Cromakalim, nicorandil and pinacidil: Novel drugs which open potassium channels in smooth muscle

General Pharmacology

Volumn 20, Issue 1, 1989, Pages 1-9

  Hamilton, T C ^a   Weston, A H ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DIAMINOPYRIDINE; 4 AMINOPYRIDINE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CROMAKALIM; NICORANDIL; PINACIDIL; POTASSIUM CHLORIDE; PROCAINE; TETRYLAMMONIUM;

ANGINA PECTORIS; ASTHMA; ELECTROPHYSIOLOGY; HUMAN; HYPERTENSION; NONHUMAN; POTASSIUM CHANNEL; PRIORITY JOURNAL; RABBIT; RAT; REVIEW; SMOOTH MUSCLE; SMOOTH MUSCLE FIBER MEMBRANE POTENTIAL; VASCULAR SMOOTH MUSCLE;

ANIMAL; GUANIDINES; HUMAN; NIACINAMIDE; NICORANDIL; PINACIDIL; POTASSIUM CHANNELS;

EID: 0024534172     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/0306-3623(89)90052-9     Document Type: Short Survey

References (96)

1. Nicorandil attenuates myocardial acidosis during coronary occlusion in dogs
2. Pinacidil: summary of basic pharmacology and therapeutic applications
3. Electrical and mechanical effects of BRL 34915 in guinea-pig isolated trachealis
4. The relaxant action of nicorandil in guinea-pig isolated trachealis
5. The effect of the novel antihypertensive agent BRL 34915 on the nutritional blood flow of rat chronically ischaemic muscle
6. Effects of nicorandil on rest and effort angina unresponsive to combination therapy with a calcium antagonist and oral nitrate
7. N″-cyano-N-4-pyridyl-N′-1,2,2-trimethylpropyl-guanidine monohydrate (P1134): a new, potent vasodilator
8. 2H-1-benzopyrans
9. 2H-benzopyran-3-ols as antihypertensive agents
10. Inhibition of histamine induced bronchoconstriction in normal healthy volunteers by a potassium channel activator, BRL 34915
11. Effects of BRL 34915 on membrane currents recorded from single smooth muscle cells from rabbit portal vein
12. Controlled comparison of the pharmacodynamic effects of nicorandil (SG-75) and isosorbide dinitrate in man
13. The mechanism of action of Ba and TEA on single Ca activated K-channels in arterial and intestinal smooth muscle cell membranes
14. Calcium-activated potassium channels in single smooth muscle cells of rabbit jejunum and guinea-pig mesenteric artery
15. 42K efflux in rabbit and guinea-pig arterial muscle
16. Mechanisms of action of noradrenaline and carbachol on smooth muscle of guinea-pig anterior mesenteric artery
17. Evidence that the mechanism of the inhibitory action of pinacidil in rat and guinea-pig smooth muscle differs from that of glyceryl trinitrate
18. Stereospecific mechanism of action of the antihypertensive agent BRL 34915
19. BRL 34915, a novel antihypertensive agent: comparison of effects on blood pressure and other haemodynamic parameters with those of nifedipine in animal models
20. Reversal of agonist-induced bronchoconstriction in the guinea-pig by the potassium channel activator BRL 34915
21. Catecholamine action on smooth muscle
22. Electrophysiological effects of the antihypertensive BRL 34915 on guinea-pig papillary muscle
23. Anti-spasmogenic and spasmolytic effects of BRL 34915: a comparison with nifedipine and nicorandil
24. Pinacidil monohydrate—a novel vasodilator
25. Comparison of the effects of pinacidil and its metabolite, pinacidil-N-oxide, in isolated smooth and cardiac muscle
26. BRL 34915 induced potassium channel activation in rabbit isolated mesenteric artery is not calcium dependent
27. Specificity of action of the novel antihypertensive agent, BRL 34915, as a potassium channel activator: comparison with nicorandil
28. Similarities in the mechanism of action of the two new vasodilator drugs, pinacidil and BRL 34915
29. Vasodilating actions of 2-nicotinamidoethyl nitrate on porcine and guinea-pig coronary arteries
30. Clinical Pharmacology of Pinacidil, A Prototype for Drugs That Affect Potassium Channels
31. Evidence for blood vessel selectivity of BRL 34915
32. BRL 34915, a novel antihypertensive agent with potassium channel activating properties
33. Comparison of the effects of BRL 34915 and verapamil on electrical and mechanical activity in rat portal vein
34. Effects of nicorandil on exercise tolerance in patients with stable effort angina: a double blind study
35. 86Rb fluxes and membrane potential in pancreatic β cells
36. Nitrendipine Inhibition of Calcium Current in Rat Vascular Muscle Cells
37. Modifiers of gating
38. Assessing calcium antagonism on vascular smooth muscle: a comparison of three methods
39. The relaxant action of BRL 34915 in rat uterus
40. Cyclic GMP on possible mediator of coronary arterial relaxation by nicorandil (SG-75)
41. BRL 34915 induced potassium channel activation: dependence on calcium ions for closing
42. The effect of tetraethylammonium chloride on potassium permeability in the smooth muscle cell membrane of canine trachea
43. Effects of SG-75 (nicorandil) on electrical activity of canine cardiac purkinje fibers: possible increase in potassium conductance
44. Two Ca-dependent K-channels classified by the application of tetraethylammonium distribute to smooth muscle membranes of the rabbit portal vein
45. +-channel in the smooth muscle membrane of single cells dispersed from the rabbit portal vein
