The Single-Chain Form of Tissue-Type Plasminogen Activator Has Catalytic Actvity: Studies with a Mutant Enzyme That Lacks the Cleavage Site

Biochemistry

Volumn 28, Issue 2, 1989, Pages 635-643

  Boose, Jeri Ann ^a   Kuismanen, Esa ^b   Gerard, Robert ^c   Sambrook, Joe ^c   Gething, Mary Jane ^a,c  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF HELSINKI   (Finland)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; RECOMBINANT PROTEIN; SERINE PROTEINASE INHIBITOR; TISSUE PLASMINOGEN ACTIVATOR;

ANIMAL CELL; CELL CULTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; GENETIC ENGINEERING; HAMSTER; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; BASE SEQUENCE; BINDING SITES; COMPARATIVE STUDY; DNA, RECOMBINANT; HUMAN; INDICATORS AND REAGENTS; KINETICS; MACROMOLECULAR SYSTEMS; MOLECULAR SEQUENCE DATA; MUTATION; SUPPORT, NON-U.S. GOV'T; TISSUE PLASMINOGEN ACTIVATOR;

EID: 0024532410     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi00428a033     Document Type: Article

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