental study of influences of bases and buffers on rates of dissolution of acidic solids
6. Solubility and dissolution rates in reactive media
7. Dissolution kinetics of a weak acid, 1,1-hexamethylene p-tolylsulfonylsemicarbazide, and its sodium salt
8. Dissolution of aspirin from tablets containing various buffering agents
9. Development of in-vitro dissolution tests which correlate quantitatively with dissolution rate limited drug absorption in man
10. Dissolution kinetics of carboxylic acids. I. Effect of pH under unbuffered conditions
11. The rate of solution of substances in their own solutions
12. Effect of diffusion layer pH and solubility on the dissolution rate of pharmaceutical acids and their sodium salts. II. Salicylic acid, theophylline and benzoic acid
13. The solution process