Stepwise Mechanism of HIV Reverse Transcriptase: Primer Function of Phosphorothioate Oligodeoxynucleotide

Biochemistry

Volumn 28, Issue 3, 1989, Pages 1340-1346

  Majumdar, Chirabrata ^a   Stein, Cy A ^a   Cohen, Jack S ^a   Broder, Samuel ^a   Wilson, Samuel H ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OLIGODEOXYNUCLEOTIDE; PHOSPHOROTHIOIC ACID; RNA DIRECTED DNA POLYMERASE;

ENZYME INHIBITION; ENZYME MECHANISM; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; INHIBITION KINETICS; PRIORITY JOURNAL;

BINDING, COMPETITIVE; DNA REPLICATION; DNA-DIRECTED DNA POLYMERASE; HIV; KINETICS; MATHEMATICS; OLIGODEOXYRIBONUCLEOTIDES; REVERSE TRANSCRIPTASE INHIBITORS; RNA-DIRECTED DNA POLYMERASE; SUPPORT, U.S. GOV'T, NON-P.H.S.; TEMPLATES, GENETIC; THIONUCLEOTIDES;

EID: 0024505583     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi00429a060     Document Type: Article

References (31)

1. Abbotts, J., SenGupta, D.N., Zmudzka, B., Widen, S.G., Notario, V., & Wilson, S.H. (1988), Biochemistry 27, 901-909.
2. Albert, W., Grummt, F., Hubscher, U., & Wilson S.H. (1982) Nucleic Acids Res. 10, 935-946.
3. Cheng, Y.-C., Dutschman, G.E., Bastow, K.F., Sarngadharan, M.G., & Ting, R.Y.C. (1987) J. Biol. Chem. 262, 2189-2191.
4. Cleland, W.W. (1963a) Biochim. Biophys. Acta 67, 104-137.
5. Cleland, W.W. (1963b) Biochim. Biophys. Acta 67, 173-187.
6. Detera, D.S., & Wilson, S.H. (1982) J. Biol. Chem. 257, 9770-9780.
7. Fersht, A. (1985) Enzyme Structure and Mechanism, W. H. Freeman, New York.
8. Gilboa, E., Mitra, S.W., Goff, S, & Baltimore, D. (1979) Cell 18, 93-100.
9. Haseltine, W.A., Panet, A., Smoler, D., Baltimore, D., Peters, G., Harada, F., & Dahlberg, J.E. (1977) Biochemistry 16, 3625-3632.
10. Hawley, D.K., Johnson, A.D., & McClure, W.R. (1985) J. Biol. Chem. 260, 8618-8626.
11. Johnson, A.D., Pabo, C.O., & Sauer, R.T. (1980) Methods Enzymol. 65, 839-856.
12. Klig, L.S., & Yanofsky, C. (1988) J. Biol. Chem. 263, 243-246.
13. Knott, G.D., & Shrager, R.I. (1972) Proc. Siggraph. Corn-put. Med. Symph. 6, 138.
14. Kuchta, R.D., Mizrahi, V., Benkovic, P.A., Johnson, K.A., & Benkovic, S.J. (1987) Biochemistry 26, 8410-8417.
15. Levin, J.G., & Seidman, J.G. (1979) J. Virol. 29, 328-335.
16. Levin, J.G., & Seidman, J.G. (1981) J. Virol. 38, 403-408.
17. Majumdar, C., Abbotts, J., Broder, S., & Wilson, S.H. (1988) J. Biol. Chem. 263, 15657-15665.
18. Matsukura, M., Sinozuka, K., Zon, G., Mitsuya, H., Reitz, M., Cohen, J. S., & Broder, S. (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 7706-7710.
19. McClure, W.R., & Jovin, T.M. (1975) J. Biol. Chem. 250, 4073-4080.
20. Mulligan, M.E., Brosius, J., & McClure, W.R. (1985) J. Biol. Chem. 260, 3529-3538.
21. Panet, A., & Berliner, H. (1978) J. Virol. 26, 214-220.
22. Panet, A., Haseltine, W.A., Baltimore, D., Peters, G., Harada, F., & Dahlberg, J.E. (1975) Proc. Natl. Acad. Sci. U.S.A. 72, 2535-2539.
23. Peters, G., & Hu, J. (1980) J. Virol. 36, 692-700.
24. Pingoud, A., Boehme, D., Riesmer, D., Kownatski, R., & Maass, G. (1975) Eur. J. Biochem. 56, 617-622.
25. Sawyer, R.C, & Hanafusa, H. (1979) J. Virol. 29, 863-871.
26. Schrier, B.K., & Wilson, S.H. (1975) Methods Cell Biol. 13, 105-120.
27. Stec, W.J., Zon, G., Egan, W, & Stec, B. (1984) J. Am. Chem. Soc. 106, 6077-6079.
28. Stein, C.A., Subasinghe, C., Shinozuka, K., & Cohen, J.S. (1988) Nucleic Acids Res. 16, 3209-3221.
29. Winter, R.B., Berg, O.G., & von Hippel, P.H. (1981) Biochemistry 20, 6961-6977.
30. Yarchoan, R., & Broder, S. (1987) N. Engl. J. Med. 316, 557-564.
31. Yuras, M., & Berg, P. (1967) Mol. Biol. 28, 479-490.