메뉴 건너뛰기




Volumn 49, Issue 1, 1989, Pages 68-71

Anticancer Drugs as Inhibitors of Two Polymorphic Cytochrome P450 Enzymes, Debrisoquin and Mephenytoin Hydroxylase, in Human Liver Microsomes

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; CYTOCHROME P450; DEBRISOQUINE; ENZYME INHIBITOR; ETOPOSIDE; IFOSFAMIDE; MEPHENYTOIN; MITOFLAXONE; OXYGENASE; TENIPOSIDE; VINBLASTINE; VINCRISTINE;

EID: 0024529709     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (41)

References (34)
  • 1
    • 0023750435 scopus 로고
    • Clinical pharmacodynamics of anticancer drugs: a basis for extending the concept of dose-intensity
    • Evans, W. E. Clinical pharmacodynamics of anticancer drugs: a basis for extending the concept of dose-intensity. Blut, 56:241-248, 1988.
    • (1988) Blut , vol.56 , pp. 241-248
    • Evans, W.E.1
  • 2
    • 0023607601 scopus 로고
    • Clinical pharmacodynamics of continuous infusion teniposide: systemic exposure as a determinant of response in a Phase I trial
    • Rodman, J. H., Abromowitch, M., Sinkule, J. A., Rivera, G. K., and Evans, W. E. Clinical pharmacodynamics of continuous infusion teniposide: systemic exposure as a determinant of response in a Phase I trial. J. Clin. Oncol., 5:1007-1014, 1987.
    • (1987) J. Clin. Oncol. , vol.5 , pp. 1007-1014
    • Rodman, J.H.1    Abromowitch, M.2    Sinkule, J.A.3    Rivera, G.K.4    Evans, W.E.5
  • 3
    • 0023595293 scopus 로고
    • Blood levels of cancer chemotherapeutic agents and clinical outcome
    • Bertino, J. R. Blood levels of cancer chemotherapeutic agents and clinical outcome. J. Clin. Oncol., 5:996, 1987.
    • (1987) J. Clin. Oncol. , vol.5
    • Bertino, J.R.1
  • 5
    • 0023618618 scopus 로고
    • Therapeutic drug monitoring in oncology, problems and potential in antineoplastic therapy
    • Erlichman, C., et al. Therapeutic drug monitoring in oncology, problems and potential in antineoplastic therapy. Clin. Pharmacokin., 13:205-227, 1987.
    • (1987) Clin. Pharmacokin , vol.13 , pp. 205-227
    • Erlichman, C.1
  • 9
    • 0021684926 scopus 로고
    • Mephenytoin hydroxylation deficiency in Caucasians: frequency of a new oxidative drug metabolism polymorphism
    • Wedlund, P. J., Aslanian, W. S., McAllister, C. G., Wilkinson, G. R., and Branch, R. A. Mephenytoin hydroxylation deficiency in Caucasians: frequency of a new oxidative drug metabolism polymorphism. Clin. Pharmacol. Ther., 36:773-780, 1984.
    • (1984) Clin. Pharmacol. Ther. , vol.36 , pp. 773-780
    • Wedlund, P.J.1    Aslanian, W.S.2    McAllister, C.G.3    Wilkinson, G.R.4    Branch, R.A.5
  • 10
    • 0022454027 scopus 로고
    • The genetic defect of mephenytoin hydroxylation
    • Kalow, W. The genetic defect of mephenytoin hydroxylation. Xenobiotica, 16:379-390, 1986.
    • (1986) Xenobiotica , vol.16 , pp. 379-390
    • Kalow, W.1
  • 11
    • 0010934844 scopus 로고
    • Family study of a genetically determined deficiency of mephenytoin hydroxylation in man
    • Kupfer, A., Desmond, P., Schenker, S., and Branch, R. Family study of a genetically determined deficiency of mephenytoin hydroxylation in man. Pharmacologist, 21:173, 1979.
