The NMDA antagonist MK-801 causes marked locomotor stimulation in monoamine-depleted mice

Journal of Neural Transmission

Volumn 75, Issue 3, 1989, Pages 221-226

  Carlsson, Maria ^a   Carlsson, A ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

brain; dopamine; glutamate; MK 801; mouse; NMDA receptors

Indexed keywords

DIZOCILPINE; DOPAMINE; HALOPERIDOL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL EXPERIMENT; AROUSAL; CORPUS STRIATUM; INTRAPERITONEAL DRUG ADMINISTRATION; LOCOMOTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ALPHA-METHYLTYROSINE; ANIMAL; BIOGENIC MONOAMINES; DIBENZOCYCLOHEPTENES; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; HALOPERIDOL; MALE; METHYLTYROSINES; MICE; MOTOR ACTIVITY; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, NEUROTRANSMITTER; RESERPINE; SUPPORT, NON-U.S. GOV'T;

EID: 0024501249     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/BF01258633     Document Type: Article

References (13)

1. The current status of the dopamine hypothesis of schizophrenia
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3. Central sympathomimetic activity of (+)-5-methyl-10-11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine (MK-801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties
4. Restoration of shock-suppressed behavior by treatment with (+)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine (MK-801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties
5. Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil
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8. Zur biochemischen Theorie der Schizophrenie
9. Anticonvulsant and anti-epileptogenic actions of MK-801 in the kindling and electroshock models
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11. The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist