Increased P‐glycoprotein expression and multidrug‐resistant gene (mdr1) amplification are infrequently found in fresh acute leukemia cells. Sequential analysis of 15 cases at initial presentation and relapsed stage

Cancer

Volumn 63, Issue 8, 1989, Pages 1534-1538

  Ito, Yoshinori ^a   Tanimoto, Mitsune ^a   Kumazawa, Takao ^a   Okumura, Masao ^a   Morishima, Yasuo ^a   Ohno, Ryuzo ^a   Saito, Hidehiko ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN P; MESSENGER RNA;

CYTOCHEMISTRY; DRUG RESISTANCE; GENE AMPLIFICATION; GENETIC ENGINEERING; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL;

ADULT; ANTIBODIES, MONOCLONAL; BLOOD PROTEINS; BLOTTING, NORTHERN; BLOTTING, SOUTHERN; DNA, NEOPLASM; DRUG RESISTANCE; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE AMPLIFICATION; HUMAN; LEUKEMIA; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGE; P-GLYCOPROTEIN; RECURRENCE; RNA, MESSENGER; RNA, NEOPLASM; SUPPORT, NON-U.S. GOV'T;

EID: 0024515070     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/1097-0142(19890415)63:8<1534::AID-CNCR2820630813>3.0.CO;2-N     Document Type: Article

References (27)

1. Reduced permeability in CHO cells as a mechanism of resistance to colchicine
2. Active outward transport of daunomycin in resistant Ehrlich ascites tumor cells
3. Altered surface membrane gly‐coproteins in vinca alkaloid‐resistant human leukemic lymphoblasts
4. Reduced drug accumulation in multiply drug‐resistant human KB carcinoma cell lines
5. Detection of P‐glycoprotein in multidrug‐resistant cell lines by monoclonal antibodies
6. Functional role for the 170‐ to 180‐kDa glycoprotein specific to drug‐resistant tumor cells as revealed by monoclonal antibodies
7. Altered plasma membrane glycocon‐jugates of Chinese hamster cells with acquired resistance to actionomycin D, daunorubicin, and vincristine
8. Amplification of P‐glycoprotein genes in multidrug‐resistant mammalian cell lines
9. Co‐amplification of double minute chromosomes, multiple drug resistance and cell surface P‐gly‐coprotein in DNA‐mediated transformants of mouse cells
10. Human multidrug‐resistant cell lines: Increased mdrl expression can precede gene amplification
11. DNA‐mediated transfer and cloning of a human multidrug‐resistant gene of Adriamycin‐resistant myelogenous leukemia K562
12. Overexpression and amplification of five genes in a multidrug‐resistant Chinese hamster ovary cell line
13. Isolation of human mdr DNA sequences amplified in multidrug‐resistant KB carcinoma cells
14. Genetic and biochemical characterization of multidrug resistance
15. The mdrl gene, responsible for multidrug‐resistance, codes for P‐glycoprotein
16. Internal duplication and ho‐mology with bacterial transport proteins in the mdrl (P‐glycoprotein) gene from multidrug‐resistant human cells
17. Expression of a multidrug‐resistance gene in human tumors and tissues
18. Detection of P‐glycoprotein in ovarian cancer: A molecular marker associated with multidrug resistance
19. P‐glycoprotein in human sarcoma: Evidence for multidrug‐resistance
20. Intrinsic drug resistance in human kidney cancer is associated with expression of a human multidrug‐resistance gene
21. Gene deletions Correlate with the development of alloantibodies in von Willebrand Disease
22. Isolation and partial nu‐cleotide sequence of a cDNA clone for human histocompatibility antigen HLA‐B by use of an oligodeoxynucleotide primer
23. Molecular cloning
24. Detection of a multidrug resistant phenotype in acute non‐lymphoblastic leukemia
25. Detection of multidrug resistance markers, P‐glycoprotein and mdrl mRNA, in human leukemia cells
26. Expression of multidrug‐resistant gene in hepatocarcinogenesis and regenerating rat liver