    • (1979) Pharmacologist , vol.21 , pp. 173
    • Kupfer, A.1    Desmond, P.2    Schenker, S.3    Branch, R.4
  • 13
    • 0023684586 scopus 로고
    • Absence of hepatic cytochrome P 450 bufl causes genetically deficient debrisoquine oxidation in man
    • Zanger, U. M., Vilbois, F., Hardwick, J. P., and Meyer, U. A. Absence of hepatic cytochrome P 450 bufl causes genetically deficient debrisoquine oxidation in man. Biochemistry, 27:5447-5454, 1988.
    • (1988) Biochemistry , vol.27 , pp. 5447-5454
    • Zanger, U.M.1    Vilbois, F.2    Hardwick, J.P.3    Meyer, U.A.4
  • 14
    • 0022344457 scopus 로고
    • Mephenytoin hydroxylation polymorphism: characterization of the enzymatic deficiency in liver microsomes of poor metabolizers phenotyped in vivo
    • Meier, U. T., Dayer, P., Male, P. J., Kronbach, T., and Meyer, U. A. Mephenytoin hydroxylation polymorphism: characterization of the enzymatic deficiency in liver microsomes of poor metabolizers phenotyped in vivo. Clin. Pharmacol. Ther., 38:488-494, 1985.
    • (1985) Clin. Pharmacol. Ther. , vol.38 , pp. 488-494
    • Meier, U.T.1    Dayer, P.2    Male, P.J.3    Kronbach, T.4    Meyer, U.A.5
  • 15
    • 0022212549 scopus 로고
    • Stereoselective mephobarbital hydroxylation cosegregates with mephenytoin hydroxylation
    • Kupfer, A., and Branch, R. A. Stereoselective mephobarbital hydroxylation cosegregates with mephenytoin hydroxylation. CUn. Pharmacol. Ther., 38: 414-418, 1985.
    • (1985) CUn. Pharmacol. Ther. , vol.38 , pp. 414-418
    • Kupfer, A.1    Branch, R.A.2
  • 16
    • 0023951396 scopus 로고
    • Roles of cytochrome P 450 enzymes in chemical carcinogenesis and cancer chemotherapy
    • Guengerich, F. P. Roles of cytochrome P 450 enzymes in chemical carcinogenesis and cancer chemotherapy. Cancer Res., 48: 2946-2954, 1988.
    • (1988) Cancer Res. , vol.48 , pp. 2946-2954
    • Guengerich, F.P.1
  • 17
    • 0021130765 scopus 로고
    • Metabolic oxidation phenotypes as markers for susceptibility to lung cancer
    • Lond.
    • Ayesh, R., Idle, J. R., Ritchie, J. C., Crothers, M. J., and Hetzel, M. R. Metabolic oxidation phenotypes as markers for susceptibility to lung cancer. Nature (Lond.), 312:169-170, 1984.
    • (1984) Nature , vol.312 , pp. 169-170
    • Ayesh, R.1    Idle, J.R.2    Ritchie, J.C.3    Crothers, M.J.4    Hetzel, M.R.5
  • 18
    • 0019380168 scopus 로고
    • Some observations on the oxidation phenotype status of Nigerian patients presenting with cancer
    • Idle, J. R., Mahgoub, A., Sloan, T. P., Smith, R. L., Mbanefo, C. O., and Bababunmi, E. A. Some observations on the oxidation phenotype status of Nigerian patients presenting with cancer. Cancer Lett., 11:331-338, 1981.
    • (1981) Cancer Lett. , vol.11 , pp. 331-338
    • Idle, J.R.1    Mahgoub, A.2    Sloan, T.P.3    Smith, R.L.4    Mbanefo, C.O.5    Bababunmi, E.A.6
  • 19
    • 0023193252 scopus 로고
    • Genetic predisposition to bladder cancer: ability to hydroxylate debrisoquine and mephenytoin as risk factors
    • et al.
    • Kaisary, A., Smith, P., Jaczq, E., et al. Genetic predisposition to bladder cancer: ability to hydroxylate debrisoquine and mephenytoin as risk factors. Cancer Res., 47:5488-5493, 1987.
    • (1987) Cancer Res. , vol.47 , pp. 5488-5493
    • Kaisary, A.1    Smith, P.2    Jaczq, E.3
  • 20
    • 0020635141 scopus 로고
    • Hepatic monooxygenase activities in subjects with a genetic defect in drug oxidation
    • Meier, P. J., Mueller, H. K., Dick, B., and Meyer, U. A. Hepatic monooxygenase activities in subjects with a genetic defect in drug oxidation. Gastroenterology, 85:682-692, 1983.
    • (1983) Gastroenterology , vol.85 , pp. 682-692
    • Meier, P.J.1    Mueller, H.K.2    Dick, B.3    Meyer, U.A.4
  • 21
    • 0023258883 scopus 로고
    • High performance liquid chromatographic assays for bufuralol 1 '-hydroxylase, debrisoquine 4'-hydroxylase, and dextromethorphan β-demethylase in mi-crosomes and purified cytochrome P-450 isozymes of human liver
    • Kronbach, T., Mathys, D., Gut, J., Catin, T., and Meyer, U. A. High performance liquid chromatographic assays for bufuralol 1 '-hydroxylase, debrisoquine 4'-hydroxylase, and dextromethorphan β-demethylase in mi-crosomes and purified cytochrome P-450 isozymes of human liver. Anal. Biochem., 162:24-32, 1987.
    • (1987) Anal. Biochem. , vol.162 , pp. 24-32
    • Kronbach, T.1    Mathys, D.2    Gut, J.3    Catin, T.4    Meyer, U.A.5
  • 22
    • 0023754383 scopus 로고
    • Xenobiotic and endobiotic inhibitors of cytochrome P 450dbl function, the target of the debrisoquine/sparteine type polymorphism
    • Fonne-Pfister, R., and Meyer, U. A. Xenobiotic and endobiotic inhibitors of cytochrome P 450dbl function, the target of the debrisoquine/sparteine type polymorphism. Biochem. Pharmacol., 37: 3829-3836, 1988.
    • (1988) Biochem. Pharmacol. , vol.37 , pp. 3829-3836
    • Fonne-Pfister, R.1    Meyer, U.A.2
  • 23
    • 0022330348 scopus 로고
    • Assay of mephenytoin metabolism in human microsomes by high performance liquid chromatography
    • Meier, U. T., Kronbach, T., and Meyer, U. A. Assay of mephenytoin metabolism in human microsomes by high performance liquid chromatography. Anal. Biochem., 151:286-291, 1985.
    • (1985) Anal. Biochem. , vol.151 , pp. 286-291
    • Meier, U.T.1    Kronbach, T.2    Meyer, U.A.3
  • 24
    • 0021345446 scopus 로고
    • Competitive inhibition of sparteine oxidation in human liver by β-adrenoceptor antagonists and other cardiovascular drugs
    • Otton, S. V., Inaba, T., and Kalow, W. Competitive inhibition of sparteine oxidation in human liver by β-adrenoceptor antagonists and other cardiovascular drugs. Life Sci., 34:73-80, 1984.
    • (1984) Life Sci. , vol.34 , pp. 73-80
    • Otton, S.V.1    Inaba, T.2    Kalow, W.3
  • 25
    • 0022390883 scopus 로고
    • In vitro inhibition studies of two isozymes of human liver cyctochrome P-450, mephenytoin p-hydroxylase and sparteine monooxygenase
    • Inaba, T., Jurima, M., Mahon, W. A., and Kalow, W. In vitro inhibition studies of two isozymes of human liver cyctochrome P-450, mephenytoin p-hydroxylase and sparteine monooxygenase. Drug Metab. Dispos., 13:443-448, 1985.
    • (1985) Drug Metab. Dispos. , vol.13 , pp. 443-448
    • Inaba, T.1    Jurima, M.2    Mahon, W.A.3    Kalow, W.4
  • 26
    • 0023136337 scopus 로고
    • Characterization and inhibition of mephenytoin 4-hydroxylase activity in human liver microsomes
    • Hall, S. D., Guengerich, F. P., Branch, R. A., and Wilkinson, G. R. Characterization and inhibition of mephenytoin 4-hydroxylase activity in human liver microsomes. J. Pharmacol. Exp. Ther., 240:216-222, 1987.