46. The effects of 2-nicotinamidoethyl nitrate on smooth muscle cells of the dog mesenteric artery and trachea
47. Effects of 2-nicotinamidoethylnitrate (nicorandil: SG-75) and its derivatives on smooth muscle cells of the canine mesenteric artery
48. Effects of sodium nitroprusside on smooth muscle cells of rabbit pulmonary artery and portal vein
49. Effects of 2-nicotinamidoethyl nitrate on smooth muscle cells and on adrenergic transmission in the guinea-pig and porcine mesenteric arteries
50. Tetraethylammonium induced coronary spasm in isolated perfused rabbit heart: a hypothesis for the mechanism of coronary spasm
51. The potassium current activated by 2-nicotinamidoethyl nitrate (nicorandi) in single ventricular cells of guinea pigs
52. Actions of nitroglycerine on smooth muscle cells of the guinea-pig and rat portal veins
53. Effects of 2-nicotinamidoethyl nitrate on smooth muscle cells of the guinea-pig mesenteric and portal veins
54. Effects of pinacidil on serotonin-induced contractions and cyclic nucleotide levels in isolated rat aorta: comparison with nitroglycerin, minoxidil and hydralazine
55. Effectiveness of nicorandil in the preservation of myocardium stressed by transient ischemia and its influence on cardiac metabolism during coronary artery occlusion with subsequent reperfusion: a comparison with isosorbide dinitrate
56. 86Rb efflux in rabbit tonic vascular smooth muscle
57. 86Rb efflux in rabbit tonic vascular smooth muscle
58. Comparison of development of tolerance between nicorandil and nitroglycerin in anaesthetized, open-chest dogs
59. Determination of relative spin concentration in some high-spin ferric proteins using E/D-distribution in electron paramagnetic resonance simulations
60. Effects of nicorandil, a new antianginal agent, and nifedipine on collateral blood flow in a chronic coronary occlusion model
61. Cromakalim, a potassium channel activator: a comparison of its cardiovascular haemodynamic profile and tissue specificity with those of pinacidil and nicorandil.
62. + channel agonist to produce vasodilation
63. Action of quinidine and apamin on after hyperpolarization of the spike in circular smooth muscle cells of the guinea-pig ileum
64. Synthesis and hypotensive activity of N-alkyl-N″-cyano-N′-pyridylguanidines
65. 86Rb efflux and spontaneous activity in guinea pig portal vein
66. Cardiovascular effects of a new coronary vasodilator N-(2-hydroxyethyl)nicotinamide nitrate (SG-75): comparison with nitroglycerin and diltiazem
67. Vasodilating effects on nicorandil and nitroglycerin in anaesthetized open-chest dogs
68. + channels in isolated pacemaker cells from guinea-pig heart
69. Stimulation of coronary guanylate cyclase by nicorandil (SG-75) as a mechanism of its vasodilating action
70. + conductance in cardiac muscle
71. Recovery of contractile function in post-ischemic reperfused myocardium of conscious dogs: influence of nicorandil, a new antianginal agent
72. The hypotensive mechanisms of the antianginal drug, N-(2-hydroxyethyl)nicotinamide nitrate (SG-75) in Beagle dogs
73. Characterization of calcium-activated potassium channels in single smooth muscle cells using the patch clamp technique
74. Comparison of rubidium-86 and potassium-42 fluxes in rat aorta
75. An investigation into the mechanism of action of pinacidil in rat blood vessels
76. Comparison of the effects of BRL 34915 and of acetylcholine-liberated EDRF on rat isolated aorta
77. +-channel-blocking agents on responses to BRL 34915 and pinacidil in the isolated rat portal vein
78. The potassium channel opening action of pinacidil; studies using biochemical, ion flux and microelectrode techniques
79. The Relation Between Vascular Relaxant and Cardiac Electrophysiological Effects of Pinacidil
80. The sulphonylurea receptor may be an ATP-sensitive potassium channel
81. 2+ uptake by highly purified sarcoleumal vesicles of vascular smooth muscle
82. Actions of nicorandil on vascular smooth muscles
83. Endothelium dependent effects of acetylcholine on membrane potential, potassium flux and cyclic GMP concentrations in rat aorta: a comparison with sodium nitroprusside and the potassium channel opener, BRL 34915
84. + channel in mouse pancreatic β-cells
85. Effects of SG-75 (2-nicotinamido ethyl nitrate) on coronary circulation
86. Decreasing potassium conductance—a possible mechanism of phasic coronary vasospasm
87. Potassium channel activators: hypotensive activity and tolerance: a study with BRL 34915
88. Potassium channel activators lower blood pressure—an initial study of BRL 34915 in hypertensive patients
89. Effect of apamin on responses to BRL 34915, nicorandil and other relaxants in the guinea-pig taenia caeci
90. 86Rb efflux in rat blood vessels
91. The Mode of Action of Pinacidil and Its Analogs P1060 and P1368
92. + channel blockers
93. In vivo and in vitro studies of BRL 34915 and glibenclamide in the rat
94. The different mechanisms of action of nicorandil and adenosine triphosphate on potassium channels of circular smooth muscle of the guinea-pig small intestine
95. Effect of 2-nicotinamidethyl nitrate (SG-75) on the membrane potential of left atrial muscle fibres of the dog
96. Effect of 2-nicotinamidethyl nitrate (SG-75) on membrane potentials of canine Purkinje fibers.