Successful Treatment with Foscarnet of an Acyclovir-Resistant Mucocutaneous Infection with Herpes Simplex Virus in a Patient with Acquired Immunodeficiency Syndrome

New England Journal of Medicine

Volumn 320, Issue 5, 1989, Pages 297-300

  Chatis, P A ^a   Miller, C H ^b   Schrager, L E ^b   Crumpacker, C S ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; FOSCARNET; ANTIVIRUS AGENT; DRUG DERIVATIVE; ORGANOPHOSPHORUS COMPOUND; PHOSPHONOACETIC ACID;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; CASE REPORT; DRUG RESISTANCE; FEMALE; HERPES SIMPLEX VIRUS 2; HERPES VIRUS INFECTION; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; PRIORITY JOURNAL; ANTIBIOTIC RESISTANCE; ARTICLE; DRUG EFFECT; GENITAL HERPES; HERPES SIMPLEX; HERPES SIMPLEX VIRUS; ISOLATION AND PURIFICATION; SKIN INFECTION;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ACYCLOVIR; ADULT; ANTIVIRAL AGENTS; CASE REPORT; DRUG RESISTANCE, MICROBIAL; FEMALE; FOSCARNET; HERPES GENITALIS; HERPES SIMPLEX; HUMAN; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHONOACETIC ACID; SIMPLEXVIRUS; SKIN DISEASES, INFECTIOUS;

EID: 0024476921     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM198902023200507     Document Type: Article

References (17)

1. Crumpacker CS. Resistance of herpes viruses to nucleoside analogues—mechanisms and clinical importance. In: Declercq E, ed. Clinical use of antiviral drugs. The Hague: Martinus Nijhoff, 1988:207–22.
2. Dorsky DI, Crumpacker CS. Drugs five years later: acyclovir. Ann Intern Med 1987; 107: 859–74.
3. Elion GB, Furman PA, Fyfe JA, deMiranda P, Beauchamp L, Schaeffer HJ. Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine. Proc Natl Acad Sci USA 1977; 74: 5716–20.
4. Furman PA, St Clair MH, Fyfe JA, Rideout JL, Keller PM, Elion GB. Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl) guanine and its triphosphate. J Virol 1979; 32: 72–7.
5. Burns WH, Saral R, Santos GW, et al. Isolation and characterisation of resistant herpes simplex virus after acyclovir therapy. Lancet 1982; 1: 421–3.
6. Crumpacker CS, Chartrand P, Subak-Sharpe JH, Wilkie NM. Resistance of herpes simplex virus to acycloguanosine — genetic and physical analysis. Virology 1980; 105: 171–84.
7. Crumpacker CS, Schnipper LE, Marlowe SI, Kowalsky PN, Hershey BJ, Levin MJ. Resistance to antiviral drugs of herpes simplex virus isolated from a patient treated with acyclovir. N Engl J Med 1982; 306: 343–6.
8. Norris SA, Kessler HA, Fife KH. Severe, progressive herpetic whitlow caused by an acyclovir-resistant virus in a patient with AIDS. J Infect Dis 1988; 157: 209–10.
9. Sibrack CD, Gutman LT, Wilfert CM, et al. Pathogenicity of acyclovir-resistant herpes simplex virus type 1 from an immunodeficient child. J Infect Dis 1982; 146: 673–82.
10. Whitley RJ, Levin M, Barton N. Infections caused by herpes simplex virus in the immunocompromised host: natural history and topical acyclovir therapy. J Infect Dis 1984; 150: 323–9.
11. Erlich KS, Mills J, Chatis P, et al. Acyclovir-resistant herpes simplex virus infections in patients with the acquired immunodeficiency syndrome. N Engl J Med 1989; 320: 293–6.
12. Jamieson AT, Gentry GA, Subak-Sharpe JH. Induction of both thymidine and deoxycytidine kinase activity by herpes viruses. J Gen Virol 1974; 24: 465–80.
13. Quinlan MP, Chen LB, Knipe DM. The intranuclear location of a herpes simplex virus DNA-binding protein is determined by the status of viral DNA replication. Cell 1984; 36: 857–68.
14. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680–5.
15. Lonsdale DM. A rapid technique for distinguishing herpes-simplex virus type 1 from type 2 by restriction-enzyme technology. Lancet 1979; 1: 849–52.
16. Kit S, Kit M, Qavi H, Trkula D, Otsuka H. Nucleotide sequence of the herpes simplex virus type 2 (HSV-2) thymidine kinase gene and predicted amino acid sequence of thymidine kinase polypeptide and its comparison with the HSV-1 thymidine kinase gene. Biochim Biophys Acta 1983; 741: 158–70.
17. Gill MJ, Denhollander C. DNA restriction enzyme analysis of digital and genital isolates of herpes simplex virus from three patients. J Infect Dis 1988; 158: 242.