    • (1987) J. Pharmacol. Exp. Ther. , vol.240 , pp. 216-222
    • Hall, S.D.1    Guengerich, F.P.2    Branch, R.A.3    Wilkinson, G.R.4
  • 28
    • 0022467917 scopus 로고
    • Oxidation of quinidine by human liver cytochrome P-450
    • Guengerich, F. P., Muller-Enoch, D., and Blair, I. A. Oxidation of quinidine by human liver cytochrome P-450. Mol. Pharmacol., 30:287-295, 1987.
    • (1987) Mol. Pharmacol. , vol.30 , pp. 287-295
    • Guengerich, F.P.1    Muller-Enoch, D.2    Blair, I.A.3
  • 29
    • 0022456656 scopus 로고
    • Pharmacokinetics and metabolism of quinidine in extensive and poor metabolisers of sparteine
    • Mikus, G., Ha, H. R., Vozeh, S., et al. Pharmacokinetics and metabolism of quinidine in extensive and poor metabolisers of sparteine. Eur. J. Clin. Pharmacol., 31:69-72, 1986.
    • (1986) Eur. J. Clin. Pharmacol , vol.31 , pp. 69-72
    • Mikus, G.1    Ha, H.R.2    Vozeh, S.3
  • 30
    • 0023235581 scopus 로고
    • The clinical pharmacology of etoposide and teniposide
    • Clark, P. I., and Slevin, M. L. The clinical pharmacology of etoposide and teniposide. Clin. Pharmacoldn., 12:223-252, 1987.
    • (1987) Clin. Pharmacoldn. , vol.12 , pp. 223-252
    • Clark, P.I.1    Slevin, M.L.2
  • 31
    • 0023260691 scopus 로고
    • Cytochrome P 450-mediated 0-demethylation: a route in the metabolic activation of etoposide
    • et al.
    • Van Maanen, J. M. S., De Vries, J., Pappie, D., et al. Cytochrome P 450-mediated 0-demethylation: a route in the metabolic activation of etoposide. Cancer Res., 47:4658-4662, 1987.
    • (1987) Cancer Res. , vol.47 , pp. 4658-4662
    • Van Maanen, J.M.S.1    De Vries, J.2    Pappie, D.3
  • 32
    • 0022257532 scopus 로고
    • Microsomal interactions and inhibition of lipid peroxidation by etoposide: implications for mode of action
    • Sinha, B. K., Trush, M. A., and Kalyanaraman, B. Microsomal interactions and inhibition of lipid peroxidation by etoposide: implications for mode of action. Biochem. Pharmacol., 34:2036-2040, 1985.
    • (1985) Biochem. Pharmacol. , vol.34 , pp. 2036-2040
    • Sinha, B.K.1    Trush, M.A.2    Kalyanaraman, B.3
  • 33
    • 0023608388 scopus 로고
    • Phase I and pharmacokinetic study of flavone acetic acid
    • Kerr, D. J., Kaye, S. B., Cassidy, J., et al. Phase I and pharmacokinetic study of flavone acetic acid. Cancer Res., 47:6776-6781, 1987.
    • (1987) Cancer Res , vol.47 , pp. 6776-6781
    • Kerr, D.J.1    Kaye, S.B.2    Cassidy, J.3
  • 34
    • 84969087676 scopus 로고
    • Cyclophosphamide and related phosphoramide mustards: current status and future prospects
    • Friedman, O. M., Myles, A., and Colvin, M. Cyclophosphamide and related phosphoramide mustards: current status and future prospects. Adv. Cancer Chemother., 1:143-204, 1986.
    • (1986) Adv. Cancer Chemother. , vol.1 , pp. 143-204
    • Friedman, O.M.1    Myles, A.2    Colvin, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.